Clinicoepidemiological and histopathological study of cutaneous amyloidosis with histopathological correlation

Kilaparty, Kavita; Maripati, Lavanya

doi:10.18203/2349-3933.ijam20162526

Cited by 3 publications

(7 citation statements)

References 9 publications

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“…In other studies, MA was determined more in younger ages such as 21-40, while LA was found more between the ages of 41-50. [18,24] In this study, it was determined that both LA and MA appeared at a later age, as in another study made in our country. [31] PIH can be seen at every age.…”

Section: Discussionsupporting

confidence: 58%

“…Studies have shown that the duration of PCA disease ranges from 3 months to 40 years. [19,21,23,24,29] In our study, this period was found to be between 1 year and 20 years, the average duration was 10.6 years in macular type and 11.2 years in lichenoid type. These changes may be due to the patients being followed up in different places, not being diagnosed or missed.…”

Section: Discussionmentioning

confidence: 44%

“…PCA is generally seen equally in young adults and in both genders, while male superiority was found 63-86% in some studies, [13,34,35] but some studies reported female superiority. [13,17,18,23,24,28,30,31] We also saw the M/ F ratio of 1: 3 and more in female. The reason why PCA is seen more in female may be due to the high number of applications due to hormonal or cosmetic concerns.…”

Section: Discussionmentioning

confidence: 61%

“…The researchers found the average age of cases with amyloidosis between 28-48.35. [13,17,19,[23][24][25][26][27][28][29][30] In this study, the mean age of the patients with PCA was 49.3 years.…”

Section: Discussionmentioning

confidence: 72%

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Clinical and Demographic Characteristics of The Patients with Diffuse Hyperpigmentation

Akbaş¹

2020

South Clin Ist Euras

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Objective: Hyperpigmentation is a condition characterized by the accumulation of pigment in the epidermis and dermis. Many dermatological diseases, such as primary cutaneous amyloidosis (PCA), postinflammatory hyperpigmentation (PIH), erythema discromicum perstans (EDP), notalgia paresthetica (NP), drug reaction (DR), may lead to acquired hyperpigmentation on the skin. The aim of this study is to investigate etiologic factors, clinical and demographic features, laboratory findings and treatment options in patients with generalized hyperpigmentation.Methods: Forty four patients who presented to our outpatient clinic with complaints of hyperpigmentation were evaluated retrospectively. Patients were examined in terms of age, duration and localization of lesions, accompanying symptoms or diseases, laboratory findings and treatment options.Results: When pigmentation-causing diseases are listed; PCA was detected in 50% of the cases. Of these, 72.7% (n=16) were macular amyloidosis, 22.7% (n=5) were lichen amyloidosis, and 4.6% (n=1) were biphasic amyloidosis. Others were 29.5% (n=13) PIH, 13.6% (n=6) EDP, 4.6% (n=2) NP, 2.3% (n=1) DR. The ages of the patients were generally between 20-69 years. The average age was mean 47.8 years (48.8 for females and 45.0 for males). The duration of pigmentation ranged from 3 months to 20 years (mean 6.8 years). 75% (n=33) of the patients had itching. About half of the lesions were located on the back. Half of the patients had a concomitant disease. As treatment options, 9 patients were treated with phototherapy, 9 with isotretinoin, 12 with depigmentation, and one with pregabalin and topical steroids. Conclusion:Knowing the conditions that cause hyperpigmentation facilitates the diagnosis of the disease. In this study, PCA was detected in half of the patients with clinically considered hyperpigmentation. Therefore, the diagnosis of PCA should be considered first in patients with pruritic and diffuse pigmentation.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 72%

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Clinical and Demographic Characteristics of The Patients with Diffuse Hyperpigmentation

Akbaş¹

2020

South Clin Ist Euras

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“…A recent study from India showed 32% were asymptomatic and 68% were symptomatic which was similar to the present study. [15]…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological study of primary cutaneous amyloidosis in a tertiary care center of Eastern India reveals insignificant association with friction, scrubbing, and photo-exposure: How valid is the “keratinocyte hypothesis”?

Biswas

Pal

et al. 2019

Indian J Dermatol

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Introduction:Primary cutaneous amyloidosis (PCA) can be classified into four principal categories: macular amyloidosis, lichen amyloidosis, biphasic, and nodular amyloidosis. Some unusual variants such as widespread diffuse hyperpigmentation without papules, poikiloderma like involvement, lesions following Blaschko's line, etc., have also been reported. However, not much data are available regarding the demography, epidemiology, clinical patterns, and distribution and histopathological findings, especially from the eastern part of India.Aims:We conducted a cross-sectional, institution-based study to evaluate clinicopathological pattern and factors of PCA in eastern India.Materials and Methods:We recorded clinical and histopathological findings of 100 consecutive patients of PCA presenting to a tertiary care institution of Kolkata in eastern India.Results:We found female patients of PCA outnumber male (M:F =1:1.9) with majority of patients being young adults (56%) between 20 and 40 years of age. More than half (54%) of the patients were pruritic. The severity of pruritus is significantly more associated with lichenoid and biphasic variants over macular amyloidosis. Positive family history was recorded in 17% of cases. Macular variant was the most common variant constituting 48% of the total PCA. We also found that the association with history of friction and scrubbing and photo-exposure were statistically insignificant. However, duration of the disease has statistically significant association with the disease morphology. Congo red stain showed these deposits as reddish orange substance in 28 patients out of 64 patients’ samples on which Congo red could be performed.Conclusion:Our study revealed that many concepts of pathogenesis of PCA including friction and photoexposure might have lesser importance. However, morphological types were significantly associated with the duration of the disease and symptom severity.

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Primary cutaneous amyloidosis: A review of the available studies and gaps in data

Aung¹,

Noakes²,

Murrell

et al. 2023

Aust J Dermatology

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Clinicoepidemiological and histopathological study of cutaneous amyloidosis with histopathological correlation

Cited by 3 publications

References 9 publications

Clinical and Demographic Characteristics of The Patients with Diffuse Hyperpigmentation

Clinical and Demographic Characteristics of The Patients with Diffuse Hyperpigmentation

Clinicopathological study of primary cutaneous amyloidosis in a tertiary care center of Eastern India reveals insignificant association with friction, scrubbing, and photo-exposure: How valid is the “keratinocyte hypothesis”?

Primary cutaneous amyloidosis: A review of the available studies and gaps in data

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