Primary cutaneous amyloidosis: A review of the available studies and gaps in data

Treatment of primary cutaneous lichenoid amyloidosis with abrocitinib: A pilot study in two cases

“…Lichen amyloidosis is a common variant of PCLA in which pruritus is intense or a predominant symptom. 1,4 In our reports, recalcitrant chronic itch in two patients that failed other therapies markedly improved when treated with abrocinitib.…”

“…PG-like presentations of cutaneous sporotrichosis have been described. [1][2][3][4][5] Our case highlights the diagnostic challenge that cutaneous sporotrichosis poses due to the initial presentation of pustules which rapidly ulcerated into cribriform ulcers and its similarity in presentation to PG. Furthermore, this patient had a hematologic malignancy, a population at increased risk for developing PG.…”

“…Dear Editor, Primary cutaneous lichenoid amyloidosis (PCLA) is featured by the deposition amyloid, originated from keratinocytes within the papillary dermis and lacking systemic involvement. 1 Various therapies including topical and intralesional corticosteroids, systemic retinoids, psoralen 1 ultraviolet A and UVB phototherapy, cyclosporine, cryosurgery, dupilumab, Janus kinase (JAK) inhibitors, and surgical interventions and lasers have been used for treating PCLA. 1,2 Current treatments are based on case reports and offlabel trails, and standardized treatment has not been established.…”

Pruritic papules of the leg

“…The differential diagnoses for pruritic papular eruption involving the legs include pretibial pruritic papular dermatitis (PPPD), lichen amyloidosis, prurigo nodularis, hypertrophic lichen planus, lichen simplex chronicus and pretibial myxoedema. 1,2 Necrobiosis lipoidica can also be considered in the context of diabetes. The clinical and histopathological features of these dermatoses are outlined in Table 1.…”