A case of lichen amyloidosis treated with pulsed dye laser

Sawamura, Daisuke; Sato‐Matsumura, Kazuko C.; Shibaki, Akihiko; Akiyama, Masashi; Kikuchi, Takanori; Shimizu, Hiroshi

doi:10.1111/j.1468-3083.2005.01038.x

Cited by 18 publications

(11 citation statements)

References 11 publications

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“…Potent topical corticosteroids (under occlusion), topical calcineurin inhibitors, topical dimethyl sulfoxide (DMSO), intralesional corticosteroids, PUVA and UVB phototherapy, systemic retinoids, low-dose cyclophosphamide, cyclosporine have been used for medical management of LA. [6] The physical modalities of treatment such as electrodessication,[1] dermabrasion,[23] pulsed dye laser[4] and frequency- doubled Q-switched Nd: YAG laser[5] where epidermis and part of the papillary dermis along with some of the amyloid was removed permitting re-epithelialization to occur from adnexal structures have been reported to be effective in the treatment of LA.…”

Section: Discussionmentioning

confidence: 99%

“…It usually presents as persistent, pruritic, hyperkeratotic papules that may coalesce to form gray-brown plaques, on the shins or other extensor surfaces of the extremities. The condition is resistant to treatment and various treatment modalities such as electrodessication,[1] dermabrasion,[23] pulsed dye laser[4] and frequency-doubled Q-switched Nd: YAG laser[5] have been previously tried with variable therapeutic response. Here we are reporting a case of LA which showed good response for Fractional ablative 2,940 nm Erbium: YAG Laser treatment.…”

Section: Introductionmentioning

confidence: 99%

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Lichen amyloidosis: Novel treatment with fractional ablative 2,940 nm Erbium: YAG laser treatment

Anitha¹,

Mysore²

2012

J Cutan Aesthet Surg

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Lichen amyloidosis (LA) is a type of primary localized cutaneous amyloidosis clinically characterized by persistent pruritic, hyperkeratotic papules commonly distributed on the shins and histopathologically characterized by amyloid deposits in the papillary dermis. The condition is difficult to treat though various treatment modalities have been tried. We report a case of LA treated successfully with Fractional ablative 2,940 nm Erbium: YAG Laser treatment. To the best of our knowledge, this is the first documented report of the successful use of fractional ablative laser in the treatment of LA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lichen amyloidosis: Novel treatment with fractional ablative 2,940 nm Erbium: YAG laser treatment

Anitha¹,

Mysore²

2012

J Cutan Aesthet Surg

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“…Other systemic therapies include ciclosporin, 38 pulsed dexamethasone–cyclophosphamide 69 or aciclovir and interferon‐α 70 . Physical treatments include dermabrasion, 71 Nd:YAG laser 72 and pulsed dye laser 73 . Hydrocolloid dressings to the skin have also been advocated as being helpful in controlling pruritic symptoms 74 …”

Section: Management Of Primary Localized Cutaneous Amyloidosis: New Tmentioning

confidence: 99%

New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis

Tanaka

Arita

Lai-Cheong

et al. 2009

British Journal of Dermatology

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Macular and lichen amyloidosis are common variants of primary localized cutaneous amyloidosis (PLCA) in which clinical features of pruritus and skin scratching are associated with histological findings of deposits of amyloid staining on keratinous debris in the papillary dermis. Most cases are sporadic, but an autosomal dominant family history may be present in up to 10% of cases, consistent with a genetic predisposition in some individuals. Familial PLCA has been mapped to a locus on 5p13.1-q11.2 and in 2008 pathogenic heterozygous missense mutations were identified in the OSMR gene, which encodes oncostatin M receptor beta (OSMRbeta), an interleukin (IL)-6 family cytokine receptor. OSMRbeta is expressed in various cell types, including keratinocytes, cutaneous nerves and nociceptive neurones in dorsal root ganglia; its ligands are oncostatin M and IL-31. All pathogenic mutations are clustered in the fibronectin-III repeat domains of the extracellular part of OSMRbeta, sites that are critical for receptor dimerization (with either gp130 or IL-31RA), and lead to defective signalling through Janus kinase-signal transducers and activators of transcription, extracellular signal-regulated protein kinase 1/2 and phosphoinositide 3 kinase/Akt pathways. Elucidating the molecular pathology of familial PLCA provides new insight into mechanisms of pruritus in human skin, findings that may have relevance to developing novel treatments for skin itching. This review provides a clinicopathological and molecular update on familial PLCA.

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“…There are reports which have shown the benefits of using oral retinoids , topical calcineurin inhibitors, topical 50–100% dimethyl sulfoxide , cryosurgery , and narrowband UVB . In addition, physical treatments such as scalpel scraping , dermabrasion , elctrodessication , and lasers including the CO 2 laser , pulsed dye laser , Q‐switched Nd:YAG laser , and fractional ablative Nd:YAG laser have all been reported and have shown some clinical improvement.…”

Section: Discussionmentioning

confidence: 99%

Fractional 1,550nm Ytterbium/Erbium fiber laser in the treatment of lichen amyloidosis: Clinical and histological study

2015

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A case of lichen amyloidosis treated with pulsed dye laser

Cited by 18 publications

References 11 publications

Lichen amyloidosis: Novel treatment with fractional ablative 2,940 nm Erbium: YAG laser treatment

Lichen amyloidosis: Novel treatment with fractional ablative 2,940 nm Erbium: YAG laser treatment

New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis

Fractional 1,550nm Ytterbium/Erbium fiber laser in the treatment of lichen amyloidosis: Clinical and histological study

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