LACK OF c-myc GENE AMPLIFICATION IN GENITAL TUMOURS WITH DIFFERENT HPV STATUS

Telomerase Expression in Normal Epithelium, Reactive Atypia, Squamous Dysplasia, and Squamous Cell Carcinoma of the Uterine Cervix

“…Some studies have reported a high frequency of rearrangement or amplification of the c-myc proto-oncogene in cervical carcinomas, 35 " 39 but this has not been confirmed in other studies. [40][41][42] Similarly, Riou et al 43 reported the allelic loss of c-Ha-ras locus in 36% of cases of cervical carcinoma; however, this observation has not been subsequently confirmed. 44 47,48 In the current study, we show that telomerase activity can be detected in a high proportion of cases of cervical dysplasia and squamous cell carcinoma but is detected less frequently in normal cervical mucosa.…”

Immortalization and Transformation of Human Cells by Human Papillomavirus

“…Increased expression of c-myc was observed in cell lines from cervical carcinomas, e.g., HeLa and C4-1 cells, by DORST et al (1987b) who proposed that HPV integration in the region of c-myc might result in cis-activation of the oncogene with progression to malignancy. Despite the attractiveness of this hypothesis, a study by IKENBERG et al (1987) found no amplification of c-myc in a study of 28 H PV -positive invasive genital tumors. Transformation to malignancy has been achieved by cooperation between activated ras and H PV -16 in primary rodent cells (MATLASHEWSKI et al 1987) and in human cells (DURST et al 1989).…”