Lack of Association Between the IL1B (−511 and +3954), IL1RN VNTR Polymorphisms and Tuberculosis Risk: A Meta-analysis

Huang, Qiu-Pin; Liao, Ning; Zhao, Hua; Chen, Minli; Xie, Zijian

doi:10.1007/s00408-015-9796-5

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…To show the importance of IL6 in TB, murine models with mycobacterial infections and models with a TB subunit vaccine indicated that IL6 was essential for the development of an optimal T-cell response [ 28 ]. IL6 mRNA and protein expression were significantly elevated in the serum of PTB patients [ 29 ]. MTB stimulates the secretion of IL6 which inhibits IFN-signaling, thus enabling MTB to evade eradication by a cellular immune response [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms ofIL1B, IL6,andTNFαin a Chinese Han Population with Pulmonary Tuberculosis

Wang

Zhang

et al. 2018

BioMed Research International

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Background The factors that predispose to pulmonary tuberculosis (PTB) are not fully understood. Previous studies have shown that cytokine gene polymorphisms were associated with PTB. Objectives In this study, we have investigated the relationship between ILB, IL6, and TNFα polymorphisms and a predisposition to Mycobacterium tuberculosis (MTB) infection and PTB. Methods A total of 209 cases of PTB, 201 subjects with latent TB infection (LTBI), and 204 healthy controls (HCS) were included in this study. Logistic regression analyses under allelic, homozygous, and heterozygous models were used to calculate P values, odds ratios (ORs), and 95% confidence intervals (CIs) for assessing the association between single nucleotide polymorphisms (SNPs) and disease risk, adjusting for sex and age. Genotyping was conducted using the improved multiplex ligase detection reaction (iMLDR) method. Results When comparing PTB patients with LTBI subjects, significant associations with disease development were observed for SNPs of IL6 and TNFα. When comparing LTBI subjects with HCS, IL1B polymorphisms were significantly associated with LIBI. Haplotype analyses suggested that the CGG haplotype of IL1B was associated with an increased risk of PTB (P = 0.039, OR = 1.34, 95% CI: 1.01–1.76), while the TTGCG haplotype of TNFα was a protective factor against PTB (P = 0.039, OR = 0.66, 95% CI: 0.44–0.98). Conclusion Our study demonstrated that IL1B variants were related to LTBI and IL6 and TNFα variants were associated with PTB.

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Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms ofIL1B, IL6,andTNFαin a Chinese Han Population with Pulmonary Tuberculosis

Wang

Zhang

et al. 2018

BioMed Research International

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Association Analysis of Interleukin-17 Gene Polymorphisms with the Risk Susceptibility to Tuberculosis

Zhao

Wen

2016

Lung

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Interleukin-17 A and F gene polymorphisms affect the risk of tuberculosis: An updated meta-analysis

Eskandari-Nasab

Moghadampour

Tahmasebi

et al. 2018

Indian Journal of Tuberculosis

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Lack of Association Between the IL1B (−511 and +3954), IL1RN VNTR Polymorphisms and Tuberculosis Risk: A Meta-analysis

Abstract: Our results indicate there is a lack of association between the IL1B (-511 and +3954), IL1RN VNTR polymorphisms and TB risk.

Cited by 4 publications

References 25 publications

Genetic Polymorphisms ofIL1B, IL6,andTNFαin a Chinese Han Population with Pulmonary Tuberculosis

Genetic Polymorphisms ofIL1B, IL6,andTNFαin a Chinese Han Population with Pulmonary Tuberculosis

Association Analysis of Interleukin-17 Gene Polymorphisms with the Risk Susceptibility to Tuberculosis

Interleukin-17 A and F gene polymorphisms affect the risk of tuberculosis: An updated meta-analysis

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