Interleukin-17 A and F gene polymorphisms affect the risk of tuberculosis: An updated meta-analysis

Eskandari-Nasab, Ebrahim; Moghadampour, Mehdi; Tahmasebi, Arezoo; Asadi-Saghandi, Abolghasem

doi:10.1016/j.ijtb.2017.08.027

Cited by 14 publications

(17 citation statements)

References 29 publications

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“…30 The heterogeneity of both LTBI prevalence and progression to active TB in geographic areas within the same country and/or region raises questions that go beyond the BCG effectiveness and demographic, socioeconomic, and epidemiological characteristics. The influence of feature of M. tuberculosis strains and human genetics would be other factors to consider [31][32][33][34] and may have contributed to the different scenario verified in the municipality where our study was carried out.…”

Section: Discussionmentioning

confidence: 99%

Low Prevalence of Latent Tuberculosis Infection among Contacts of Smear-Positive Adults in Brazil

Oliveira-Cortez

Froede

Melo

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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This follow-up cross-sectional study aimed to analyze the prevalence rate and risk factors related to latent tuberculosis infection (LTBI) and active tuberculosis (TB) in children aged < 15 years in contact with adults with smearpositive pulmonary TB (PTB) in a Brazilian municipality. Data were collected from interviews, clinical evaluations, chest X-rays, tuberculin skin tests, and interferon gamma release assays. The median time elapsed between diagnosis of the index case (IC) and inclusion in the study was 2.5 years (interquartile range [IQR] = 1.5-4.4) and 7.4 years (IQR = 3.8-9.7) when we reassessed the development (or not) of active TB. The median age at the time of exposure to the IC was 6.6 years (IQR = 3.3-9.4) and 14.1 years (IQR = 8.9-17.7) at the last follow-up. Of the 99 children and adolescents in contact with smear-positive PTB, 21.2% (95% CI = 14.0-29.9) were diagnosed with LTBI, and none developed active TB. There was no statistically significant difference between the LTBI and non-LTBI groups regarding demographic, socioeconomic, and epidemiological characteristics. Unlike national and international scenarios, we found a lower frequency of LTBI and no active TB among our studied patients. For better understanding of these findings, further studies might add, among other factors, host and Mycobacterium tuberculosis genetic features.

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Section: Discussionmentioning

confidence: 99%

Low Prevalence of Latent Tuberculosis Infection among Contacts of Smear-Positive Adults in Brazil

Oliveira-Cortez

Froede

Melo

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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“…Mice deficient in IL-17 had significantly decreased levels of IFNγ after BCG infection [87]. Regarding genetic studies, the hypermorphic A-Allele of a SNP of IL17A-197A conveyed protection in a cohort of active PTB [88], although a recent meta-analysis revealed significance only in Latin America [89]. In summary, Th17 cells seem to play an important role in initial mycobacterial infection, but its overall impact is not clear.…”

Section: Il-12-the Key Cytokine For a Th1/17 Responsementioning

confidence: 99%

RNA Sensing of Mycobacterium tuberculosis and Its Impact on TB Vaccination Strategies

Burkert

Schumann

2020

Vaccines

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Tuberculosis (TB) is still an important global threat and although the causing organism has been discovered long ago, effective prevention strategies are lacking. Mycobacterium tuberculosis (MTB) is a unique pathogen with a complex host interaction. Understanding the immune responses upon infection with MTB is crucial for the development of new vaccination strategies and therapeutic targets for TB. Recently, it has been proposed that sensing bacterial nucleic acid in antigen-presenting cells via intracellular pattern recognition receptors (PRRs) is a central mechanism for initiating an effective host immune response. Here, we summarize key findings of the impact of mycobacterial RNA sensing for innate and adaptive host immunity after MTB infection, with emphasis on endosomal toll-like receptors (TLRs) and cytosolic sensors such as NLRP3 and RLRs, modulating T-cell differentiation through IL-12, IL-21, and type I interferons. Ultimately, these immunological pathways may impact immune memory and TB vaccine efficacy. The novel findings described here may change our current understanding of the host response to MTB and potentially impact clinical research, as well as future vaccination design. In this review, the current state of the art is summarized, and an outlook is given on how progress can be made.

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“…< 0.10 from to 182 SNPs for the LIM breed. Inspection of Supplementary Data 8 reveals notable gene loci associated with enriched GWAS SNPs for the HOFR breed including the allograft inflammatory factor 1 gene (AIF1), which encodes a protein that promotes macrophage activation and proinflammatory activity (Liu et al 2007); the ciliogenesis associated kinase 1 gene (CILK1 aka ICK); IL17A and IL7F, which encode proinflammatory cytokines and contain polymorphisms in the human orthologs that have been associated with lower human TB disease incidence (Wang et al 2016;Eskandari-Nasab et al 2018); the integrin subunit beta 3 gene (ITGB3), which encodes a protein that has been shown to regulate matrix metalloproteinase secretion in pulmonary human TB (Brilha et al 2017); the neuraminidase 1 gene (NEU1), which encodes a protein that regulates phagocytosis in macrophages (Seyrantepe et al 2010); and the TNF gene that encodes TNF (aka TNF-α), a key cytokine for generation and maintenance of the granuloma, and where gene polymorphisms have been linked to resistance to M. bovis infection (Cheng et al 2016). Gene loci associated with enriched GWAS SNPs for the CHA breed group also included the CILK1 gene (aka ICK) and the Kelch repeat and BTB domain containing 3 gene (KCNJ15), which has been detected as an expression biomarker for human TB (Satproedprai et al 2015); the T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 gene (TCIRG1), a known antimycobacterial host defence gene that has been shown to be a key hub gene associated with IFN-γ stimulation of human macrophages (Steiger et al 2016); and the Von Willebrand factor gene (VWF).…”

Section: And Further Detailed In Supplementarymentioning

confidence: 99%

Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria

Hall

Mullen

McHugo

et al. 2020

Preprint

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Bovine tuberculosis (bTB), caused by infection with Mycobacterium bovis, is a major disease affecting cattle globally as well as being a zoonotic risk to human health. The key innate immune cell that first encounters M. bovis is the alveolar macrophage, previously shown to be substantially reprogrammed during intracellular infection by the pathogen. Here we use multi-omics and network biology approaches to analyse the macrophage transcriptional response to M. bovis infection and identify core infection response pathways and gene modules. These outputs were integrated with results from genome-wide associations of M. bovis infection to enhance the detection of putative genomic variants for disease resistance. Our results show that network-based integration of relevant transcriptomics data can extract additional information from large genome-wide associations and that this approach could also be used to integrate relevant functional genomics outputs with results from genomic association studies for human tuberculosis caused by the related Mycobacterium tuberculosis.

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Interleukin-17 A and F gene polymorphisms affect the risk of tuberculosis: An updated meta-analysis

Cited by 14 publications

References 29 publications

Low Prevalence of Latent Tuberculosis Infection among Contacts of Smear-Positive Adults in Brazil

Low Prevalence of Latent Tuberculosis Infection among Contacts of Smear-Positive Adults in Brazil

RNA Sensing of Mycobacterium tuberculosis and Its Impact on TB Vaccination Strategies

Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria

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