Lack of association between MnSOD Val16Ala polymorphism and breast cancer risk: a meta-analysis involving 58,448 subjects

Qiu, Lixin; Yao, Lei; Chen, Mao; Chen, Bin; Zhan, Ping; Yuan, Hui; Xue, Kai; Zhang, Jian; Hu, Xichun

doi:10.1007/s10549-010-0777-3

Cited by 15 publications

(6 citation statements)

References 31 publications

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“…The discrepancy that occurred may be because our current study was based on a much larger sample size, allowing the more precise detection of the association. In the subgroup analysis by cancer type, we found a significant association between MnSOD Val16Ala polymorphism and elevated prostate cancer risk, and no significant association between this polymorphism and breast cancer, which were consistent with previous meta-analyses [ 131 , 134 – 137 ].…”

Section: Discussionsupporting

confidence: 92%

Association betweenMnSODVal16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls

Wang

Zhu

et al. 2018

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Manganese superoxide dismutase (MnSOD) plays a critical role in the defense against reactive oxygen species. The association between MnSOD Val16Ala polymorphism and cancer risk has been widely studied, but the results are contradictory. To obtain more precision on the association, we performed the current meta-analysis with 33,098 cases and 37,831 controls from 88 studies retrieved from PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of association. We found that the polymorphism was associated with an increased overall cancer risk (homozygous: OR = 1.09, 95% CI = 1.00–1.19; heterozygous: OR = 1.07, 95% CI = 1.02–1.12; dominant: OR = 1.08, 95% CI = 1.02–1.14; and allele comparison: OR = 1.06, 95% CI = 1.02–1.11). Stratification analysis further showed an increased risk for prostate cancer, Asians, Caucasians, population-based studies, hospital-based studies, low quality and high quality studies. However, the increased risk for MnSOD Val16Ala polymorphism among Asians needs further validation based on the false-positive report probability (FPRP) test. To summarize, this meta-analysis suggests that the MnSOD Val16Ala polymorphism is associated with significantly increased cancer risk, which needs further validation in single large studies.

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Section: Discussionsupporting

confidence: 92%

Association betweenMnSODVal16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls

Wang

Zhu

et al. 2018

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“…the association between MDP and BC does not depend on SNP genotypes and vice versa. Associations between BC risk and the MnSOD SNP were found to be not statistically significant, which is in agreement with previous meta-analyses [19,[29][30][31]. For the association between the CAT SNP and BC risk, no meta-analyses were conducted.…”

Section: Discussionsupporting

confidence: 86%

MnSOD and CAT polymorphisms modulate the effect of the Mediterranean diet on breast cancer risk among Greek-Cypriot women

et al. 2015

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“…On the contrary, Qiu et al [19] and Eras-Erdogan et al [20] reported no association. Therefore, it would be interesting to study the correlation between MnSOD gene polymorphism and its enzymatic activity in benign and malignant human breast tissue, which may clarify the role of MnSOD in breast cancer progression.…”

Section: Introductionmentioning

confidence: 99%

Association of Alanine-Valine Manganese Superoxide Dismutase Gene Polymorphism and Microheterogeneity Manganese Superoxide Dismutase Activity in Breast Cancer and Benign Breast Tissue

et al. 2012

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PurposeAlthough the etiology of breast cancer is multifactorial, oxidative stress plays an important role in carcinogenesis. In this study, manganese superoxide dismutase (MnSOD) gene polymorphism and activity were evaluated in benign and breast cancer tissue.MethodsOne hundred and one females were enrolled in this study, 65 who were histopathologically diagnosed with breast cancer and 46 who were benign patients. MnSOD enzyme activity was determined using an indirect competitive inhibition assay and MnSOD gene polymorphism using poly merase chain reaction and agarose gel electrophoresis.ResultsMnSOD enzymatic activity (79.83±42.14) was lower in breast cancer tissue compared to benign tumors (236.18±46.37). At the same time, MnSOD enzymatic activity among Ala/Val patients was significantly lower in breast cancer tissue (39.19±7.33) than in Val/Val malignant breast tumors tissue (96.9±22.9). MnSOD enzymatic activity was significantly lower in Val/Val cancer tissue (96.9±22.9) than in benign tissue (255.44±42.7).ConclusionBreast cancer tumors contain less MnSOD than benign breast samples. Patients with Ala/Val polymorphism had reduced MnSOD activity compared to patients with Val/Val breast cancer. Ala/Val gene polymorphism may be a risk factor associated with more advanced breast cancer stage. MnSOD gene polymorphism Ala/Val may be a risk factor associated with more advanced breast cancer stage, and reduction of MnSOD activity may be a mechanism of the progression of benign to malignant tumors. Further investigations are needed to evaluate the role of MnSOD in breast cancer progression.

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Lack of association between MnSOD Val16Ala polymorphism and breast cancer risk: a meta-analysis involving 58,448 subjects

Cited by 15 publications

References 31 publications

Association betweenMnSODVal16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls

Association betweenMnSODVal16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls

MnSOD and CAT polymorphisms modulate the effect of the Mediterranean diet on breast cancer risk among Greek-Cypriot women

Association of Alanine-Valine Manganese Superoxide Dismutase Gene Polymorphism and Microheterogeneity Manganese Superoxide Dismutase Activity in Breast Cancer and Benign Breast Tissue

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