MnSOD and CAT polymorphisms modulate the effect of the Mediterranean diet on breast cancer risk among Greek-Cypriot women

Kakkoura, Maria G.; Demetriou, Christiana A.; Loizidou, Maria A.; Loucaides, Giorgos; Neophytou, Ioanna; Malas, Simon; Kyriacou, Kyriacos; Hadjisavvas, Andreas

doi:10.1007/s00394-015-0971-5

Cited by 33 publications

(29 citation statements)

References 42 publications

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“…In the same year, Kocabaş et al (35) also carried out another case-control study, including 103 patients and 84 controls, demonstrating a similar result to Bergman et al (32); however, no significant difference about the risk of allele T and C was observed. Furthermore, the majority of other publications suggested that the SOD2 Val-16Ala could not increase or decrease breast cancer risk and survival (26)(27)(28)(29)(30)(31)33,34,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50).…”

Section: Discussionmentioning

confidence: 99%

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There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival

Wang

Liu

Zhou

et al. 2017

Molecular and Clinical Oncology

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Abstract. Breast cancer is the most common diagnosed cancer among females worldwide. Superoxide dismutase 2 (SOD2), an antioxidant enzyme, may break the balance between the oxidant and antioxidant system to induce various diseases. The present study aimed to clarify the association between the SOD2 Val-16Ala polymorphism and breast cancer risk or survival. Thus, a meta-analysis of the relevant articles retrieved from PubMed and EMBASE databases was conducted to illuminate the association with odd ratios (ORs) or hazards ratios (HRs). A total of 26 eligible publications (n=38,008) were available in risk analysis and eight publications ( The present meta-analysis indicated that there was no significant relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival, although in Caucasian patients, the SOD2 TT genotype may marginally decrease the risk of breast cancer in comparison to the CT + CC genotype.

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Section: Discussionmentioning

confidence: 99%

“…Subsequently, two relative meta-analyses were published in 2011 and 2012, but all of the included studies and cohorts were carried out before 2009 (52,54). From 2010-2016, there were another eight studies published, and so the present meta-analysis was conducted (43)(44)(45)(46)(47)(48)(49)(50).…”

Section: Discussionmentioning

confidence: 99%

There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival

Wang

Liu

Zhou

et al. 2017

Molecular and Clinical Oncology

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“…11 Nonetheless, additional studies suggest that fruits and vegetables may minimize the risk of diseases associated with Val16Ala-SOD2 SNP. [12][13][14][15] Because fruits contain a large number of polyphenols and micronutrients with antioxidant action, two studies involving in vitro analysis were conducted to evaluate the effect of isolated molecules (resveratrol and seleno-L-methionine, SeMet) on oxidative modulation of peripheral-blood mononuclear cells (PBMCs) with different Val16Ala-SOD2 genotypes. 16,17 The results suggested that, mainly SeMet can exert a major antioxidant effect in both homozygous genotypes by modulation of GPX and of other antioxidant molecules.…”

Section: Figurementioning

confidence: 99%

The antioxidant effect of Brazil nut (Bertholletia excelsa) is influenced by a genetic superoxide-hydrogen peroxide imbalance in healthy humans

Barbisan¹

2018

JNHFE

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“…The higher iron and low vegetable intake in TT (Val/Val) carriers was associated with increased risk of aggressive prostate cancer (Choi et al 2008 ). In Greek-Cypriot women, high fish and vegetable intake reduced breast cancer risk in TT genotypes (Kakkoura et al 2015 ). As for other diseases, the TT genotype was associated with CHD in females but not males (Jones et al 2010 ), and with CHD in hereditary hemochromatosis patients (Valenti et al 2004 ), thus suggesting a GxG impact.…”

Section: Gene-environment Interaction and Other Factorsmentioning

confidence: 99%

Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants

et al. 2015

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Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. Here we argue that trade-off-like and conditional effects of genes can play central role in this phenomenon and in determining longevity. Such effects may occur as result of: (i) antagonistic influence of gene on the development of different health disorders; (ii) change in effect of gene on vulnerability to death with age (especially, from “bad” to “good”); (iii) gene-gene interaction; and (iv) gene-environment interaction, among other factors. Review of current knowledge provides many examples of genetic factors that may favor the risk of one disease but reduce chances of developing another serious health condition, or improve survival from it. Factors that may increase risk of a major disease but attenuate manifestation of physical senescence are also discussed. Overall, available evidence suggests that influence of a genetic variant on longevity may be negative, neutral or positive, depending on a delicate balance of the detrimental and beneficial effects of such variant on multiple health and aging related traits. This balance may change with age, internal and external environments, and depend on genetic surrounding. We conclude that trade-off-like and conditional genetic effects are very common and may result in situations when a disease “risk allele” can also be a pro-longevity variant, depending on context. We emphasize importance of considering such effects in both aging research and disease prevention.

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MnSOD and CAT polymorphisms modulate the effect of the Mediterranean diet on breast cancer risk among Greek-Cypriot women

Abstract: Our results demonstrate that the antioxidative effects of the MD against BC risk may be enhanced by the wild-type alleles of the MnSOD or CAT SNPs among Greek-Cypriot women.

Cited by 33 publications

References 42 publications

There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival

There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival

The antioxidant effect of Brazil nut (Bertholletia excelsa) is influenced by a genetic superoxide-hydrogen peroxide imbalance in healthy humans

Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants

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