Association between<i>MnSOD</i>Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls

Wang, Ping; Zhu, Yanfeng; Xi, Shoumin; Li, Sanqiang; Zhang, Yanle

doi:10.1155/2018/3061974

Cited by 15 publications

(10 citation statements)

References 131 publications

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“…Overall results indicated that SOD Val16Ala polymorphism is correlated with increased urological cancer susceptibility, especially for prostate cancer, which is consistent with previous findings. [14,33,55]. In stratified analysis by race, we observed similar findings in Caucasians and mixed populations, but not in Asians and Africans.…”

Section: Discussionsupporting

confidence: 69%

Association between SOD2 V16A variant and urological cancer risk

Zhang

Tang

et al. 2020

Aging

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Background: The correlation between superoxide dismutase 2 (SOD2) V16A variant and urological cancer susceptibility has been widely studied, however, with divergent results. Results: Totally, 9,910 cancer patients and 11,239 control subjects were enrolled. V16A variant is associated with an increased susceptibility to urological cancer (A-allele vs. V-allele: OR = 1.06, 95% CI = 1.00 -1.13, P = 0.047; AA+AV vs. VV: OR = 1.09, 95% CI = 1.02 -1.16, P = 0.008), especially for prostate cancer (PCa). Serum SOD2 level of PCa patients with VV+VA genotypes was lower than in those with AA genotypes. SOD2 expression is downregulated in both prostate and bladder cancer, as compared to the control. Furthermore, SOD2 was found to be downregulated in more advanced PCa participants, as compared to the ones in early stages. PCa subjects with low SOD2 expression displayed a shorter disease-free survival (DFS) time compared to that of the high SOD2 expression counterparts. Conclusions: The SOD2 V16A variant may be associated with increased urological cancer susceptibility, especially for prostate cancer. Methods: A pooled analysis utilizing odds ratios (ORs), in silico tools and ELISA was adopted to demonstrate this association. We also used immunohistochemical staining (IHS) to assess SOD2 expression.

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Section: Discussionsupporting

confidence: 69%

Association between SOD2 V16A variant and urological cancer risk

Zhang

Tang

et al. 2020

Aging

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“…However, Wang's 2018 study showed that MnSOD gene polymorphisms were associated with cancer as a whole (breast, prostate, lung, bladder, pancreatic cancer, colorectal, ovarium, hepatocellular carcinoma, and non-Hodgkin's lymphoma) and subgroup analysis found an association between MnSOD gene polymorphisms and prostate cancer and no association with breast cancer. However, previous metanalytic studies by Kang in 2015 and Bang in 2008 showed that there was no relationship between MnSOD gene polymorphisms and overall cancer incidence [8], [9], [10].…”

Section: Resultsmentioning

confidence: 99%

Relationship between Superoxide Dismutase Manganese Gene Polymorphism and Eye Tumors

Lubis

Adella

Lubis

2021

Open Access Maced J Med Sci

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ABSTRACT Background: Orbital tumor in Indonesia is one of the eye health problems that can cause blindness. The impact caused by orbital tumors on patients is quite large because it can result in blindness and even death due to its metastatic nature. The role that SOD plays in cancer biology is not well understood, most studies showing a more oxidative state, characterized by increased intracellular ROS, particularly superoxide. Objective: To determine the relationship between Manganese Superoxide Dismutase (SOD2) gene polymorphisms and the incidence of orbital tumors in Medan. Methods: This study is an analytic observational study with a cross-sectional data collection method using controls. Comparisons were made between the control group and the observed group to see the relationship between SOD2 polymorphisms and the risk of orbital tumor incidence in Medan. The ophthalmic examination, anterior and posterior segments, and assessment of CT orbit if deemed necessary for the orbital tumor patients. Histopathological examination was done by the Pathologist. Blood samples was taken for polymorphism examination on extracted DNA using the Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) methods. Results: About 30 patients that met the inclusion criterias. Laterality, the left eye is more likely to suffer from tumors when compared to the right eye. This study found as many as 16 patients, while malignant tumors was 14 patients. There was a relationship between the MnSOD gene polymorphism and the incidence of orbital tumors (p <0.001), there was a relationship between the MnSOD gene polymorphism and the incidence of orbital tumors in the female sex (p <0.001) Conclusion: There was a relationship between MnSOD gene polymorphisms and the incidence of orbital tumors (p <0.001)

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“…MnSOD protein is an antioxidant enzyme that participates in the mitochondrial respiration by detoxifying the free radical superoxides [92]. In relation with the critical role of MnSOD in the defense against reactive oxygen species, it has been implicated in different diseases, such as type 2 diabetes, cardiovascular diseases, and cancer [93][94][95]. For instance, MnSOD overexpression originated a reduction of EV-associated PYGB protein, being EVs containing PYGB, a sensitive biomarker of cardiac injury [96].…”

Section: Manganese Superoxide Dismutase (Mnsod)mentioning

confidence: 99%

Metabolic Nano-Machines: Extracellular Vesicles Containing Active Enzymes and Their Contribution to Liver Diseases

2019

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Purpose of Review The field of extracellular vesicles is growing exponentially because of the important role that these extracellular organelles had on cell to cell communication, triggering a large number of review compilations focusing on different aspects of their biology. Although their importance as effectors or potential biomarkers is well covered, the highlight of extracellular vesicles as carriers of active enzymes which have the capability to transform the surrounding media is less covered by bibliographic studies. In the present review, we focus our attention on enzymatic activity carried by vesicles, with special attention on their contribution to liver conditions. Recent Findings Extracellular vesicles are circulating membrane-bound entities, characterized by a specific cargo. This cargo depends on the parental cell and the stimulus that triggers their release. Interestingly, the cargo includes active enzymes which had the ability of transforming the extracellular environment. Among them, extracellular vesicles derived from hepatocytes harbor specific liver enzymes that may cause an impact in the surrounds and target cells. Summary In this review, we summarize different active enzymes described in extracellular vesicles and we focus on enzymatic activities associated to liver damage. Since their release increases under liver damage conditions, their activity impact could play a role in the pathogenesis of liver and liver-associated diseases. Numerous examples in different liver conditions provided evidence of the potential of extracellular vesicles as therapeutic targets.

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Association betweenMnSODVal16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls

Cited by 15 publications

References 131 publications

Association between SOD2 V16A variant and urological cancer risk

Association between SOD2 V16A variant and urological cancer risk

Relationship between Superoxide Dismutase Manganese Gene Polymorphism and Eye Tumors

Metabolic Nano-Machines: Extracellular Vesicles Containing Active Enzymes and Their Contribution to Liver Diseases

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