Lack of Association Between Aphthous Ulcers and Helicobacter pylori

Chapman, Michael

doi:10.1001/archderm.134.12.1634-a

Cited by 10 publications

(7 citation statements)

References 3 publications

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“…Some studies have suggested a possible involvement of Helicobacter pylori in RAS development (11). However, other studies have not found any significant association between this bacteria and RAS (8, 9, 14, 15). Although methodological differences may explain such disparity, the role of H. pylori in RAS pathogenesis is still unclear.…”

mentioning

confidence: 75%

“…Many local and systemic factors have been associated with RAS. Although, for many years, there has been great interest in the possible role of viruses and bacteria in the pathogenesis of RAS (3–15), to date no substantial data exists to establish a microbial aetiology for RAS. Some studies have suggested a possible involvement of Helicobacter pylori in RAS development (11).…”

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confidence: 99%

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Helicobacter pylori DNA in recurrent aphthous stomatitis

Victória¹,

Kalapothakis

Silva

et al. 2003

J Oral Pathology Medicine

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confidence: 75%

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confidence: 99%

Helicobacter pylori DNA in recurrent aphthous stomatitis

Victória¹,

Kalapothakis

Silva

et al. 2003

J Oral Pathology Medicine

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“…Porter et al (21) conducted a study of the frequency of serum anti-H. pylori IgG antibodies in patients with RAU and found that the frequency of anti-H. pylori seropositivity was not significantly greater in patients with RAU compared with other ulcerated oral mucosal lesions and the controls. In a study with a small sample size, Chapman et al found that all four RAU biopsies were negative for urease activity (22). By using a culture technique recognized as the gold standard for diagnosis of H. pylori infection (23), Shimoyama et al reported that all twelve samples from patients with RAU were found to be culture-negative (19).…”

Section: Discussionmentioning

confidence: 99%

Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR

Iamaroon

Chaimano

Linpisarn

et al. 2003

Journal of Oral Science

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Recurrent aphthous ulceration (RAU) is the most common lesion of the oral mucosa. Although many factors have been postulated as etiological factors for RAU, the role of Helicobacter pylori as a causative agent of RAU remains controversial. We therefore investigated the association of H. pylori and RAU by a highly sensitive technique, nested polymerase chain reaction (PCR), in 22 patients with RAU with ages ranging from 12-36 years. Samples were brushed from the lesions and the dorsum of the tongue of each patient. In addition, samples from the dorsum of the tongue of 15 normal individuals with ages ranging from 13-40 years were used as controls. The results showed that only one sample from a lesion (4.5 %) and one sample from the tongue (4.5 %) of two different patients with RAU were positive for H. pylori. In the control group, 3 samples (20 %) were positive for H. pylori. These findings suggest that H. pylon does not play a role in the pathogenesis of RAU and the dorsum of the tongue may be a reservoir of H. pylori in some individuals. (J.

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“…As shown in Table 2 there was a large variation in the number of patients evaluated in each study as well as the methods used to collect the samples or to identify H. pylori . While in some studies biopsies of the lesions were used ( 7 - 9 ), others used swabs ( 10 - 16 ). Ten out of fifteen studies did not demonstrate a statistically significant association between H. pylori and the presence of RAS ( 7 , 8 , 10 , 12 - 18 ).…”

Section: Resultsmentioning

confidence: 99%

Recurrent aphthous stomatitis and Helicobacter pylori

Gomes

Gomez²,

Zina³

et al. 2016

Med Oral

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BackgroundRecurrent aphthous stomatitis (RAS) is a recurrent painful ulcerative disorder that commonly affects the oral mucosa. Local and systemic factors such as trauma, food sensitivity, nutritional deficiencies, systemic conditions, immunological disorders and genetic polymorphisms are associated with the development of the disease. Helicobacter pylori (H. pylori) is a gram-negative, microaerophile bacteria, that colonizes the gastric mucosa and it was previously suggested to be involved in RAS development. In the present paper we reviewed all previous studies that investigated the association between RAS and H. pylori.Material and MethodsA search in Pubmed (MEDLINE) databases was made of articles published up until July 2015 using the following keywords: Helicobacter Pylori or H. pylori and RAS or Recurrent aphthous stomatitis.ResultsFifteen experimental studies that addressed the relationship between infection with H. pylori and the presence of RAS and three reviews, including a systematic review and a meta-analysis were included in this review. The studies reviewed used different methods to assess this relationship, including PCR, nested PCR, culture, ELISA and urea breath test. A large variation in the number of patients included in each study, as well as inclusion criteria and laboratorial methods was observed. H. pylori can be detected in the oral mucosa or ulcerated lesion of some patients with RAS. The quality of the all studies included in this review was assessed using levels of evidence based on the University of Oxford’s Center for Evidence Based Medicine Criteria.ConclusionsAlthough the eradication of the infection may affect the clinical course of the oral lesions by undetermined mechanisms, RAS ulcers are not associated with the presence of the bacteria in the oral cavity and there is no evidence that H. pylori infection drives RAS development. Key words:Campylobacter, elisa, h. pylori, Helicobacter Pylori, RAS, recurrent aphthous stomatitis, PCR.

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Lack of Association Between Aphthous Ulcers and Helicobacter pylori

Cited by 10 publications

References 3 publications

Helicobacter pylori DNA in recurrent aphthous stomatitis

Helicobacter pylori DNA in recurrent aphthous stomatitis

Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR

Recurrent aphthous stomatitis and Helicobacter pylori

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