<i>Helicobacter pylori</i> DNA in recurrent aphthous stomatitis

Victória, Júnia Maria Netto; Kalapothakis, Evanguedes; Silva, Jeane de Fátima Correia; Gomez, Ricardo Santiago

doi:10.1034/j.1600-0714.2003.00136.x

Cited by 37 publications

(28 citation statements)

References 34 publications

(36 reference statements)

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“…Despite the fact that stomach ulcers and RAS are linked to dysregulated immune functions, molecular studies that identified H pylori in both affected and non-affected mucosa of RAS patients found no association with RAS 24,25 . Interestingly, another study 26 reported that eradication of H pylori in RAS patients positively correlated with increased Vitamin B12 levels and decreased number of aphthous lesions [26][27][28][29] .…”

Section: Microbial Factorsmentioning

confidence: 95%

Recurrent aphthous stomatitis

Akintoye

Greenberg

2005

Dental Clinics of North America

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Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative disease affecting the oral mucosa. It occurs mostly in healthy individuals and has atypical clinical presentation in immunocompromised individuals. The etiology of RAS is still unknown, but several local, systemic, immunologic, genetic, allergic, nutritional, and microbial factors, as well as immunosuppressive drugs, have been proposed as causative agents. Clinical management of RAS is based on severity of symptoms, frequency, size and number of lesions using topical and systemic therapies. The goals of therapy are to decrease pain and ulcer size, promote healing and decrease frequency of recurrence.

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Section: Microbial Factorsmentioning

confidence: 95%

Recurrent aphthous stomatitis

Akintoye

Greenberg

2005

Dental Clinics of North America

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“…The literature suggests that minor aphthous stomatitis is the most common form of RAS. 10,11 Out of the total 27 patients in the study groups II and III, 12 patients had a recurrence of ulcers every 15 days to 1 month, 8 had recurrence every 1 to 2 months, and 7 patients had recurrence every 2 to 3 months. The findings of this study show that frequency of recurrence of ulcers was more in between 1 and 2 months, which is in accordance with the study carried out by Ship et al 12 The present study investigated the association of H. pylori in patients with only RAS (study group II) and compared with healthy control group I subjects.…”

Section: Resultsmentioning

confidence: 99%

A Clinical and Microbiological Evaluation of Helicobacter pylori in Recurrent Aphthous Stomatitis

Rajendra

Purnachandra²,

Patel

et al. 2017

The Journal of Contemporary Dental Practice

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Aim:The aim of this study is to evaluate the association of Helicobacter pylori in recurrent aphthous stomatitis (RAS) with or without peptic ulcer. Materials and methods:A total of 42 patients were selected for the present study from outpatient Department of Oral Medicine, and divided into control (group I) and test groups (groups II, III). A total number of 15 patients suffering from RAS based on history and clinical examination was selected as group II. A total number of 12 patients suffering concomitantly from RAS and duodenal ulcer based on history and clinical examination were selected as group III. A total number of 15 healthy subjects were selected as controls in group I. All selected subjects belonged to the age group of 16 to 45 years.

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“…In one study, H. pylori was detected in patients with aphthous stomatitis in 52% of cases (15). In another study, 38.9% of patients with recurrent aphthous stomatitis showed H. pylori positivity (16). Previous studies showed that SS was triggered by environmental factors such as a viral infection (17).…”

Section: Introductionmentioning

confidence: 99%

The Possible Role of Helicobacter pylori in the Development of Sjogren's Syndrome and Chronic Sialadenitis

Esfahani¹,

Irani²,

Sabeti³

et al. 2015

Avicenna J Dent Res

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Background: Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, which can be triggered by environmental factors such as viral infection. Chronic obstructive sialadenitis is the most common type of chronic sialadenitis and many different bacterial infections develop as a result of ductal obstruction. Objectives: This study was conducted to assess the association of these lesions with the presence of Helicobacter pylori. Patients and Methods: A total of 56 biopsies diagnosed as Sjögren's syndrome (SS) and chronic sialadenitis (CS) due to sialolithiasis in submandibular glands, sublingual and minor salivary glands were selected (56 samples as examined group and 20 samples as control group). All the paraffin blocks were cut for hematoxylin and eosin (H and E) staining to confirm the diagnoses and then the samples were prepared for immunohistochemistry (IHC) staining to detect H. pylori. Chi-squared test was used for statistical analysis. Results: Chi-squared test showed a significant difference between H. pylori positivity in the groups examined (P = 0.046) and between SS group and normal tissue samples (P = 0.013). There was no significant difference between gender and H. pylori positivity in examined groups examined (P = 0.574, P = 0.543, respectively). In addition, there was no significant difference between gender and H. pylori positivity in SS group (P = 0.119, P = 0.331, respectively) also in CS group (P = 0.981, P = 0.571). Conclusions: Bacterial infection has been suggested in the pathogenesis of both SS and CS. In addition, H. pylori is a resident of the oral cavity, thus may be involved in the development and progression of these lesions. Hence, search for H. pylori antibody in blood of patients with SS is suggested.

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Helicobacter pylori DNA in recurrent aphthous stomatitis

Abstract: The present study does not give support to the assumption that H. pylori could be involved in RAS development.

Cited by 37 publications

References 34 publications

Recurrent aphthous stomatitis

Recurrent aphthous stomatitis

A Clinical and Microbiological Evaluation of Helicobacter pylori in Recurrent Aphthous Stomatitis

The Possible Role of Helicobacter pylori in the Development of Sjogren's Syndrome and Chronic Sialadenitis

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