Lack of Adverse Effect of Silicone Implant on Sarcoidosis of the Breast

Riefkohl, Ronald; Roberts, Toni L.; McCarty, Kenneth S.

doi:10.1097/00006534-198508000-00023

Cited by 8 publications

(3 citation statements)

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“…There are more than 48 case reports of sarcoidosis of the breast [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. There are two reports of patients with breast sarcoidosis who had silicone implants without exacerbation of their disease and who did not experience any unusual periprosthetic complications.…”

Section: Discussionmentioning

confidence: 99%

“…One patient with silicone implants had progressive and non-responsive symptoms of sarcoidosis that did not remit until the implants were removed. One report describes a patient who presented with sarcoidosis of the skin, without systemic involvement [ 2 , 46 , 47 , 48 ]. A large study by Watad et al in a cohort that contained over 24,000 women with breast implants matched with over 98,000 women without breast implants, showed a higher risk of developing sarcoidosis following silicone breast prosthesis implantation (OR 1.98) [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

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A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis

Todorov

Bakker

Smith

et al. 2021

IJERPH

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Foreign body giant cell (FBGC) reaction to silicone material in the lymph nodes of patients with silicone breast implants has been documented in the literature, with a number of case reports dating back to 1978. Many of these case reports describe histologic features of silicone lymphadenopathy in regional lymph nodes from patients with multiple sets of different types of implants, including single lumen smooth surface gel, single lumen textured surface gel, single lumen with polyethylene terephthalate patch, single lumen with polyurethane coating, and double lumen smooth surface. Only one other case report described a patient with highly-cohesive breast implants and silicone granulomas of the skin. In this article, we describe a patient with a clinical presentation of systemic sarcoidosis following highly cohesive breast implant placement. Histopathologic analysis and Confocal Laser Raman Microprobe (CLRM) examination were used to confirm the presence of silicone in the axillary lymph node and capsular tissues. This is the first report where chemical spectroscopic mapping has been used to establish and identify the coexistence of Schaumann bodies, consisting of calcium oxalate and calcium phosphate minerals, together with silicone implant material.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis

Todorov

Bakker

Smith

et al. 2021

IJERPH

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“…However, the autologous free flap success rate can be up to 100% in these cases 43 . Riefkohl et al 44 described 2 cases of breast reconstruction with silicone implants after resection of sarcoidosis breast mass, without apparent disease activation or exacerbation in the follow-up.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis Presenting as Late Seroma Mimicking Breast Implant–Associated Anaplastic Large Cell Lymphoma

Ibarra

Vallejo²,

Rivera³

et al. 2021

Ann Plast Surg

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Late seroma related to breast silicone implants is a rare complication. Interest for its characterization has grown after its association with the recently described breast implant–associated anaplastic large cell lymphoma. The differential diagnosis includes infectious diseases, mechanical and traumatic causes, tumors, postpartum seroma, and inflammatory, allergic, or idiopathic causes. Sarcoidosis has been associated with breast silicone implants over the last decades, but it has never been reported as a cause of breast effusion. We describe a rare presentation of sarcoidosis as a late breast implant seroma simulating the clinical features and radiologic findings of breast implant–associated anaplastic large cell lymphoma and highlight that sarcoidosis can be suspected by the presence of nonnecrotizing epithelioid granulomas in the cytology, with a characteristic inverted ratio of CD4/CD8 T cells. The aims of this article are to review the current evidence about sarcoidosis related to silicone implants and breast cancer, provide a new alternative in the differential diagnosis of late seroma, and advise the scientific community how early implant removal can improve the disease.

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Self-expanding prostheses complicating augmentation mammoplasties

Signorini¹,

Grisotti²,

Ponzielli³

et al. 1994

Aesth. Plast. Surg.

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A new and serious complication was experienced by patients of three independent surgeons following routine augmentation procedures. In each case reported, double-lumen prostheses had been used. All cases were reoperated with a diagnosis of capsular contracture. However, at surgery it was found that the outer lumen of the prostheses had overfilled with 60-160 cc of interstitial fluid, probably because of an osmotic gradient. The possible causes of this unfortunate complication are considered.

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Lack of Adverse Effect of Silicone Implant on Sarcoidosis of the Breast

Cited by 8 publications

References 0 publications

A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis

A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis

Sarcoidosis Presenting as Late Seroma Mimicking Breast Implant–Associated Anaplastic Large Cell Lymphoma

Self-expanding prostheses complicating augmentation mammoplasties

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