Label-free bioassay with graphene oxide-based fluorescent aptasensors: A review

Ma, Ke; Li, Xing; Xu, Bin; Tian, Wenjing

doi:10.1016/j.aca.2021.338859

Cited by 35 publications

(10 citation statements)

References 112 publications

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“…They feature distinct characteristics such as compact size, low cost, high specificity, facile chemical modification, and most importantly extraordinary flexibility. These are capable of binding specific targets with high affinity, specificity, and sensitivity [ 26 , 27 ]. The target molecule can be as simple as a metal ion, and can be as complex as large protein molecules such as cardiac troponin, or even cells [ 28 , 29 , 30 , 31 , 32 ].…”

Section: Label and Label-free Aptasensorsmentioning

confidence: 99%

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

et al. 2022

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Viral infections are becoming the foremost driver of morbidity, mortality and economic loss all around the world. Treatment for diseases associated to some deadly viruses are challenging tasks, due to lack of infrastructure, finance and availability of rapid, accurate and easy-to-use detection methods or devices. The emergence of biosensors has proven to be a success in the field of diagnosis to overcome the challenges associated with traditional methods. Furthermore, the incorporation of aptamers as bio-recognition elements in the design of biosensors has paved a way towards rapid, cost-effective, and specific detection devices which are insensitive to changes in the environment. In the last decade, aptamers have emerged to be suitable and efficient biorecognition elements for the detection of different kinds of analytes, such as metal ions, small and macro molecules, and even cells. The signal generation in the detection process depends on different parameters; one such parameter is whether the labelled molecule is incorporated or not for monitoring the sensing process. Based on the labelling, biosensors are classified as label or label-free; both have their significant advantages and disadvantages. Here, we have primarily reviewed the advantages for using aptamers in the transduction system of sensing devices. Furthermore, the labelled and label-free opto-electrochemical aptasensors for the detection of various kinds of viruses have been discussed. Moreover, numerous globally developed aptasensors for the sensing of different types of viruses have been illustrated and explained in tabulated form.

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Section: Label and Label-free Aptasensorsmentioning

confidence: 99%

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

et al. 2022

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“…Compared with other specific recognition molecules, such as enzymes and antibodies, aptamers have the advantages of flexible structure and chemical composition, diverse modification and sensing strategies, and can be adapted to a variety of detection systems [41][42][43][44][45][46][47][48] . Moreover, aptamers have been continually combined with emerging materials, such as carbon nanomaterials [49][50][51] and metal nanoparticles [52][53][54] , and have found remarkable applications in a variety of fields, including cell cancer diagnosis [55][56][57] , targeted drug innovation [58][59][60] , judicial detection [61][62][63] and many others.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors

Tang

Liu

Jiang

2022

Chem. Res. Chin. Univ.

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ighly selective, sensitive, and stable biosensors are essential for the molecular level understanding of many physiological activities and diseases. Electrochemical aptamer-based (E-AB) sensor is an appealing platform for measurement in biological system, attributing to the combined advantages of high selectivity of the aptamer and high sensitivity of electrochemical analysis. This review summarizes the latest development of E-AB sensors, focuses on the modification strategies used in the fabrication of sensors and the sensing strategies for analytes of different sizes in biological system, and then looks forward to the challenges and prospects of the future development of electrochemical aptamerbased sensors.

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“…Among them, fluorescence-based aptasensors are the most common type, featuring simplicity, fast response, high sensitivity, and universal applicability ( 17 , 18 ). However, most of them require labeling aptamers or modifying bases with fluorescent groups, which are time-consuming and expensive, and the affinity of the aptamer to the target and the detection sensitivity are affected ( 19 ). Therefore, label-free fluorescent aptasensors have attracted much interest due to their flexible design and versatility.…”

Section: Introductionmentioning

confidence: 99%

Self-assembly and label-free fluorescent aptasensor based on deoxyribonucleic acid intercalated dyes for detecting lactoferrin in milk powder

Liu

Qin

et al. 2022

Front. Nutr.

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Label-free bioassay with graphene oxide-based fluorescent aptasensors: A review

Cited by 35 publications

References 112 publications

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors

Self-assembly and label-free fluorescent aptasensor based on deoxyribonucleic acid intercalated dyes for detecting lactoferrin in milk powder

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