Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors

Abstract

ighly selective, sensitive, and stable biosensors are essential for the molecular level understanding of many physiological activities and diseases. Electrochemical aptamer-based (E-AB) sensor is an appealing platform for measurement in biological system, attributing to the combined advantages of high selectivity of the aptamer and high sensitivity of electrochemical analysis. This review summarizes the latest development of E-AB sensors, focuses on the modification strategies used in the fabrication of sensors and the sensing strategies for analytes of different sizes in biological system, and then looks forward to the challenges and prospects of the future development of electrochemical aptamerbased sensors.

Aptamer-Based Point-of-Care Devices: Emerging Technologies and Integration of Computational Methods

“…Electrochemical methods are advantageous because of their high sensitivity, low detection limit, minimal time consumption, and low cost of equipment [183]. They have received significant attention in developing aptamer-based biosensors due to their low-cost, high sensitivity and selectivity, low detection limits, and the potential to develop flexible POC systems [184][185][186][187].…”

Nanopillar array-based electrochemical aptamer sensor for STX sensitivity detection

“…In recent years, electrochemical sensors based on aptamers, which transduce biological reactions or binding events into an electrical readout, have been used in food, medical, environmental, and other elds due to their simplicity, high sensitivity, rapid detection, and cost effectiveness. 10 Generally, electrochemical aptamer-based sensors are fabricated by immobilizing aptamers that have been modied with a terminal thiol and a redox label on an Au electrode surface via Au-S bonds. 11 To date, numerous electrochemical sensors based on aptamers have been designed for the detection of small molecules, [12][13][14][15] macromolecules, 16 viruses, 17,18 metal ions, 19,20 etc.…”

Triple-Bioinspired Shape Memory Microcavities with Strong and Switchable Adhesion

“…Smart adhesive surfaces with switchable adhesion have gained significant research attention owing to their high potential for use in various applications, including sensors, , soft grippers, and robots. , These surfaces exhibit strong adhesion and can be selectively detached in response to specific external stimuli such as UV light, magnetic field, electric field, or thermal stimuli, , inducing changes in contact area, mechanical properties, or near-interface properties. For example, gecko-inspired adhesion microstructures have been developed by using photoresponsive liquid crystals .…”