Lab on a Wire: Application of Silicon Nanowires for Nanoscience and Biotechnology

Baraban, Larysa; Zörgiebel, F.; Pahlke, Claudia; Baek, Eunhye; Römhildt, Lotta; Cuniberti, Gianaurelio

doi:10.1007/978-1-4614-8124-9_10

Cited by 5 publications

(4 citation statements)

References 73 publications

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“…There are bottom-up and top-down methods that are utilized for the fabrication of nanowire sensors. As shown in Figure 1D, the bottom-up methods have been used to grow high-quality nanowires commonly on Si wafers [40]. Although most nanowires are cylindrical in shape, existing bottom-up techniques are capable of varying their cross-sectional shape, producing round, square, and triangular versions [41].…”

Section: Working Principle and Fabrication Processmentioning

confidence: 99%

Nanowire-Based Biosensors: From Growth to Applications

et al. 2018

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Over the past decade, synthesized nanomaterials, such as carbon nanotube, nanoparticle, quantum dot, and nanowire, have already made breakthroughs in various fields, including biomedical sensors. Enormous surface area-to-volume ratio of the nanomaterials increases sensitivity dramatically compared with macro-sized material. Herein we present a comprehensive review about the working principle and fabrication process of nanowire sensor. Moreover, its applications for the detection of biomarker, virus, and DNA, as well as for drug discovery, are reviewed. Recent advances including self-powering, reusability, sensitivity in high ionic strength solvent, and long-term stability are surveyed and highlighted as well. Nanowire is expected to lead significant improvement of biomedical sensor in the near future.

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Section: Working Principle and Fabrication Processmentioning

confidence: 99%

Nanowire-Based Biosensors: From Growth to Applications

et al. 2018

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“…In these regards, printable silicon nanowire field-effect transistor (SiNW FET) sensors represent a great potential for POC biosensors, because they offer the possibility of a cost-efficient wafer-scale production, CMOS compatibility [11], miniaturized integration on a chip, and detection process in real-time [12]. Since the key component of such devices are 1D nanoscale sized elements, the advantages of ultrahigh sensitivity of the measurements down to the fM level [13,14] given by the channel full depletion capability, in combination with the remarkably high signal-to-noise ratio, are achievable.…”

Section: Introductionmentioning

confidence: 99%

Gating Hysteresis as an Indicator for Silicon Nanowire FET Biosensors

et al. 2018

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Abstract:We present a biosensor chip with integrated large area silicon nanowire-based field effect transistors (FET) for human α-thrombin detection and propose to implement the hysteresis width of the FET transfer curve as a reliable parameter to quantify the concentration of biomolecules in the solution. We further compare our results to conventional surface potential based measurements and demonstrate that both parameters distinctly respond at a different analyte concentration range. A combination of the two approaches would provide broader possibilities for detecting biomolecules that are present in a sample with highly variable concentrations, or distinct biomolecules that can be found at very different levels. Finally, we qualitatively discuss the physical and chemical origin of the hysteresis signal and associate it with the polarization of thrombin molecules upon binding to the receptor at the nanowire surface.

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“…In these regards, recently proposed integrated nanosensors, i.e., ion-sensitive field effect transistors (ISFETs), offer real-time and ultrasensitive detection of disease markers or pathogens − as well as monitoring of multiple physiological parameters, like glucose level or pH . Although the ISFET principle goes back to the 1970s, , it found a new fascinating realization in the past decade with utilizing silicon nanowires (SiNWs) − ,− (Figure b) carbon nanotubes, etc., as sensor building blocks. In comparison with planar semiconducting elements, the performance of nanowire devices, namely the sensitivity, ,,,, is significantly improved by reducing their size and increasing surface-to-volume ratio .…”

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confidence: 99%

“…Although the ISFET principle goes back to the 1970s, , it found a new fascinating realization in the past decade with utilizing silicon nanowires (SiNWs) − ,− (Figure b) carbon nanotubes, etc., as sensor building blocks. In comparison with planar semiconducting elements, the performance of nanowire devices, namely the sensitivity, ,,,, is significantly improved by reducing their size and increasing surface-to-volume ratio . Silicon nanowire-based FETs reveal great electrical characteristics with high output current and low power dissipation ,, and are CMOS compatible. , While being an excellent candidate for integration as transducers for pH or biomarkers detection in single liquid phase conditions, , to our knowledge SiNW FETs have not been combined with the multiphase droplet-based approach so far.…”

mentioning

confidence: 99%

Compact Nanowire Sensors Probe Microdroplets

et al. 2016

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The conjunction of miniature nanosensors and droplet-based microfluidic systems conceptually opens a new route toward sensitive, optics-less analysis of biochemical processes with high throughput, where a single device can be employed for probing of thousands of independent reactors. Here we combine droplet microfluidics with the compact silicon nanowire based field effect transistor (SiNW FET) for in-flow electrical detection of aqueous droplets one by one. We chemically probe the content of numerous (∼10(4)) droplets as independent events and resolve the pH values and ionic strengths of the encapsulated solution, resulting in a change of the source-drain current ISD through the nanowires. Further, we discuss the specificities of emulsion sensing using ion sensitive FETs and study the effect of droplet sizes with respect to the sensor area, as well as its role on the ability to sense the interior of the aqueous reservoir. Finally, we demonstrate the capability of the novel droplets based nanowire platform for bioassay applications and carry out a glucose oxidase (GOx) enzymatic test for glucose detection, providing also the reference readout with an integrated parallel optical detector.

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Lab on a Wire: Application of Silicon Nanowires for Nanoscience and Biotechnology

Cited by 5 publications

References 73 publications

Nanowire-Based Biosensors: From Growth to Applications

Nanowire-Based Biosensors: From Growth to Applications

Gating Hysteresis as an Indicator for Silicon Nanowire FET Biosensors

Compact Nanowire Sensors Probe Microdroplets

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