La course contre le temps

Mégarbane, Buno; Amoli, A. Mohebbi; Brouland, Jean‐Philippe; Guerin, J.-M.; Toledano, Dorith; Gueye, Pascale; Dupuy, Eric; Baud, Françoise

doi:10.1016/s0248-8663(02)80042-x

Cited by 3 publications

(5 citation statements)

References 4 publications

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“…2 A general review of currently available cyanide poisoning treatments shows a gap in available emergency treatments. 3 The need for a novel, easily handled, and rapidly administratable cyanide poisoning treatment calls for a highly efficient approach due to the acute toxicity of cyanide. Molybdenum's role in biology as the active metal center in xanthine oxidase as an oxo-transfer agent, and in sulfite oxidase where it catalyzes the transformation of sulfite to sulfate, is well documented.…”

Section: Introductionmentioning

confidence: 99%

“…(3) and(6) while the molecular anion was obtained for the monoanions Et 4 N(2) and K(5). The dianions (Et 4 N) 2 (1) and Na 2 (4) retain one cation and are observed as the complex anion plus one cation to form an overall monoanion.…”

mentioning

confidence: 99%

“…Such behavior is known for coordinated amino acids, where the amine group and C=O of the carboxylate of methionine from polymeric structures with first row transition metal ions with unsaturated coordination geometry 34. Compounds (3) and (6) are both neutral but with very different ligand set.Interestingly, the polar DMF ligands in(3) are not displaced by water in aqueous solution, and the compound is quite stable at neutral pH. The Ranking of compounds according to relative toxicity using in vitro approach has great value for guiding synthetic efforts for novel compounds with limited reported literature data.…”

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confidence: 99%

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Cytotoxicity studies of water soluble coordination compounds with a [Mo2O2S2]2+ core

Gretarsdottir

Bobersky

Metzler‐Nolte

et al. 2016

Journal of Inorganic Biochemistry

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Selected molybdenum sulfur compounds with the formulas (M)[Mo2O2S4L] where (Et4N)2(1), L=S4(2-), (Et4N)(2), L=Cp, (3), L=DMF, K(5), L=serine, M=Et4N(+), K(+), Na(+) and [Mo2O2S2L2] where Na2(4), L=cysteine, and (6), L=threonine, were prepared and subjected to cytotoxicity studies in vitro. The results were analyzed to rank the compounds according to their relative cytotoxicity and to correlate the observed toxicity to specific composition. The results guide future efforts to synthesize highly water soluble, non-toxic, compounds. Strong correlation was observed between toxicity and cation selection, as well as selection of biocompatible ligands combined with alkali metal salts. The most toxic compound analyzed showed about 50 times less cytotoxicity than the cisplatin reference compound in HT-29 cells. Preliminary results from in vivo data agree with the ranking obtained in vitro.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Cytotoxicity studies of water soluble coordination compounds with a [Mo2O2S2]2+ core

Gretarsdottir

Bobersky

Metzler‐Nolte

et al. 2016

Journal of Inorganic Biochemistry

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“…Hydrogen cyanide has been used as a chemical warfare agent, most notably during World War I and the Iran-Iraq War (Sauer and Keim, 2001;Mégarbane et al, 2003). Given its volatility and rapidly effective reversal agents, large quantities of the gas are needed to be an effective.…”

Section: Knockdown Gases-hydrogen Cyanidementioning

confidence: 99%

Ophthalmic manifestations and management considerations for emerging chemical threats

Menke,

Ryu,

Justin

et al. 2023

Front. Toxicol.

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Chemical agents have been utilized for centuries in warfare and pose a health threat to civilians and military personnel during armed conflict. Despite treaties and regulations against their use, chemical agent exposure remains a threat and measures to understand their effects and countermeasures for systemic and organ-specific health are needed. Many of these agents have ocular complications, both acute and chronic. This mini-review focuses on key chemical agents including vesicants (mustards, lewisite), nerve agents (sarin, VX), knockdown gasses (hydrogen cyanide), and caustics (hydrofluoric acid). Their ophthalmic manifestations and appropriate treatment are emphasized. Acute interventions include removal of the source and meticulous decontamination, as well as normalization of pH to 7.2–7.4 if alteration of the ocular pH is observed. Besides vigorous lavage, acute therapies may include topical corticosteroids and non-steroid anti-inflammatory therapies. Appropriate personal protective equipment (PPE) and strict donning and doffing protocols to avoid healthcare provider exposure are also paramount in the acute setting. For more severe disease, corneal transplantation, amniotic membrane graft, and limbal stem cell transplantation may be needed. Orbital surgery may be required in patients in whom cicatricial changes of the ocular surface have developed, leading to eyelid malposition. Multidisciplinary care teams are often required to handle the full spectrum of findings and consequences associated with emerging chemical threats.

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“…Certain arguments would tend to implicate pharmacodynamic mechanisms [16][17][18], while others would support pharmacokinetic processes [14]. Very little work in exploring the pharmacokinetic hypothesis has been conducted, mainly because diagnostic means of study and exploration were not available.…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatographic–electrospray ionization mass spectrometric quantitative analysis of buprenorphine, norbuprenorphine, nordiazepam and oxazepam in rat plasma

Pirnay¹,

Hervé²,

Bouchonnet³

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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La course contre le temps

Cited by 3 publications

References 4 publications

Cytotoxicity studies of water soluble coordination compounds with a [Mo2O2S2]2+ core

Cytotoxicity studies of water soluble coordination compounds with a [Mo2O2S2]2+ core

Ophthalmic manifestations and management considerations for emerging chemical threats

Liquid chromatographic–electrospray ionization mass spectrometric quantitative analysis of buprenorphine, norbuprenorphine, nordiazepam and oxazepam in rat plasma

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