La carcinine (β-alanyl-histamine), substance caracteristique du cȩur de Carcinus maenas (L.): Synthese chimique et recherche d'un role eventuel dans la regulation cardiaque du crustace

Constitutive activity of N-β-alanyl-catecholamine ligase in insect brain

“…To our knowledge, this is the first report of synthesis of these substances by a brain-associated enzyme from any biological system. Since we previously described the synthesis of sarcophagine (N-␤-alanyl-tyrosine) by the epidermis-associated enzyme [16], we tested the synthesis of this and other known dipeptides containing ␤-alanine by the brain-associated enzyme [2,6,11]. The brain enzyme was able to synthesize carcinine (NBAHA; Fig.…”