Effect of histamine antagonists on myocardial carcinine metabolism during compound -induced shock

Fitzpatrick, John; Fisher, Hans; Flancbaum, Louis

doi:10.1016/0022-4804(90)90023-u

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…Studies with radiolabeled histidine have demonstrated a metabolic link between carnosine, carcinine (β‐alanyl‐histamine) and histamine (Flancbaum et al , 1990a). Carnosine is present in many histamine‐rich tissues where, it has been suggested, it serves as a non‐mast cell source of histamine ( via histidine) during physiological ‘shock’ (Fitzpatrick et al , 1990). The view of carnosine as a functionally inert precursor for histamine may have to be re‐assessed in light of the present findings.…”

Section: Discussionmentioning

confidence: 99%

Analysis of an H₁ receptor‐mediated, zinc‐potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein

O'Dowd

Miller

1998

British J Pharmacology

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1 The contractile action of the dipeptide carnosine (b-alanyl-L-histidine), active as a Zn·carnosine complex (Zn·Carn), was investigated in isolated rings of rabbit saphenous vein (RSV) and was found to be antagonized by the H 1 antagonist mepyramine. 2 Mepyramine-sensitive, histamine-induced contractures in RSV, were smaller (73+0.1%) and less well sustained than carnosine-induced contractures. In the radioligand binding assay, the e ect of carnosine can be described as a function of Zn·Carn concentration with an apparent logIC 50 of 75.61. This value is consistent with that obtained from the functional studies on RSV. 7 Histamine-induced contractures have an indomethacine-sensitive component (27.2+8.3% of control response), not apparent with carnosine-induced contractures. 8 Like histamine, carnosine evoked an H 2 -mediated (cimetidine-sensitive) relaxation in the presence of mepyramine, but was less potent (10.8+3.1% residual tension at 10 mM carnosine compared with 13.4+7.5% at 0.1 mM histamine). 9 Carnosine, like mepyramine, can`reveal' the H 2 -mediated relaxation of histamine providing further evidence that carnosine binds at the H 1 receptor. 10 We conclude that carnosine can act at the smooth muscle H 1 -receptor to provoke vasoconstriction and that it also has the potential to act at H 1 -receptors in CNS.

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Section: Discussionmentioning

confidence: 99%

Analysis of an H₁ receptor‐mediated, zinc‐potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein

O'Dowd

Miller

1998

British J Pharmacology

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Carnosine: Its properties, functions and potential therapeutic applications

Quinn

Boldyrev

Formazuyk

1992

Molecular Aspects of Medicine

282

185

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Hemodynamic effects of carcinine in the anesthetized, instrumented, open-chest rat

Steinberg

Notterman

1996

Critical Care Medicine

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In this open-chest rat model, the primary pharmacologic effect of carcinine is systemic arterial vasodilation. A negative inotropic effect is suggested. Hypotension is secondary to these carcinine-induced actions. These results differ from results previously published using an isolated guinea pig heart preparation. Our model suggests that efforts to develop a clinical role for carcinine should exploit vascular rather than cardiac effects. Species differences may also play a role.

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Effect of histamine antagonists on myocardial carcinine metabolism during compound -induced shock

Cited by 4 publications

References 26 publications

Analysis of an H₁ receptor‐mediated, zinc‐potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein

Analysis of an H₁ receptor‐mediated, zinc‐potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein

Carnosine: Its properties, functions and potential therapeutic applications

Hemodynamic effects of carcinine in the anesthetized, instrumented, open-chest rat

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Effect of histamine antagonists on myocardial carcinine metabolism during compound -induced shock

Cited by 4 publications

References 26 publications

Analysis of an H1 receptor‐mediated, zinc‐potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein

Analysis of an H1 receptor‐mediated, zinc‐potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein

Carnosine: Its properties, functions and potential therapeutic applications

Hemodynamic effects of carcinine in the anesthetized, instrumented, open-chest rat

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Analysis of an H₁ receptor‐mediated, zinc‐potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein

Analysis of an H₁ receptor‐mediated, zinc‐potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein