Beta and Higher Homologous Amino Acids

Synthesis of a Chiral β-Amino Acid Derivative by a Cobalt-Catalysed Coupling Reaction

“…IR spectra were determined on a Bruker Vertex 70 spectrophotometer. 1 H NMR spectra were recorded using an Avance 400 MHz spectrometer. ESI-MS were recorded on a Dionex MSO-Plus Mass Spectrometer.…”

“…The synthesis of chiral β-amino acids and derivatives has attracted attention due to their importance in biologically active peptides and small molecule pharmaceuticals. 1 Much effort has been put into developing satisfactory synthetic routes for the preparation of β-amino acids and derivatives. Many methods have been reported, such as catalytic asymmetric hydrogenation of enamino derivatives, 2 Arndt-Eistert homologation of the α-amino acids, 3 asymmetric Michael addition of the chiral amino-group to α, β-unsaturated esters, 4 β-lactams ring opening 5,6 and others.…”

Synthesis of β-amino acids using Boc-/Z-amino acid pentafluorophenyl esters

“…fl-Amino acids are important natural products present in several peptides [1] as well as useful chiral units in the synthesis of fl-lactam antibiotics [2,3]. Recently Seebach and Matthews [4] and Gellman [5] et al, illustrated the structural similarities of acyclic and cyclic fl-and o~-peptides.…”

Tert-butyl esters of 2,3-diaryl-3-arylaminopropanoic acids - stereoselective synthesis, isolation, spectroscopic and structural elucidation

“…The design of novel substituted ß-amino acid derivatives is still interesting for organic chemistry due to their biologically important properties and the occurrence in natural products [1][2][3] . The stereoselective synthesis and optimization of the synthetic pathway for the obtaining of the pure diastereoisomers in good yields is an important key for the preparation of these compounds which are useful as building blocks for ß-lactams [4][5][6][7][8] and peptides, containing ß-amino acids 4,6 .…”