l-Ornithine affects peripheral clock gene expression in mice

Fukuda, Toshio; Haraguchi, Atsushi; Kuwahara, Mari; Nakamura, Kaai; Hamaguchi, Yutaro; Ikeda, Yuko; Ishida, Yuko; Wang, Guanying; Shirakawa, Chise; Tanihata, Yoko; Ohara, Kazuaki; Shibata, Shigenobu

doi:10.1038/srep34665

Cited by 17 publications

(8 citation statements)

References 34 publications

(50 reference statements)

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“…( 45 ) In addition, certain nutrients increase Per2 expression through the insulin secretion. ( 33 , 34 ) Taken together findings in this study and these previous reports suggest that CLPr acts as a clock-regulator to prevent and/or ameliorate metabolic disorders when administration of it at the suitable timing.…”

Section: Discussionsupporting

confidence: 85%

“…( 32 ) Recently, it has been reported that functional food ameliorates metabolic syndrome associating with circadian clock. ( 33 , 34 ) With regard to CLPr, it prevents obesity and hyperglycemia. ( 26 , 27 ) In this study, we found that CLPr regulated the circadian clock gene expression through GLP-1 signaling pathway in the liver using a GLP-1 receptor antagonist Exendin (9-39) (Fig.…”

Section: Discussionmentioning

confidence: 99%

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Cacao polyphenols regulate the circadian clock gene expression and through glucagon-like peptide-1 secretion

Hironao

Mitsuhashi

Huang

et al. 2020

J. Clin. Biochem. Nutr.

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Energy metabolism and circadian rhythms are closely related together, i.e., the timing of nutrient intake affects metabolism under the regulation of circadian rhythms. Previously, we have reported that cacao liquor procyanidin (CLPr) promotes energy metabolism, resulting in preventing obesity and hyperglycemia. However, it is not unclear whether CLPr regulates clock gene expression. In this study, we investigated whether the administration timing of CLPr affected clock gene expression and found that CLPr regulated the circadian clock gene expression through the glucagon-like peptide-1 (GLP-1) signaling pathway. CLPr administration at Zeitgeber time 3 increased the expression level of Per family and Dbp in the liver. At the same administration timing, CLPr increased GLP-1 and insulin concentration in the plasma and phosphorylation of AMPK in the liver. It was noteworthy that an antagonist for GLP-1 receptor Exendin (9-39) canceled CLPr-increased expression of Per family and Dbp and phosphorylation of AMPK in the liver, in addition to insulin secretion. These results strongly suggest that CLPr-induced GLP-1 regulates the changes in clock gene expression in the liver through increased insulin. Thus, CLPr is a possible functional food material for prevention and/or amelioration of metabolic disorders through preventing circadian disruption through GLP-1 and AMPK pathways.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Cacao polyphenols regulate the circadian clock gene expression and through glucagon-like peptide-1 secretion

Hironao

Mitsuhashi

Huang

et al. 2020

J. Clin. Biochem. Nutr.

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“…Recently, it was also reported that l-ornithine administration caused a phase advance of peripheral clocks via an increase in insulin secretion ( Fukuda et al, 2016 ); however the actual amino acid responsible for the strong entrainment of peripheral circadian rhythm remained unclear. Accordingly, we analyzed whether the administration of single amino acids affects the liver circadian rhythm through in vivo monitoring.…”

Section: Discussionmentioning

confidence: 99%

Glucagon and/or IGF-1 Production Regulates Resetting of the Liver Circadian Clock in Response to a Protein or Amino Acid-only Diet

et al. 2018

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The circadian system controls the behavior and multiple physiological functions. In mammals, the suprachiasmatic nucleus (SCN) acts as the master pacemaker and regulates the circadian clocks of peripheral tissues. The SCN receives information regarding the light-dark cycle and is thus synchronized to the external 24-hour environment. In contrast, peripheral clocks, such as the liver clock, receive information from the SCN and other factors; in particular, food intake which leads to insulin secretion induces strong entrainment of the liver clock. On the other hand, the liver clock of insulin-depleted mice treated with streptozotocin (STZ) has been shown to be entrained by scheduled feeding, suggesting that insulin is not necessary for entrainment of the liver clock by feeding. In this study, we aimed to elucidate additional mechanism on entraining liver clock by feeding a protein-only diet and/or amino-acid administration which does not increase insulin levels. We demonstrated that protein-only diet and cysteine administration elicit entrainment of the liver clock via glucagon secretion and/or insulin-like growth factors (IGF-1) production. Our findings suggest that glucagon and/or IGF-1 production are additional key factors in food-induced entrainment.

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“…The gene expression rhythm in several digestive organs is also affected by diet‐derived components such as lipids, amino acids and other nutrients (Dilixiati, Koyanagi, Kusunose, Matsunaga, & Ohdo, 2017; Fukuda et al, 2016; Furutani et al, 2015; Okamura et al, 2014). On the other hand, some diet‐derived compounds (fatty acids, vitamins, glucose) promote phosphorylation of CREB after activation of PKA or ERK (Cañón, Cosgaya, Scsucova, & Aranda, 2004; Costes et al, 2006; Lim et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches

et al. 2020

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The expression levels of many cell‐surface proteins vary with the time of day. Glycoprotein 2 (Gp2), specifically expressed on the apical surface of M cells in Peyer's patches, functions as a transcytotic receptor for mucosal antigens. We report that cAMP response element‐binding protein (CREB) regulates the transcription of the Gp2 gene, thereby generating the circadian change in its expression in mouse Peyer's patches. The transcytotic receptor activity of Gp2 was increased during the dark phase when the Gp2 protein abundance increased. Rhythmic expression of clock gene mRNA was observed in mouse Peyer's patches, and expression levels of Gp2 mRNA also exhibited circadian oscillation, with peak levels during the early dark phase. The promoter region of the mouse Gp2 gene contains several cAMP response elements (CREs). Chromatin immunoprecipitation assays revealed that CREB bound to the CREs in the Gp2 gene in Peyer's patches. Forskolin, which promotes CREB phosphorylation, increased the transcription of the Gp2 gene in Peyer's patches. As phosphorylation of CREB protein was increased when Gp2 gene transcription was activated, CREB may regulate the rhythmic expression of Gp2 mRNA in Peyer's patches. These findings suggest that intestinal immunity is controlled by the circadian clock system.

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l-Ornithine affects peripheral clock gene expression in mice

Cited by 17 publications

References 34 publications

Cacao polyphenols regulate the circadian clock gene expression and through glucagon-like peptide-1 secretion

Cacao polyphenols regulate the circadian clock gene expression and through glucagon-like peptide-1 secretion

Glucagon and/or IGF-1 Production Regulates Resetting of the Liver Circadian Clock in Response to a Protein or Amino Acid-only Diet

Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches

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