Cacao polyphenols regulate the circadian clock gene expression and through glucagon-like peptide-1 secretion

Hironao, Ken-Yu; Mitsuhashi, Yuji; Huang, Shujiao; Oike, Hideaki; Ashida, Hitoshi; Yamashita, Yoko

doi:10.3164/jcbn.20-38

Cited by 10 publications

(6 citation statements)

References 46 publications

(62 reference statements)

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“…Recently, we have demonstrated that a single oral administration of CLPr at ZT3 also increased phosphorylation of AMPK and LKB1 in the liver accompanied by increased plasma insulin and glucagon like peptide-1 (GLP-1). ( 18 ) In the same previous report, we found GLP-1 antagonist Exendin (9-39) canceled AMPK phosphorylation. Furthermore, it is reported that secretion of GLP-1 has the rhythm and its secretion level in the active-phase is higher than that in the rest-phase.…”

Section: Discussionsupporting

confidence: 70%

“…(17) Moreover, the results from our more recent report demonstrate that an antagonist for GLP-1 receptor Exendin (9-39) cancels CLPr-promoted AMPK phosphorylation. (18) In the same report, we have found that CLPr regulates the circadian clock gene expression through the GLP-1 signaling pathway. It is reported that AMPK down-regulates expression of Bmal1, which is one of the core clock genes.…”

mentioning

confidence: 78%

“…It is reported that AMPK down-regulates expression of Bmal1, which is one of the core clock genes. (18) These results suggest that anti-hyperglycemic effect of CLPr is associate with circadian rhythm. It is poorly understood that the effects of timing of polyphenol ingestion on the preventing postprandial hyperglycemia.…”

mentioning

confidence: 82%

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The cacao procyanidin extract-caused anti-hyperglycemic effect was changed by the administration timings

Hironao

Ashida

Yamashita

2020

J. Clin. Biochem. Nutr.

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Mammals have the biological clocks with approximately 24 h-rhythm. Energy metabolism including glucose metabolism is regulated by the biological clocks. Glucose metabolism is affected by not only meal volume and its energy but also meal timing. We have reported that cacao liquor procyanidin-rich extract (CLPr) ameliorated the postprandial hyperglycemia through AMP-activated protein kinase pathway. However, the effect of administration timing of CLPr on the postprandial hyperglycemia and its signaling pathway are still unclear. In the present study, we compared the effect of CLPr-administration at the rest-phase (light-period) and active-phase (dark-period) on glucose metabolism. Single oral administration of CLPr to ICR mice at the rest-phase, but not at the active-phase, promoted phosphorylation of AMP-activated protein kinase and its upstream liver kinase B1 and translocation of glucose transporter 4 to the plasma membrane in the skeletal muscle, resulting in reduced postprandial hyperglycemia. These results indicated that the intake of CLPr at the rest-phase more effectively suppressed postprandial hyperglycemia.

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Section: Discussionsupporting

confidence: 70%

mentioning

confidence: 78%

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The cacao procyanidin extract-caused anti-hyperglycemic effect was changed by the administration timings

Hironao

Ashida

Yamashita

2020

J. Clin. Biochem. Nutr.

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“…Skipping breakfast and eating late at night can result in a shift of the circadian clock to nighttime, increasing the risk of obesity and diabetes ( 7 ). Various functional food components have been reported to contribute to the regulation of the circadian clock, for instance, caffeine ( 8 ), and flavonoids ( 9 , 10 ). Functional food components can contribute to the regulation of the circadian clock and are thought to have beneficial effects on health from a chrono-nutritional perspective.…”

Section: Introductionmentioning

confidence: 99%

Euglena gracilis-derived β-glucan paramylon entrains the peripheral circadian clocks in mice

et al. 2023

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Paramylon, a β-1,3-glucan storage polysaccharide derived from Euglena gracilis, has various health benefits, such as anti-obesity effects and modulation of immune function. However, whether paramylon intake affects the circadian clock remains unknown. In this study, we examined the effect of paramylon intake on the circadian clock. The results showed that the paramylon intake regulated peripheral clocks in mice. Furthermore, cecal pH and short-chain fatty acid concentrations after paramylon intake were measured. The correlation between changes in the expression of clock-related genes and alterations in the intestinal environment was confirmed. In addition, peripheral clock entrainment by paramylon intake was not observed in antibiotic-treated mice whose gut microbiota was weakened. These findings suggest that the regulation of the circadian clock by paramylon intake was mediated by changes in gut microbiota. In addition, the entraining effect of paramylon intake was also confirmed in mice bred under conditions mimicking social jetlag, which implies that paramylon intake may contribute to recovery from social jetlag. Thus, the appropriate consumption of paramylon may have a beneficial effect on health from a chrono-nutritional perspective.

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“…In this sense, the daily light/dark cycle represents circadian rhythms’ primary synchronizer (‘zeitgeber’) [ 4 ]. However, certain nutrients have been reported to act as non-photic zeitgebers, such as caffeine [ 5 ] and dietary polyphenols [ 6 ]. The present review aims at providing evidence on the molecular bases of the role of dietary omega-3 (ω-3) fatty acids as non-photic zeitgebers.…”

Section: Introductionmentioning

confidence: 99%

Role of Omega-3 Fatty Acids as Non-Photic Zeitgebers and Circadian Clock Synchronizers

Checa-Ros

D’Marco

2022

IJMS

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Omega-3 fatty acids (ω-3 FAs) are well-known for their actions on immune/inflammatory and neurological pathways, functions that are also under circadian clock regulation. The daily photoperiod represents the primary circadian synchronizer (‘zeitgeber’), although diverse studies have pointed towards an influence of dietary FAs on the biological clock. A comprehensive literature review was conducted following predefined selection criteria with the aim of updating the evidence on the molecular mechanisms behind circadian rhythm regulation by ω-3 FAs. We collected preclinical and clinical studies, systematic reviews, and metanalyses focused on the effect of ω-3 FAs on circadian rhythms. Twenty animal (conducted on rodents and piglets) and human trials and one observational study providing evidence on the regulation of neurological, inflammatory/immune, metabolic, reproductive, cardiovascular, and biochemical processes by ω-3 FAs via clock genes were discussed. The evidence suggests that ω-3 FAs may serve as non-photic zeitgebers and prove therapeutically beneficial for circadian disruption-related pathologies. Future work should focus on the role of clock genes as a target for the therapeutic use of ω-3 FAs in inflammatory and neurological disorders, as well as on the bidirectional association between the molecular clock and ω-3 FAs.

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Cacao polyphenols regulate the circadian clock gene expression and through glucagon-like peptide-1 secretion

Cited by 10 publications

References 46 publications

The cacao procyanidin extract-caused anti-hyperglycemic effect was changed by the administration timings

The cacao procyanidin extract-caused anti-hyperglycemic effect was changed by the administration timings

Euglena gracilis-derived β-glucan paramylon entrains the peripheral circadian clocks in mice

Role of Omega-3 Fatty Acids as Non-Photic Zeitgebers and Circadian Clock Synchronizers

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