L-glutamine and L-glutamate in diets with different lactose levels for piglets weaned at 21 days of age

Molino, Juliano Pelição; Donzele, Juarez Lopes; Oliveira, Rita Flávia Miranda de; Saraiva, Alysson; Haese, Douglas; Fortes, Eduardo Ianino; Souza, Matheus Faria de

doi:10.1590/s1516-35982012000100015

Cited by 16 publications

(21 citation statements)

References 18 publications

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“…It is known that small intestine is the site where most nutrients are digested and absorbed (Rivest et al 2000) and colon and caecum are less important (Rudolph et al 1983). Thus sodium butyrate affecting intestine development may also improve nutrient absorption, especially in jejunum (Kotunia et al 2004;Molino et al 2012), and in consequence piglet performance.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary glutamine, glucose and/or sodium butyrate on piglet growth, intestinal environment, subsequent fattener performance, and meat quality

Hańczakowska

Niwińska

Grela³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:The effect of feed supplementing with glutamine, glucose and/or sodium butyrate was estimated on 156 piglets. The after-effect of supplements on fattener performance, carcass traits, and meat quality was examined. Piglets were allocated to 5 groups and fed standard feed mixture alone (control -C) or supplemented with 10 g of l-glutamine, or 10 g of glucose, or 3 g of sodium butyrate per kg of diet or all of these compounds (groups GT, GC, SB, and GT+GC+SB, respectively). Six piglets from each group were slaughtered at 63 days of age, their intestines were prepared and their parts measured. Digesta from ileum and caecum was taken for analysis. Its acidity and volatile fatty acids content were evaluated. Morphological structure of duodenal and ileal epithelium was estimated. After 84 days of age 20 animals from each group were fed the standard mixture. After 100 days of fattening 8 pigs from each group were slaughtered, pH of meat was measured, and samples of the longissimus muscle were taken for analysis. Body weight gains of piglets fed diets supplemented with SB or all supplements were higher than those of controls. All supplements given together increased total intestinal weight and length. Epithelial villi in jejunum were the highest in piglets receiving all supplements. Their height in the duodenum ranged from 296 to 347 µm and in the jejunum they were higher: 336 -424 μm. After 100 days of fattening body weight of all experimental animals was higher than that of control. There was no significant difference in carcass and meat quality. Sodium butyrate added to the diet improved piglet performance probably due to changes in intestine development and in intestinal epithelium structure. This positive effect was enhanced to some extent by the addition of glutamine or glucose.

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Section: Discussionmentioning

confidence: 99%

Effect of dietary glutamine, glucose and/or sodium butyrate on piglet growth, intestinal environment, subsequent fattener performance, and meat quality

Hańczakowska

Niwińska

Grela³

et al. 2014

CZECH J ANIM SCI

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“…Numerous studies have suggested that glutamine has positive effects on piglet growth performance, intestinal morphology, epithelial cell renewal, antioxidant capacity and barrier functions (Wu et al, 1996;Domeneghini et al, 2006;Wang et al, 2008 and2014;Molino et al, 2012;Zhu et al, 2015;Jiang et al, 2017).…”

Section: Glutamine Regulates Intestinal Function Of Weaning Pigsmentioning

confidence: 99%

Review: The roles and functions of glutamine on intestinal health and performance of weaning pigs

Wang

Yang

et al. 2019

Animal

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The gut is composed of a single layer of intestinal epithelial cells and plays important roles in the digestion and absorption of nutrients, immune and barrier functions and amino acid metabolism. Weaning stress impairs piglet intestinal epithelium structural and functional integrities, which results in reduced feed intake, growth rates and increased morbidity and mortality. Several measures are needed to maintain swine gut development and growth performance after weaning stress. A large body of evidence indicates that, in weaning piglets, glutamine, a functional amino acid, may improve growth performance and intestinal morphology, reduce oxidative damage, stimulate enterocyte proliferation, modulate cell survival and death and enhance intestinal paracellular permeability. This review focuses on the effects of glutamine on intestinal health in piglets. The aim is to provide evidentiary support for using glutamine as a feed additive to alleviate weaning stress.

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“…However, results differ regarding the effects of glutamine on intestinal villi height and crypt depth. Some authors verified that glutamine only influences villi height in swine (MOLINO et al, 2012), Nile tilapia juvenile (SILVA et al, 2010) and broilers (BARTELL & BATAL, 2007). Other authors verified that glutamine influences crypt depth (MAIORKA et al, 2000).…”

Section: Resultsmentioning

confidence: 97%

“…The localization of box inside conventional shed was adopted as blocks criteria. Corn and soybean meal diets were formulated to meet broiler requirements (ROSTAGNO et al, 2005) for all nutrients and no anticoccidial agents and antibiotics were used as growth promoters (Table 1). The feeding program adopted had four phases as follows: pre-starter (1 to 7 days old); starter (8 to 21 days old), growth (22 to 35 days old) and finishing phase (36 to 42 days old).…”

Section: Methodsmentioning

confidence: 99%

Performance and intestinal characteristics of broiler chicken fed diet with glutamine in the diet without anticoccidials agents

Nascimento

Leandro

Café

et al. 2014

Rev. bras. saúde prod. anim.

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SUMMARYFive hundred commercial male Cobb broilers were allotted in a randomized blocks design with five treatments, four replicates and 25 chicks per experimental unit in order to evaluate the effects of adding L-glutamine to the diet with no anticoccidial agents and growth promoters. Experimental diets contained L-glutamine at different levels (0.0; 5.0; 10.0; 15.0 or 20.0g/kg), through the experimental period. Experiment was conducted with broiler chicken from 1 to 42 days old. The parameters evaluated were feed intake, feed conversion ratio, body weight gain, mortality, digestibility coefficients of dry matter, crude protein and ether extract, carcass yield and intestinal mucosa structure of small intestine. The data obtained were submitted to polynomial regression analysis. Means were compared using Tukey test.Was considered a type I error set at P ≤ 0.05. The level of L-glutamine in the diet influenced feed conversion ratio of broilers at 1-7 days old, which was improved at 10.0g/kgL glutamine. Carcass yield and digestibility coefficients of the diet were not affected by the levels of glutamine in the diet. Adding L-glutamine influenced crypt depth in small intestine of broilers at 18 and 42 days old. It is recommended the addition of 10.0g/kg L-glutamine to the pre-started diet.

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L-glutamine and L-glutamate in diets with different lactose levels for piglets weaned at 21 days of age

Cited by 16 publications

References 18 publications

Effect of dietary glutamine, glucose and/or sodium butyrate on piglet growth, intestinal environment, subsequent fattener performance, and meat quality

Effect of dietary glutamine, glucose and/or sodium butyrate on piglet growth, intestinal environment, subsequent fattener performance, and meat quality

Review: The roles and functions of glutamine on intestinal health and performance of weaning pigs

Performance and intestinal characteristics of broiler chicken fed diet with glutamine in the diet without anticoccidials agents

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