Kyasanur Forest Disease: a Status Update

John, Jeny K.

doi:10.14737/journal.aavs/2014/2.6.329.336

Cited by 11 publications

(16 citation statements)

References 40 publications

(74 reference statements)

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“…Dehydration may be aggravated due to poor intake of fluids. Other non-specific features such as lymphadenopathy and hepato-splenomegaly are also reported 1 2 4 12 13 14 15 . Convalescence period is prolonged.…”

Section: Clinical Profile Of Kyasanur Forest Disease (Kfd)mentioning

confidence: 97%

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Clinical & epidemiological significance of Kyasanur forest disease

Munivenkatappa

Sahay²,

Yadav³

et al. 2018

Indian J Med Res

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Kyasanur forest disease (KFD) is a known viral haemorrhagic fever in India, for the last 60 years. However, in recent years, the change in epidemiological profile of the disease has suggested that it is now time to consider KFD as an emerging tropical disease in India. The preference should be to educate not only the villagers where it is being reported or detected but also to public health experts, veterinarians, forest officials and medical professionals to pay attention while seeing a patient overlapping with endemic diseases such as Japanese encephalitis, West Nile, dengue, chikungunya, malaria and tuberculosis. Although the existence of KFD is known for a long time, updated understanding of its clinical profile in humans is still limited. This article describes in detail the clinical presentation of KFD reported till date. It also highlights geographical distribution of the disease, risk factors for virus transmission, biochemical/haematological findings and control measures. There is an urgent need for research on KFD, particularly for understanding biphasic nature of illness, development of cost-effective diagnostic tools, utility of non-invasive samples for diagnosis and development of new vaccines.

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Section: Clinical Profile Of Kyasanur Forest Disease (Kfd)mentioning

confidence: 97%

“…In general, most patients recover in 10-14 days. During the recovery phase, patients may present with muscle twitching, coarse tremors, paraesthesia and generalized shaking due to weakness 1 2 3 4 12 13 14 15 .…”

Section: Clinical Profile Of Kyasanur Forest Disease (Kfd)mentioning

confidence: 99%

Clinical & epidemiological significance of Kyasanur forest disease

Munivenkatappa

Sahay²,

Yadav³

et al. 2018

Indian J Med Res

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“…Ebola and Zika virus outbreak in 2014 [49] and 2015 [50] respectively posed a serious problem to world. Kyasanur forest disease virus (KFDV) in India has been outbreak time to time, caused hemorrhagic fever and neurological disturbances [51]. In our study, we have predicted eight mature miRNAs in KFDV genome and their target genes in human.…”

Section: Resultsmentioning

confidence: 99%

Genome Wide Computational Prediction of miRNAs in Kyasanur Forest Disease Virus and their Targeted Genes in Human

Saini¹,

Thakur²,

Kumar³

2016

Preprint

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RNAs are versatile biomolecules and can be coding or non-coding. Among the non-coding RNAs, miRNAs are small endogenous molecules that play important role in posttranscriptional gene regulation. miRNAs are identified in viruses too and involved in down regulation of host genes. Flavivirus family members are classified in to two groups: mosquito-borne flaviviruses (MBFV) and tick-borne flaviviruses (TBFV). Kyasanur forest disease virus (KFDV) found in India in 1957 (Karnataka) relates to TBFV. Virus has been diffuse to new areas in India and needs attention as it can cause severe hemorrhagic fever. Here in this study, we scanned the virus genome for prediction of miRNAs that can inhibit host target genes. VMir, tool was used for extraction of pre-miRNAs. A total of four miRNAs were found and submitted to ViralMir for classification in to real or pseudo. Interestingly, all four pre-miRNAs were classified as real.Eight mature miRNAs were located in pre-miRNAs by Mature Bayes. A total of 539 human target genes has been identified by using miRDB but ANGPT1 (angiopoietin 1) and TFRC (transferrin receptor) genes were screened to play role in hemorrhagic fever and neurological problems. GO analysis of target genes also supported the evidences.

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“…Kyasanur Forest disease virus reappeared in Wayanad in the year 2014 where as an outbreak occurred in Nilambur of Malappuram district in the month of June (Murhekar et al., ; Tandale, Balakrishnan, Yadav, Marja, & Mourya, ). In the same year, KFD has been diagnosed among monkeys residing in a temple compound at Vallikkavu near Chengannur in Alappuzha district of Kerala (John et al., ; The Pioneer, ). During January to May 2015, an outbreak was reported from the villages near Pulpally in the Wayanad Wildlife Sanctuary causing many monkey deaths and 18 confirmed human cases out of which seven from Pulpally, eight from Mullankolly and other three cases from Chethayalayam and Poothadi.…”

Section: Emergence Of Kfdv Adding New Territories During 2012–2016mentioning

confidence: 99%

Kyasanur forest disease virus breaking the endemic barrier: An investigation into ecological effects on disease emergence and future outlook

Ajesh

Nagaraja²,

Sreejith

2017

Zoonoses and Public Health

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Kyasanur Forest disease (KFD) is found in a limited range of India, but is epidemiologically understudied. The seasonal patterns of KFD are well known; however, the significant concern is on the extent to which changes in epidemiology happen especially under the influence of ecological destructions and by the eventual effects of resulting climate change. Presently, a southward and northward spread of the Kyasanur Forest disease virus (KFDV) along the Western Ghats has been reported in the adjoining states of Kerala, Tamil Nadu, Goa and Maharashtra. In this review, we investigate the cascade of factors that might have facilitated the resurgence of KFDV among the endemic regions in higher frequency and its recent emergence in the area previously not reported. Utilizing published data, we additionally endeavour to exhibit a portion of the impediments of control systems and embody the powerful option strategies for developing KFDV control.

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Kyasanur Forest Disease: a Status Update

Cited by 11 publications

References 40 publications

Clinical & epidemiological significance of Kyasanur forest disease

Clinical & epidemiological significance of Kyasanur forest disease

Genome Wide Computational Prediction of miRNAs in Kyasanur Forest Disease Virus and their Targeted Genes in Human

Kyasanur forest disease virus breaking the endemic barrier: An investigation into ecological effects on disease emergence and future outlook

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