Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Bang, Hyangju; Kwak, Jung Hyun; Ahn, Hyeon Yeong; Shin, Dong Yeob; Lee, Jong Ho

doi:10.1089/jmf.2013.2889

Cited by 60 publications

(56 citation statements)

References 15 publications

(17 reference statements)

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“…Subjects were randomized in a double-blind, placebo-controlled trial. The trial results showed that 12 weeks of intervention with KRG supplementation (5 g/ day) led to normalization of whole blood and serum glucose levels as well as serum insulin and CRP concentrations (Bang et al, 2014). Administration of Panax Ginseng extract (PGE) for 8 weeks (6 g/day) decreased serum triglycerides and total cholesterol and LDL levels, while increasing HDL levels.…”

Section: Ginseng To the Clinicmentioning

confidence: 99%

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an alternative treatment approach for several diseases including CVDs. Currently, there is an unprecedented drive for the use of herbal preparations in modern medicinal systems. This drive is powered by several aspects, prime among which are their cost-effective therapeutic promise compared to standard modern therapies and the general belief that they are safe. Nonetheless, the claimed safety of herbal preparations yet remains to be properly tested. Consequently, public awareness should be raised regarding medicinal herbs safety, toxicity, potentially lifethreatening adverse effects, and possible herb-drug interactions. Over the years, laboratory data have shown that medicinal herbs may have therapeutic value in CVDs as they can interfere with several CVD risk factors. Accordingly, there have been many attempts to move studies on medicinal herbs from the bench to the bedside, in order to effectively employ herbs in CVD treatments. In this review, we introduce CVDs and their risk factors. Then we overview the use of herbs for disease treatment in general and CVDs in particular. Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Ginseng, Ginkgo biloba, Ganoderma lucidum, and Gynostemma pentaphyllum, are gathered and reviewed. In particular, the employment of these four plants in the context of CVDs, such as myocardial infarction, hypertension, peripheral vascular diseases, coronary heart disease, cardiomyopathies, and dyslipidemias has been reviewed, analyzed, and critically discussed. We also endeavor to document the recent studies aimed to dissect the cellular and molecular cardio-protective mechanisms of the four plants, using recently reported in vitro and in vivo studies. Finally, we reviewed and reported the results of the

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Section: Ginseng To the Clinicmentioning

confidence: 99%

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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“…Our previous study indicated that KRG supplementation was efficacious for glucose control [12]. Therefore, we applied a similar study design for this randomized, double-blind, and placebo-controlled clinical trial to evaluate the effect of AF supplementation on blood glucose control in subjects with IFG, IGT, or newly diagnosed type 2 diabetes mellitus (T2DM).…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic effect of short-term arginyl-fructose supplementation in subjects with prediabetes and newly diagnosed type 2 diabetes: randomized, double-blinded, placebo-controlled trial

Park

Kim

Kwak

et al. 2015

Trials

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BackgroundA previous study reported that arginyl-fructose may have great value as a functional food with antioxidant and antidiabetic activities. However, there have been few clinical studies on the efficacy of arginyl-fructose supplementation for blood glucose control.MethodsIn this double-blind, placebo-controlled study, 60 Korean subjects with prediabetes or type 2 diabetes mellitus were randomly assigned to placebo or test groups. The test group subjects received 1500 mg/day arginyl-fructose. Fasting serum levels of glucose, hemoglobin A1c, insulin, and free fatty acids were measured by 2-hour oral glucose tolerance tests at baseline and after the 6-week intervention. Eleven subjects dropped out or were excluded during the trial. The data for the remaining 49 were statistically analyzed using Student’s t-test and paired t-test.ResultsAfter the 6-week intervention, the test group showed significant reductions in serum glucose levels at 30 minutes (−19.4 ± 5.62 mg/dL) and 60 minutes (−15.4 ± 7.01 mg/dL) and reduced glucose area under the curve (−27.4 ± 8.59 mg/dL) compared with those of the placebo control group. The changes (differences from baseline) in serum glucose levels at 60 minutes and glucose area under the curve in the test group differed significantly from those in the control group even after adjusting for baseline values. In contrast, glucose-related biomarkers including hemoglobin A1c, insulin, and C-peptide levels were not significantly improved by the dietary intervention with arginyl-fructose.ConclusionsArginyl-fructose supplementation (1500 mg/day) may be beneficial for reducing postprandial blood glucose levels in patients with prediabetes or type 2 diabetes mellitus.Trial registrationClinicalTrials.gov NCT02285231. Registered 11 May 2014.Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-015-1036-z) contains supplementary material, which is available to authorized users.

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“…produced through the fermentation process. As reported by Bang et al in the clinical trial [20], 5 g/day of Korean red ginseng can reduce fast blood glucose and glucose AUC. However, in this study [21], the fermented red ginseng only modulated postprandial glucose and insulin, not fasting glucose and insulin.…”

Section: Anti-diabetic Effects Of Ginseng In Human Trialsmentioning

confidence: 55%

“…Participants with impaired fasting glucose, impaired glucose tolerance, or type 2 diabetes consuming 5 g/day Korean red ginseng (KRG) extract were found to have significantly reduced blood glucose. Specifically, −1.23 ± 0.59 mmol/L of serum glucose and -0.97 ± 0.30 mmol/L of whole blood glucose were decreased at a 30 min oral glucose tolerance test after a 12-week intervention [20]. The plasma insulin sensitivity index increased by 33% compared to the placebo group in this 12-week randomized, double-blind and placebo-controlled trial [20].…”

Section: Anti-diabetic Effects Of Ginseng In Human Trialsmentioning

confidence: 78%

Review of Ginseng Anti-Diabetic Studies

2019

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Ginseng is one of the most valuable and commonly used Chinese medicines not only in ancient China but also worldwide. Ginsenosides, also known as saponins or triterpenoids, are thought to be responsible for the beneficial effects of ginseng. In this review, we summarize recent publications on anti-diabetic studies of ginseng extracts and ginsenosides in cells, animals, and humans. It seems that the anti-diabetic effect of ginseng is positive for type 2 diabetic patients but has no significant impact on prediabetes or healthy adults. Regulation of insulin secretion, glucose uptake, anti-oxidative stress, and anti-inflammatory pathways may be the mechanisms involved with ginseng’s anti-diabetic effects. Taken together, this summary provides evidence for the anti-diabetes effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their impact on diabetes.

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Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Cited by 60 publications

References 15 publications

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Antihyperglycemic effect of short-term arginyl-fructose supplementation in subjects with prediabetes and newly diagnosed type 2 diabetes: randomized, double-blinded, placebo-controlled trial

Review of Ginseng Anti-Diabetic Studies

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