Knowledge, Attitudes, and Perceived Barriers toward Genetic Testing and Pharmacogenomics among Healthcare Workers in the United Arab Emirates: A Cross-Sectional Study

Rahma, Azhar T.; Elsheik, Mahanna; Ali, Bassam R.; Elbarazi, Iffat; Patrinos, George P.; Ahmed, Luai A.; Al-Maskari, Fatma

doi:10.3390/jpm10040216

Cited by 20 publications

(23 citation statements)

References 76 publications

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“…These findings may reflect pharmacists curiosity especially young and under training towards the studied topic in comparison to physicians and other respondents. Our results were similar to previous studies conducted in UAE and Qatar, [ 23 , 24 ] yet distinct from those reported in a prior study in Kuwait [ 20 ], where most participants were males and physicians.…”

Section: Discussionsupporting

confidence: 89%

“…In our study, the influence of the profession was more significant in the knowledge of PGx in particular but not towards PGx testing awareness for which the experience had a larger impact. Furthermore, our findings demonstrated that younger age and less experienced professionals had the highest PGx knowledge, these results are in line with the study of Rahma et al [ 23 ] however they are inconsistent with the findings of some previous studies [ 20 , 24 ] where the influence of experience was dominant.…”

Section: Discussioncontrasting

confidence: 62%

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Pharmacogenetics: Knowledge assessment amongst Syrian pharmacists and physicians

Albitar

Alchamat

2021

BMC Health Serv Res

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Background Pharmacogenetics targets genetic variations that influence drug response. It is relatively a new science that has not been vastly employed in most developing countries including Syria. Therefore we aimed at evaluating the depth of knowledge in pharmacogenetics and the attitude towards it amongst Syrian pharmacists and physicians. Methods We carried out an internet-based questionnaire consisted of 26 questions, sent through specialized websites and private groups with a large number of pharmacists and physicians members. The survey was available online for a period of 1 month. Results The total number of respondents was 154, mostly female pharmacists. Our statistical analysis showed a strong positive association between profession (in favour of pharmacists) and pharmacogenetics knowledge p = 0.049; however, no correlation with experience p = 0.811 was found. A significant difference was reported between the knowledge of pharmacists and physicians p = 0.001 concerning drugs that need pharmacogenetics testing before being prescribed. The majority of respondents had no information about applying genetic tests in Syria before prescribing medications nor did they possess the knowledge regarding drugs that show differential responses in patients according to their unique genotypes. In our study, the percentage knowledge assessment score was low in general (mean ± Standard deviation, SD) (46% ± 13.9%). The majority of the respondents agreed that pharmacists should provide counselling to patients on the subject of pharmacogenetics. Respondents’ opinions varied concerning making pharmacogenetics learning a priority. Conclusion Lack of pharmacogenetics knowledge was found amongst respondents in general. Our findings raise concerns about the lack of awareness amongst physicians, which may hinder the implementation of this crucial field in Syria. We suggest an emphasis on the role of education, training, and conducting genotyping research on the Syrian population.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 62%

Pharmacogenetics: Knowledge assessment amongst Syrian pharmacists and physicians

Albitar

Alchamat

2021

BMC Health Serv Res

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“…Furthermore, many participants were unaware that Plavix ® (clopidogrel) PGx testing was available. A survey of healthcare workers in the Emirate found that their knowledge of PGx is fair, 41 which is similar to the findings of this study.…”

Section: Discussionsupporting

confidence: 88%

Physicians’ Knowledge and Attitudes Regarding Point-of-Care Pharmacogenetic Testing: A Hospital-Based Cross-Sectional Study

Muflih¹,

Alshogran²,

Al‐Azzam³

et al. 2021

PGPM

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Introduction Pharmacogenetic testing (PGx) is a diagnostic technique used by physicians to determine the possible reactions of patients to drug treatment on the basis of their genetic makeup. The aim of this study was to determine the impact of physicians’ awareness, attitudes, and sociodemographics on the adoption of point-of-care (POC) PGx testing as a diagnostic method, as well as the impact of their knowledge, attitudes, and sociodemographics on its adoption. Methods A cross-sectional survey of 200 physicians and medical trainees working at the Clinics of King Abdullah University Hospital in Jordan was performed. Data on sociodemographics, knowledge and attitudes concerning PGx testing, genetic information sources, and barriers to POC-PGx testing adoption were gathered. Results Participants’ perceived knowledge of the role of PGx testing in therapeutic decision-making was rated as “Excellent” (1.9%), “Very Good” (19.4%), “Good” (34.4%), “Fair” (32.5%), and “Poor” (11.9%). Physicians’ actual knowledge of PGx testing was adequate (mean=3.56 out of 7, SD=1.2), but their attitudes were generally favorable (mean=3.64 out of 5.00, SD=0.52). According to Rogers’ theory, many variables (eg, perceived need, relative advantage, compatibility) had a significant impact on physicians’ willingness to endorse POC-PGx testing. Discussion The majority of physicians stated that they were unaware of PGx testing. Physicians’ perceived knowledge of POC-PGx testing, however, was higher than those who participated in other studies. Participants were optimistic about the future benefits of PGx testing in prescribing effective medications and reducing potential side effects, which were consistent with previous studies. Physicians’ willingness to accept and implement POC-PGx testing was hampered by a lack of PGx expertise, as well as concerns about patient confidentiality, employability, and insurability. More training and genetic courses are needed, according to the majority of participants.

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“…Moreover, with pre-emptive testing, delays would not be an issue anymore. The other results concerning the risks are consistent with foreign studies among psychiatrists [ 26 , 30 ] and various health workers [ 44 ].…”

Section: Discussionsupporting

confidence: 88%

Acceptability of Pharmacogenetic Testing among French Psychiatrists, a National Survey

Laplace

Calvet

Lacroix

et al. 2021

JPM

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Psychiatric disorder management is based on the prescription of psychotropic drugs. Response to them remains often insufficient and varies from one patient to another. Pharmacogenetics explain part of this variability. Pharmacogenetic testing is likely to optimize the choice of treatment and thus improve patients’ care, even if concerns and limitations persist. This practice of personalized medicine is not very widespread in France. We conducted a national survey to evaluate the acceptability of this tool by psychiatrists and psychiatry residents in France, and to identify factors associated with acceptability and previous use. The analysis included 397 observations. The mean acceptability score was 10.70, on a scale from 4 to 16. Overall acceptability score was considered as low for 3.0% of responders, intermediate for 80.1% and high for 16.9%. After regression, the remaining factors influencing acceptability independently of the others were prescription and training history and theoretical approach. The attitude of our population seems to be rather favorable, however, obvious deficiencies have emerged regarding perceived skills and received training. Concerns about the cost and delays of tests results also emerged. According to our survey, one of the keys to overcoming the barriers encountered in the integration of pharmacogenetics seems to be the improvement of training and the provision of information to practitioners.

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Knowledge, Attitudes, and Perceived Barriers toward Genetic Testing and Pharmacogenomics among Healthcare Workers in the United Arab Emirates: A Cross-Sectional Study

Cited by 20 publications

References 76 publications

Pharmacogenetics: Knowledge assessment amongst Syrian pharmacists and physicians

Pharmacogenetics: Knowledge assessment amongst Syrian pharmacists and physicians

Physicians’ Knowledge and Attitudes Regarding Point-of-Care Pharmacogenetic Testing: A Hospital-Based Cross-Sectional Study

Acceptability of Pharmacogenetic Testing among French Psychiatrists, a National Survey

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