Knee stability after arthroscopic anterior cruciate ligament reconstruction using the middle third of the patellar ligament and quadrupled hamstring tendons grafts – A two-year follow-up

Zelić, Zoran; Vidaković, Ivan; Biuk, Egon; Biuk, Dubravka; Wertheimer, Vjekoslav; Kolarević, Vjekoslav

doi:10.1016/j.injury.2015.10.056

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…Autograft‐based surgical reconstruction is the major strategy to treat CL injury, where bone‐PT‐bone is one of the most popular option, thanks to its long‐term stability after surgical reconstruction . Our study explored the differential gene expression and cellular dynamics underlying CL, PT, and patella development during embryogenesis, which might provide indications on the graft choice for CL reconstruction from the developmental biology point of view.…”

Section: Discussionmentioning

confidence: 99%

“…Cruciate ligament (CL) is one of the most common ligaments that are present in the knee joint. It is critical for the biomechanical stability and function of the knee joint and its rupture is often associated with a higher susceptibility to meniscal injury and early onset of degenerative changes . Patellar tendon (PT) is the distal part of the quadriceps tendon that connects the patella to the tibia tuberosity.…”

Section: Introductionmentioning

confidence: 99%

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Cruciate ligament, patellar tendon, and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds

Zhang

Kameneva

Annusver

et al. 2020

Developmental Dynamics

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Background: Cruciate ligament (CL) and patellar tendon (PT) are important elements of the knee joint, uniting femur, patella, and tibia into a single functional unit. So far, knowledge on the developmental mechanism of CL, PT, and patella falls far behind other skeletal tissues.Results: Here, employing various lineage tracing strategies we investigate the cellular sources and dynamics that drive CL, PT, and patella formation during mouse embryonic development. We show that Gdf5 and Gli1 are generally expressed in the same cell population that only contributes to CL, but not PT or patella development. In addition, Col2 is expressed in two independent cell populations before and after joint cavitation, where the former contributes to the CL and the dorsal part of the PT and the latter contributes to the patella.Moreover, Prrx1 is always expressed in CL and PT progenitors, but not patella progenitors where it is switched off after joint cavitation. Finally, we reveal that patella development employs different cellular dynamics before and after joint cavitation.Conclusions: Our findings delineate the expression changes of several skeletogenesis-related genes before and after joint cavitation, and provide an indication on the cellular dynamics underlying ligament, tendon, and sesamoid bone formation during embryogenesis. K E Y W O R D S cellular dynamics, cruciate ligament, embryonic development, lineage tracing, patella, patellar tendon

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cruciate ligament, patellar tendon, and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds

Zhang

Kameneva

Annusver

et al. 2020

Developmental Dynamics

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“…TDPCs have a relatively high in vitro proliferation capacity, so only a small amount of autogenous tendon is required to generate clinically useful cell numbers . In human patients, healthy tendon autografts are routinely obtained from patellar tendon and palmaris longus tendon, for cruciate and ulnar collateral ligament reconstruction, respectively. These could also be used as sources for autogenous TDPC isolation.…”

Section: Discussionmentioning

confidence: 99%

Tendon‐derived progenitor cells improve healing of collagenase‐induced flexor tendinitis

Durgam

Stewart

Sivaguru

et al. 2016

Journal Orthopaedic Research

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Tendinitis is a common and a performance-limiting injury in athletes. This study describes the value of intralesional tendon-derived progenitor cell (TDPC) injections in equine flexor tendinitis. Collagenase-induced tendinitis was created in both front superficial digital flexor (SDF) tendons. Four weeks later, the forelimb tendon lesions were treated with 1 × 10 autogenous TDPCs or saline. Tendinitis was also induced by collagenase in one hind SDF tendon, to study the survival and distribution of DiI-labeled TDPCs 1, 2, 4, and 6 weeks after injection. The remaining normal tendon was used as a "control." Twelve weeks after forelimb TDPC injections, tendons were harvested for assessment of matrix gene expression, biochemical, biomechanical, and histological characteristics. DiI-labeled TDPCs were abundant 1 week after injection but gradually declined over time and were undetectable after 6 weeks. Twelve weeks after TDPC injection, collagens I and III, COMP and tenomodulin mRNA levels were similar (p = 0.3) in both TDPC and saline groups and higher (p < 0.05) than normal tendon. Yield and maximal stresses of the TDPC group were significantly greater (p = 0.005) than the saline group's and similar (p = 0.6) to normal tendon. However, the elastic modulus of the TDPC and saline groups were not significantly different (p = 0.32). Histological assessment of the repair tissues with Fourier transform-second harmonic generation imaging demonstrated that collagen alignment was significantly better (p = 0.02) in TDPC group than in the saline controls. In summary, treating collagenase-induced flexor tendon lesions with TDPCs improved the tensile strength and collagen fiber alignment of the repair tissue. Study Design © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:2162-2171, 2016.

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“…In our study, 84.3% of the ACL-injured patients in the database did not undergo reconstruction; these individuals might try alternative therapies for an ACL tear, such as rehabilitation prior to surgery. Indeed, ACL reconstruction is well recognized as a strategy to prevent knee joint instability, enabling these patients to return to an active lifestyle [31]. Reconstruction typically restores knee stability and ensures the successful return of function in the short term; however, the long-term consequences vary [32].…”

Section: Discussionmentioning

confidence: 99%

Association of anterior cruciate ligament injury with knee osteoarthritis and total knee replacement: A retrospective cohort study from the Taiwan National Health Insurance Database

et al. 2017

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ObjectiveThis study aimed to support the potential protective role of anterior cruciate ligament (ACL) reconstruction against the development of osteoarthritis (OA).MethodsIn this retrospective cohort study, the long-term results of ACL reconstruction in Taiwan were evaluated based on data from the National Health Insurance Research Database (NHIRD). In total, 8,769 eligible cases were included from 11,921 ACL-injured patients. The cumulative incidence rates of OA and total knee replacement (TKR) were analyzed using the Kaplan-Meier estimator. Cox proportional hazards models were applied to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of OA.ResultsThere was a lower cumulative incidence of OA among ACL-reconstructed patients (271, 33.1%) than among non-reconstructed patients (1,874, 40.3%; p < 0.001). Patients who underwent ACL reconstruction had a lower cumulative incidence of TKR during the follow-up period (0.6%) than the non-reconstructed patients (4.6%, p < 0.001). After adjusting for covariates, ACL-injured patients who underwent reconstruction within one month after ACL injury showed a significantly lower risk of OA than those who never underwent reconstruction (adjusted HR = 0.83, 95% CI = 0.69–0.99).ConclusionsThese results indicate that ACL reconstruction might not provide complete protection from OA development after traumatic knee injury but does yield a lower cumulative incidence of OA development and TKR. Moreover, based on the present study, ACL-injured patients should undergo reconstruction as early as possible (within one month) to lower the risk of OA.

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Knee stability after arthroscopic anterior cruciate ligament reconstruction using the middle third of the patellar ligament and quadrupled hamstring tendons grafts – A two-year follow-up

Cited by 7 publications

References 30 publications

Cruciate ligament, patellar tendon, and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds

Cruciate ligament, patellar tendon, and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds

Tendon‐derived progenitor cells improve healing of collagenase‐induced flexor tendinitis

Association of anterior cruciate ligament injury with knee osteoarthritis and total knee replacement: A retrospective cohort study from the Taiwan National Health Insurance Database

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