Kluyvera ascorbata infections in children: a case series

Abstract

Kluyvera is a relatively newly described member of the Enterobacteriaceae family that rarely causes infections in humans. In the pediatric population, it is described in association with clinically significant infections ranging from urinary tract infections to sepsis with multiorgan failure. Our aim is to determine the clinical significance of K. ascorbata infections in the pediatric population at our institution. We retrospectively analyzed clinical microbiology data as from 2006 and identified four clinically significant isolates in this period. The isolates were from four cases who presented with sepsis, bacteremia associated with central venous catheter, pyelonephritis and intraabdominal collection. The ages of these patients ranged between seven months to 17 years. All patients received prompt antimicrobial treatment on the basis of susceptibility testing and good clinical response was obtained in all patients. Successful treatment options include third-generation cephalosporins, aminoglycosides, betalactams with beta-lactamase inhibitors and carbapenems. Clinicians should be aware of the spectrum of disease and increasing clinical importance associated with this pathogen. (Turk Pediatri Ars 2015; 50: 123-8)

Impact of delivery mode on the colostrum microbiota composition

“…and Kluyvera spp. whose involvement in human skin and tissue infections have already been observed [ 18 – 20 ]. The aforementioned interaction implies a potential biological correlation between these four bacterial genera that may have a deeper impact on the host’s health than the significant greater abundance of Haemophilus spp.…”

Complete Genome Sequence of blaIMP–6-Positive Metakosakonia sp. MRY16-398 Isolate From the Ascites of a Diverticulitis Patient

“…Kluyvera is a group of gram-negative rod-shaped bacteria and is a member of the Enterobacteriaceae family; the genus contains four species, namely Kluyvera ascorbata , Kluyvera cryocrescens , Kluyvera georgiana , and Kluyvera intermedia , which have all been found in humans ( Farmer et al, 1981 ). K. ascorbata and K. cryocrescens were reported as potential pathogens that are associated with sepsis, bacteremia, catheter-associated urinary tract infections, pyelonephritis, and intraabdominal symptoms in immunocompromised hosts ( Karadag Oncel et al, 2015 ; Yoshino et al, 2016 ).…”

Kluyvera ascorbata infection in a neonate

“…Kluyvera ascorbata has been implicated as an opportunistic pathogen in neonates . Therefore, to reduce neonatal morbidity and mortality, prompt identification of Kluyvera as the causative agent and use of appropriate antibiotics are mandatory.…”

“…Kluyvera is a species of Gram‐negative bacilli belonging to the Enterobacteriaceae family, which includes K. ascorbata , K. cochleae , K. cryocrescens , and K. georgiana . Kluyvera species have been regarded as non‐pathogenic bacteria and part of the normal flora of the human gastrointestinal tract.…”

“…Kluyvera species have been regarded as non‐pathogenic bacteria and part of the normal flora of the human gastrointestinal tract. Recently, Kluyvera has been associated with clinically significant infections such as urinary tract infection (UTI), bacteremia, and severe sepsis . Of the 15 clinically significant cases of pediatric Kluyvera infection, three cases of fatal infection have been documented, but only a few neonatal cases of Kluyvera infection have been reported …”