Klotho and Renal Fibrosis

Vahed, Sepideh Zununi; Nikasa, Parisa; Ardalan, Mohammadreza

doi:10.5812/numonthly.16179

Cited by 11 publications

(6 citation statements)

References 29 publications

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“…The kidney is the major source of sKl production ( 18 ), and membrane-bound Klotho is also a co-activator of FGF23, which is prominently expressed in distal convoluted tubule (DCT) and proximal convoluted tubule (PCT) cells; these locations are essential for its function as a phosphaturic substance ( 11 ). Klotho deficiency is an early biomarker for chronic kidney disease (CKD), and a progressive decline in urine Klotho occurs with CKD progression ( 6 , 11 , 19 ). Endogenous Klotho may inﬂuence the processes of inﬂammation, oxidative stress, and vascular calciﬁcation and remodeling ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Serum Klotho Levels in Trained Athletes

et al. 2016

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Background:Klotho is an anti-aging protein that is predominantly secreted by the kidneys.Objectives:The aim of the study was to measure and compare the circulating Klotho levels in the serum of trained athletes and in healthy, non-athlete controls.Materials and Methods:Thirty trained football players were enrolled and their serum Klotho levels were measured the morning after their last evening exercise training.Results:The plasma free Klotho concentration was significantly higher in the athlete group (3.375 ± 1.48 ng/mL) compared to the non-athletes (1.39 ± 0.43 ng/mL) (P < 0.05). Serum levels of cholesterol, triglycerides, calcium, and phosphorus were not significantly different between the two groups.Conclusions:Regular aerobic exercise could increase plasma Klotho levels, and this could be an explanation for exercise-related anti-aging effects.

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Section: Discussionmentioning

confidence: 99%

Serum Klotho Levels in Trained Athletes

et al. 2016

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“…Therapeutic approaches based on inhibiting TGF-β/Smad signaling have been reported to reduce renal injury and fibrosis in many disease models, whereas overexpressing TGF-β1 induces renal fibrosis (Ai et al, 2015; Border and Noble, 1998; Chuang et al, 2014; Decleves and Sharma, 2014; Delle et al, 2012; Doi et al, 2011; Hu et al, 2013; Hu et al, 2016; Kania et al, 2013; Lee et al, 2015; Liu et al, 2015; Malaga-Dieguez et al, 2015; Meng et al, 2016; Morinaga et al, 2013; Neyra and Hu, 2016; Soler et al, 2012; Tampe and Zeisberg, 2014; Wang et al, 2011; Williams et al, 2013; Zhang et al, 2016; Zununi Vahed et al, 2013). Results of a phase I clinical trial suggested that fresolimumab, an anti-TGF-β1 antibody, is well-tolerated in patients with primary resistant FSGS.…”

Section: Profibrotic Cytokinesmentioning

confidence: 99%

Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets

Booz

Wang

et al. 2018

European Journal of Pharmacology

246

200

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Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal fibrosis is the final common pathway of progressive kidney disease irrespective of the initial injury. Considerable evidence now indicates that renal inflammation plays a central role in the initiation and progression of CKD. Some of the inflammatory signaling molecules involved in CKD include: monocyte chemoattractant protein-1 (MCP-1), bradykinin B receptor (BR), nuclear factor κB (NF-κB), tumor necrosis factor-α (TNFα), transforming growth factor β (TGF-β), and platelet-derived growth factor (PDGF). Multiple antifibrotic factors, such as interleukin-10 (IL-10), interferon-γ (IFN-γ), bone morphogenetic protein-7 (BMP-7), hepatocyte growth factor (HGF) are also downregulated in CKD. Therefore, restoration of the proper balance between pro- and antifibrotic signaling pathways could serve as a guiding principle for the design of new antifibrotic strategies that simultaneously target many pathways. The purpose of this review is to summarize the existing body of knowledge regarding activation of cytokine pathways and infiltration of inflammatory cells as a starting point for developing novel antifibrotic therapies to prevent progression of CKD.

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“…Serum creatinine and glomerular filtration rate (GFR) have limited roles in estimating the histopathologic changes. Recent progress in the area of microRNA has hold a great promise to identify the renal fibrosis ( 21 , 22 ). In addition, miR-142-5p is a promising biomarker for long-term renal allograft monitoring ( 22 ).…”

Section: Resultsmentioning

confidence: 99%

Global Scientific Vision With Local Vigilance: Renal Transplantation in Developing Countries

Ardalan

2014

Nephro Urol Mon

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Context:Renal Transplantation is the most effective treatment for patients with end-stage renal disease, which is fortunately available in the developing countries, even for poor people. Nonetheless, the way forward should be the implementation of advanced science of transplantation, allograft monitoring abilities, knowledge about the epidemiology of renal disease in any specific region, awareness about the influence of ethenic and genetic factors immunosuppressant bioavailability, and post-transplant complications all strongly affecting the patients and allograft survival.Evidence Acquisitions:In this process we searched mainly in PubMed, Web of Science and Google Scholar data bases for key words of renal allograft monitoring, post-transplant infections, renal/kidney transplantation and Iran. We followed the cross articles to follow our main idea to find a connection between modern advancement in renal allograft monitoring and our practice in developing countries. Another focus was on the special infectious and non-infection complication that do exist in specific region and need specific considerations.Results:Implementation of modern techniques of immune monitoring, allograft function, awareness about the specific infectious and non-infectious disease in each region improves the quality of renal transplantation.Conclusions:We need to combine the advance scientific vision with local vigilance to achieve the best outcome in renal allograft recipients

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Klotho and Renal Fibrosis

Cited by 11 publications

References 29 publications

Serum Klotho Levels in Trained Athletes

Serum Klotho Levels in Trained Athletes

Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets

Global Scientific Vision With Local Vigilance: Renal Transplantation in Developing Countries

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