Serum Klotho Levels in Trained Athletes

Mostafidi, Elmira; Moeen, Akbar; Nasri, Hamid; Hagjo, Amir Ghorbani; Ardalan, Mohammadreza

doi:10.5812/numonthly.30245

Cited by 27 publications

(16 citation statements)

References 25 publications

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“…In SSc patients, serum klotho concentration ranged from 0.0 to 2.50 ng/mL (median 0.30 ng/mL, IQR 0.79). These values are in line with previous results obtained from healthy population by means of ELISA assays [ 3 , 4 ]. Serum klotho was not associated to sex or age in the group of scleroderma patients.…”

Section: Resultssupporting

confidence: 93%

Measurement of Serum Klotho in Systemic Sclerosis

et al. 2017

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Background The aim of our study was to evaluate the serum concentration of klotho in a cohort of systemic sclerosis (SSc) patients compared to that of healthy controls and to correlate its levels with the degree and the kind of organ involvement. Methods Blood samples obtained from both patients and controls were collected and analysed by an ELISA test for the determination of human soluble klotho. Scleroderma patients were evaluated for disease activity through clinical, laboratory, and instrumental assessment. Results Our cohort consisted of 81 SSc patients (74 females, mean age 63.9 ± 13.1 years) and 136 healthy controls (78 females, mean age 50.5 ± 10.7 years). When matched for age, serum klotho concentration significantly differed between controls and patients (p < 0.001). However, in SSc patients, we did not find any significant association between serum klotho and clinical, laboratory, and instrumental findings. Lower serum levels of klotho were detected in 4 patients who were anticitrullinated peptide antibody (ACPA) positive (p = 0.005). Conclusions Our data show a lower concentration of klotho in the serum of SSc patients compared to that of healthy controls, without any significant association with clinical manifestations and laboratory and instrumental findings. The association between serum klotho and ACPA positivity requires further investigation.

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Section: Resultssupporting

confidence: 93%

Measurement of Serum Klotho in Systemic Sclerosis

et al. 2017

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“…These results are in accordance with the hypothesis that a deficit of klotho may account for many manifestations of the disease, including ulcer healing delay, lung fibrosis, calcinosis, renal crisis. Although a standardised range for serum klotho is unavailable, our results are in line with serum klotho levels shown in previous studies on human healthy subjects (17,18). However, due the consecutive enrolment and the design of the study, the cohort of patients significantly differed from controls with respect to gender and age.…”

Section: Original Papersupporting

confidence: 78%

The role of klotho in systemic sclerosis

Talotta¹,

Bongiovanni²,

Letizia³

et al. 2017

Reumatismo

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The aim was to evaluate the role of klotho in the pathogenesis of systemic sclerosis (SSc), through the measurement of its serum concentration in SSc patients compared to healthy controls, and to assess the association with cutaneous and visceral involvement. Blood samples obtained from both SSc patients and healthy controls were analysed by an ELISA assay for the detection of human klotho. SSc patients were globally evaluated for disease activity and assessed through the modified Rodnan’s Skin Score, Medsger’s scale, pulmonary function tests, 2D-echocardiography, nailfold capillaroscopy and laboratory tests. Our cohort consisted of 69 SSc patients (61 females, mean age 64.5±12.5 years, median disease duration 9.0 (IQR 8) years) and 77 healthy controls (28 females, mean age 49.7±10.2 years). In the group of SSc patients, 19 (27.5%) suffered from a diffuse form of SSc. All patients were receiving IV prostanoids, and some of them were concomitantly treated with immunosuppressive drugs (prednisone, hydroxychloroquine, mofetil mycophenolate, methotrexate, cyclosporin A and azathioprine). The median serum concentration of klotho was significantly lower in patients compared to controls (0.23 ng/mL vs 0.60 ng/mL; p<0.001). However, Spearman’s test showed no significant association between klotho serum levels and disease activity, concerning either clinical, laboratory or instrumental findings. Our data show a significant deficit of klotho in SSc patients although any significant association was detected between klotho serum concentration and the clinical, laboratory or instrumental features of the disease. However, due to the limits of the study, further investigations are required.

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“…In the context of AE and NMES, biomarkers of particular interest suggested to be responsive to physical activity include: brain derived neurotrophic factor (BDNF), which is involved in neurogenesis, vascular endothelial growth factor (VEGF)-A involved in angiogenesis, and insulin-like growth factor-1 (IGF-1) promoting growth and maintenance of muscle 21 , 22 . More recently, it has been suggested that Klotho, known for its anti-aging effects and neuroprotective activity 23 – 25 , may also be responsive to exercise 26 , 27 .…”

Section: Introductionmentioning

confidence: 99%

Biological effects of dosing aerobic exercise and neuromuscular electrical stimulation in rats

Dalise

Cavalli

Ghuman

et al. 2017

Sci Rep

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Aerobic exercise (AE) and non-aerobic neuromuscular electric stimulation (NMES) are common interventions used in physical therapy. We explored the dose-dependency (low, medium, high) of these interventions on biochemical factors, such as brain derived neurotrophic growth factor (BDNF), vascular endothelial growth factor-A (VEGF-A), insulin-like growth factor-1 (IGF-1) and Klotho, in the blood and brain of normal rats, as well as a treadmill-based maximum capacity test (MCT). A medium dose of AE produced the most improvement in MCT with dose-dependent changes in Klotho in the blood. A dose-dependent increase of BDNF was evident following completion of an NMES protocol, but there was no improvement in MCT performance. Gene expression in the hippocampus was increased after both AE and NMES, with IGF-1 being a signaling molecule that correlated with MCT performance in the AE conditions, but also highly correlated with VEGF-A and Klotho. Blood Klotho levels can serve as a biomarker of therapeutic dosing of AE, whereas IGF-1 is a key molecule coupled to gene expression of other molecules in the hippocampus. This approach provides a translatable paradigm to investigate the mode and mechanism of action of interventions employed in physical therapy that can improve our understanding of how these factors change under pathological conditions.

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Serum Klotho Levels in Trained Athletes

Cited by 27 publications

References 25 publications

Measurement of Serum Klotho in Systemic Sclerosis

Measurement of Serum Klotho in Systemic Sclerosis

The role of klotho in systemic sclerosis

Biological effects of dosing aerobic exercise and neuromuscular electrical stimulation in rats

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