Biological effects of dosing aerobic exercise and neuromuscular electrical stimulation in rats

Dalise, Stefania; Cavalli, Loredana; Ghuman, Harmanvir; Wahlberg, Brendon; Gerwig, Madeline; Chisari, Carmelo; Ambrosio, Fabrisia; Modo, Michel

doi:10.1038/s41598-017-11260-7

Cited by 33 publications

(36 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The expression of α-klotho is regulated by many factors. Exercise (both acute and chronic) was reported to affect the expression of α-klotho in the brain and kidneys (Ji et al, 2018), as well as the level of soluble α-klotho in the serum (Matsubara et al, 2014;Santos-Dias et al, 2016;Dalise et al, 2017;Amaro-Gahete et al, 2019). But the physiological mechanism is unclear.…”

Section: Discussionmentioning

confidence: 99%

α-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise

Rao

Zheng

et al. 2019

Front. Physiol.

View full text Add to dashboard Cite

α-Klotho, a multifunctional protein, has been demonstrated to protect tissues from injury via anti-oxidation and anti-inflammatory effects. The expression of α-klotho is regulated by several physiological and pathological factors, including acute inflammatory stress, oxidative stress, hypertension, and chronic renal failure. Exhaustive exercise has been reported to result in tissue damage, which is induced by inflammation, oxidative stress, and energy metabolism disturbance. However, little is known about the effects of exhaustive exercise on the expression of α-klotho in various tissues. To determine the effects, the treadmill exhaustion test in mice was performed and the mice were sacrificed at different time points following exhaustive exercise. Our results confirmed that the full-length (130 kDa) and shorter-form (65 kDa) α-klotho were primarily expressed in the kidneys. Moreover, we found that, except for the kidneys and brain, other tissues primarily expressed the shorter-form α-klotho, including liver, which was in contrast to previous reports. Furthermore, the shorter-form α-klotho was decreased immediately following the acute exhaustive exercise and was then restored to the pre-exercise level or even higher levels in the next few days. Our results indicate that α-klotho may play a key role in the body exhaustion and recovery following exhaustive exercise.

show abstract

Section: Discussionmentioning

confidence: 99%

α-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise

Rao

Zheng

et al. 2019

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…Tissue replacement is expected to restore function of lost tissue, but akin to learning in development it can be expected that new tissue needs to be trained to function appropriately (Dobrossy and Dunnett, 2001; Dobrossy and Nikkhah, 2012). In conventional rehabilitation, plasticity of existing networks can be induced by exercise (Dobkin, 2008), which leads to the release of growth factors, such as BDNF, that support synaptogenesis (Dalise et al, 2017). To ensure a functional synapses formation, task integration is required (Rensink et al, 2009).…”

Section: Training Of Functional Circuitrymentioning

confidence: 99%

Bioscaffold-Induced Brain Tissue Regeneration

Modo

2019

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

Brain tissue lost after a stroke is not regenerated, although a repair response associated with neurogenesis does occur. A failure to regenerate functional brain tissue is not caused by the lack of available neural cells, but rather the absence of structural support to permit a repopulation of the lesion cavity. Inductive bioscaffolds can provide this support and promote the invasion of host cells into the tissue void. The putative mechanisms of bioscaffold degradation and its pivotal role to permit invasion of neural cells are reviewed and discussed in comparison to peripheral wound healing. Key differences between regenerating and non-regenerating tissues are contrasted in an evolutionary context, with a special focus on the neurogenic response as a conditio sine qua non for brain regeneration. The pivotal role of the immune system in biodegradation and the formation of a neovasculature are contextualized with regeneration of peripheral soft tissues. The application of rehabilitation to integrate newly forming brain tissue is suggested as necessary to develop functional tissue that can alleviate behavioral impairments. Pertinent aspects of brain tissue development are considered to provide guidance to produce a metabolically and functionally integrated de novo tissue. Although little is currently known about mechanisms involved in brain tissue regeneration, this review outlines the various components and their interplay to provide a framework for ongoing and future studies. It is envisaged that a better understanding of the mechanisms involved in brain tissue regeneration will improve the design of biomaterials and the methods used for implantation, as well as rehabilitation strategies that support the restoration of behavioral functions.

show abstract

“…In addition to ApoE4 carriership, exercise intensity may determine the magnitude of exercise effects. Exerciseinduced changes in the aforementioned neurobiological factors may be dose-dependent, as evidenced by studies in rodents [37,38] and humans [18,39,40]. Furthermore, exercising at moderate-to-vigorous intensities is recommended over lighter intensities for cardiovascular, muscular, and neuromotor benefits in healthy young and old adults [41].…”

Section: Introductionmentioning

confidence: 99%

Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial

et al. 2020

View full text Add to dashboard Cite

Background: Potential moderators such as exercise intensity or apolipoprotein-E4 (ApoE4) carriership may determine the magnitude of exercise effects on physical and cognitive functions in patients with dementia (PwD). We determined the effects of a 24-week aerobic and strength training program with a low-and high-intensity phase on physical and cognitive function. Methods: In an assessor-blinded randomized trial, 91 PwD (all-cause dementia, recruited from daycare and residential care facilities, age 82.3 ± 7.0 years, 59 women, Mini-Mental State Examination 20.2 ± 4.4) were allocated to the exercise or control group. In the exercise group, PwD participated in a walking and lower limb strength training program with 12 weeks low-and 12 weeks high-intensity training offered three times/week. Attention-matched control participants performed flexibility exercises and recreational activities. We assessed adherence, compliance, and exercise intensity for each session. We assessed physical (endurance, gait speed, mobility, balance, leg strength) and cognitive (verbal memory, visual memory, executive function, inhibitory control, psychomotor speed) functions with performance-based tests at baseline and after 6, 12, 18, 24, and 36 weeks (follow-up). ApoE4 carriership was determined post-intervention.Results: Sixty-nine PwD were analyzed. Their mean attendance was~60% during the study period. There were no significant effects of the exercise vs. control intervention on endurance, mobility, balance, and leg strength in favor of the exercise group (Cohen's d = 0.13-0.18). Gait speed significantly improved with~0.05 m/s after the high-intensity phase for exercise participants (Cohen's d = 0.41) but declined at follow-up. There were no significant effects of the exercise vs. control intervention on any of the cognitive measures (Cohen's d~− 0.04). ApoE4 carriership did not significantly moderate exercise effects on physical or cognitive function.(Continued on next page) Conclusions: Exercise was superior to control activities for gait speed in our sample of PwD. However, the training effect provided no protection for mobility loss after detraining (follow-up). There were no beneficial effects of the exercise vs. control group on cognitive function. Exercise intensity moderated the effects of exercise on gait speed. ApoE4 carriership moderated the effect of exercise on global cognition only (trend level).

show abstract

Biological effects of dosing aerobic exercise and neuromuscular electrical stimulation in rats

Cited by 33 publications

References 65 publications

α-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise

α-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise

Bioscaffold-Induced Brain Tissue Regeneration

Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial

Contact Info

Product

Resources

About