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Karpov, K. A.; Nazarenko, A. V.; Pekarevskii, B. V.; Potekhin, V. M.

doi:10.1023/a:1013081926468

Cited by 12 publications

(1 citation statement)

References 3 publications

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“…They occupy an important position in medicinal chemistry, presenting a wide range of bioactivities. As medicines, many of them display including antibacterial and antifungal, 1−3 anti-HIV, 4,5 hypertension, 6,7 anti-inflammatory, 8 anticancer, 9 anti-convulsant, 10 antiinflammation, 11 antidepressant and tubercular activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Some Novel [4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-benzylidene-amines and N-[4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-N'-benzylidene-hydrazines

Mekala¹,

Danda²,

Gadegoni³

2013

Journal of the Korean Chemical Society

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ABSTRACT. A new family of thiazole heterocycles, namely [4-(1H-benzoimidazol-2-yl)-thiazol-2-yl]-benzylidene-amines has been synthesized by the condensation of 4-(1H-Benzoimidazol-2-yl)-thiazol-2-ylamine with various aromatic aldehydes and N-[4-(1H-benzoimidazol-2-yl)-thiazol-2-yl]-N'-benzylidene-hydrazines through the cyclization of 1-(1H-benzoimidazol-2-yl)-2-bromo-ethanone with arylthiosemicarbazones. The target compounds are achieved by using 1-(1H-Benzoimidazol-2-yl)-ethanone as starting material. The chemical structures of all newly synthesized compounds were confirmed by their IR, 1 H NMR and Mass spectral data. Further the compounds were used to evaluate their antimicrobial activity and found that the appreciable antimicrobial activity by some of the title compounds.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Some Novel [4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-benzylidene-amines and N-[4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-N'-benzylidene-hydrazines

Mekala¹,

Danda²,

Gadegoni³

2013

Journal of the Korean Chemical Society

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2‐Amino thiazole derivatives as inhibitors of some metabolic enzymes: An in vitro and in silico study

Korkmaz

2022

Biotech and App Biochem

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The thiazole derivatives are desirable compounds in the evaluation of their biological activities such as antiprotozoal antibacterial, antifungal, antituberculosis. Considering the medical application potential of 2‐amino thiazole compounds, we aimed to determine the effects of 2‐amino thiazole derivatives on the activities of carbonic anhydrase I–II isoenzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among the chemicals we used in our study, 2‐amino‐4‐(4‐chlorophenyl)thiazole compound exhibited the best inhibition against hCA I with Ki of 0.008 ± 0.001 μM. The 2‐amino‐4‐(4‐bromophenyl)thiazole compound exhibited the best inhibition against hCA II, AChE, and BChE with Ki of 0.124 ± 0.017, 0.129 ± 0.030, and 0.083 ± 0.041 μM, respectively. Molecular docking analysis showed that compound 2‐amino‐4‐(5,6,7,8‐tetrahydro‐2‐naphthyl)thiazole had the highest inhibitory potency against hCA I, hCA II, AChE, BChE with the estimated binding energy of −6.75, −7.61, −7.86, −7.96 kcal/mol, respectively.

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A 4-(o-methoxyphenyl)-2-aminothiazole: an anti-quorum sensing compound

Karale

Lawand

et al. 2012

Med Chem Res

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Untitled

Cited by 12 publications

References 3 publications

Synthesis and Biological Evaluation of Some Novel [4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-benzylidene-amines and N-[4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-N'-benzylidene-hydrazines

Synthesis and Biological Evaluation of Some Novel [4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-benzylidene-amines and N-[4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-N'-benzylidene-hydrazines

2‐Amino thiazole derivatives as inhibitors of some metabolic enzymes: An in vitro and in silico study

A 4-(o-methoxyphenyl)-2-aminothiazole: an anti-quorum sensing compound

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