Kisspeptins and Glucose Homeostasis in Pregnancy: Implications for Gestational Diabetes Mellitus—a Review Article

Musa, Ezekiel; Matjila, Mushi; Levitt, Naomi

doi:10.1007/s43032-020-00437-7

Cited by 7 publications

(6 citation statements)

References 58 publications

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“…In addition, a previous study found that CTRP6 knockdown improved insulin sensitivity and reduced diet-induced obesity in mice 19 . Although during normal pregnancy, in order to provide maximum nutrition for fetal development, the mother exhibits physiological insulin resistance, pathological insulin resistance is the typical characteristic of GDM patients 26,27 . However, it has not been reported whether the expression level of CTRP6 is abnormal expression in GDM patients at different stages of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Dynamic changes in the expression of C1q/TNF-α-related protein 6 (CTRP6) in Gestational Diabetes Mellitus

Jiang,

Wei,

Chen

et al. 2023

Preprint

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Aim C1q/TNF-related protein 6 (CTRP6) is a novel adipokine involved in insulin resistance. Thus, we aim to investigate the expression profile of CTRP6 in plasma, adipose tissue and placenta of GDM patients and mice. Methods Pregnant women (GDM n = 9, control n = 10) with a scheduled caesarean section delivery were recruited. High fat diet (HFD) induced C57BL/6 pregnancy mice were chosen as an animal model of GDM. Circulating levels of CTRP6 and adiponectin were examined by ELISA. CTRP6 expression in adipose tissue and placenta were detected by real time qPCR and WB. Result The plasma CTRP6 level were decreased during first (for mice)/second and third trimesters, while increased at delivery in GDM patients and mice. Plasma CTRP6 level were significantly correlated with WBC, systolic pressure, diastolic pressure and fasting blood glucose. Moreover, CTRP6 mRNA expression in subcutaneous (sWAT) and omental white adipose tissue (oWAT) as well as placenta were significantly higher in GDM human at cesarean delivery. Furthermore, the mRNA expression of Ctrp6 were increased in sWAT and visceral WAT (vWAT) whilst decreased in interscapular brown adipose tissue (iBAT) of GDM mice at cesarean delivery. Conclusion Dynamically expressed CTRP6 may be served as a candidate target for treatment of GDM.

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Section: Discussionmentioning

confidence: 99%

Dynamic changes in the expression of C1q/TNF-α-related protein 6 (CTRP6) in Gestational Diabetes Mellitus

Jiang,

Wei,

Chen

et al. 2023

Preprint

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“…For diabetes during pregnancy, given the tremendous effects of medication on the fetus, the control of glucose levels is mainly achieved through consistent and appropriate exercise and dietary control. Individualized nutritional intervention is utilized to reduce the risk arising from GDM by acting as a regulator of the nutritional input of patients to stabilize plasma sugar levels [ 14 – 17 ]. It was demonstrated in clinical trials that individualized nutritional intervention produced a promising effect on controlling and stabilizing blood sugar levels, indicating the great potential of individualized nutritional intervention in stabilizing plasma glucose in GDM patients [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Study on the Effects of Individualized Nutritional Intervention on Pregnancy Outcome and Neonatal Immune Function in Patients with Gestational Diabetes Mellitus

Zhang

Miao

2022

BioMed Research International

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Objective. To study the effects of individualized nutritional intervention on pregnancy outcome and neonatal immune function in patients with gestational diabetes mellitus (GDM). Methods. A retrospective analysis was conducted on 100 GDM patients from the obstetrics and gynecology department of our institute between February 2019 and February 2020. The patients were allocated into the control group given regular intervention and the experimental group given individualized nutritional intervention according to different intervention measures, with 50 cases in each group. The comparison was carried out for patients in the two groups with regard to their modality of delivery, neonatal health, their plasma glucose in fasting state, 2 h after eating, and before bedtime; glycohemoglobin at 8 months of pregnancy, at 9 months of pregnancy, during labor, and 1 month after delivery; their complications; and neonatal CD3+, CD4+, and CD8+ levels. Results. The experimental group outperformed the control group in terms of the spontaneous delivery rate, the number of healthy neonates, and neonatal CD3+, CD4+, and CD8+ levels ( P < 0.05 ). The plasma glucose in fasting state, 2 h after eating, and before bedtime; the glycohemoglobin at 8 months of pregnancy, at 9 months of pregnancy, during labor, and 1 month after delivery; and the incidence of complications of the experimental group were significantly lower than those of the control group ( P < 0.05 ). Conclusion. Individualized nutritional intervention increases the rate of spontaneous delivery in GDM patients, enhances neonatal immune function, stabilizes plasma glucose, and reduces complications.

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“…Diabetes mellitus is associated with irregular glucose homeostasis, so the effective control of blood glucose level is critical in preventing or reversing diabetic complications and improving life quality in diabetic patients [ 68 ]. In male HFD Wistar rats, M. charantia fruit extract notably improved glucose tolerance [ 51 ].…”

Section: Antidiabetic Activity Of M Charantiamentioning

confidence: 99%

Bioactives of Momordica charantia as Potential Anti-Diabetic/Hypoglycemic Agents

Zeng

et al. 2022

Molecules

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Momordica charantia L., a member of the Curcubitaceae family, has traditionally been used as herbal medicine and as a vegetable. Functional ingredients of M. charantia play important roles in body health and human nutrition, which can be used directly or indirectly in treating or preventing hyperglycemia-related chronic diseases in humans. The hypoglycemic effects of M. charantia have been known for years. In this paper, the research progress of M. charantia phytobioactives and their hypoglycemic effects and related mechanisms, especially relating to diabetes mellitus, has been reviewed. Moreover, the clinical application of M. charantia in treating diabetes mellitus is also discussed, hoping to broaden the application of M. charantia as functional food.

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Kisspeptins and Glucose Homeostasis in Pregnancy: Implications for Gestational Diabetes Mellitus—a Review Article

Cited by 7 publications

References 58 publications

Dynamic changes in the expression of C1q/TNF-α-related protein 6 (CTRP6) in Gestational Diabetes Mellitus

Dynamic changes in the expression of C1q/TNF-α-related protein 6 (CTRP6) in Gestational Diabetes Mellitus

Study on the Effects of Individualized Nutritional Intervention on Pregnancy Outcome and Neonatal Immune Function in Patients with Gestational Diabetes Mellitus

Bioactives of Momordica charantia as Potential Anti-Diabetic/Hypoglycemic Agents

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