Kinetics of degradation of cefaclor: I. Effects of temperature, phosphate buffer, pH and copper(II) ion on the rate of degradation

Dimitrovska, Aneta; Стојаноски, Киро; Dorevski, K.

doi:10.1016/0378-5173(94)00244-y

Cited by 19 publications

(6 citation statements)

References 17 publications

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“…The peak at 264 nm (peak B) disappeared, as a result of C-N bond cleavage in the four-membered amido ring. This behaviour is similar to degradation of all cephalosporins 17,18 . However, a new absorption peak at 342 nm (peak C) was observed in the UV absorption spectrum.…”

Section: Resultssupporting

confidence: 71%

Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide

Shantier¹,

Gadkariem²,

Ibrahim³

et al. 2010

Journal of Chemistry

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A simple spectrophotometric method was developed for the determination of cefadroxil in pure bulk and in capsules forms. The method is based on a direct reaction between cefadroxil and sodium hydroxide (1 N). A product with λmaxat 342 nm and molar absorptivity of 7.9x103L mol-1cm-1is formed after heating cefadroxil with sodium hydroxide (1 N) for 30 minutes. The absorbance-concentration plot was rectilinear over the range 5-25 μg/mL with correlation coefficient values not less than 0.999. The detection limit (LOD) and quantification limit (LOQ) were 0.693 μg/mL and 2.31 μg/mL. The method was validated using the BP liquid chromatographic method for cefadroxil assay. The results obtained by the developed method for the capsules dosage form were statistically compared with those of the BP liquid chromatography method and evaluated at 95% confidence limits.

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Section: Resultssupporting

confidence: 71%

Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide

Shantier¹,

Gadkariem²,

Ibrahim³

et al. 2010

Journal of Chemistry

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“…Besides product analysis by LC/MS, previous studies have monitored the decrease of absorbance at around 264 nm as the indicator of breakage of the β-lactam ring for cephalosporin cefaclor. 36,43 Similarly, we monitored the absorbance at 262 nm for the transformation of CFX in the presence of metal ions (Zn II or Cu II ) or at high pH. Results (Figure S11) showed that the absorbance at 262 nm gradually decreased in the degradation of CFX by Zn II or at high pH, consistent with hydrolytic cleavage of the β-lactam ring.…”

Section: Environmental Science and Technologymentioning

confidence: 92%

Multiple Roles of Cu(II) in Catalyzing Hydrolysis and Oxidation of β-Lactam Antibiotics

Chen

Sun

Zhang

et al. 2016

Environ. Sci. Technol.

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The widely used β-lactam antibiotics such as penicillins and cephalosporins are known to be susceptible to Cu-catalyzed hydrolysis at their four-membered β-lactam ring. However, this study elucidates that Cu can in fact play multiple roles in promoting the hydrolysis and/or oxidation of β-lactam antibiotics under environmental aquatic conditions (pH 5.0-9.0 and 22 °C), depending on β-lactams' structural characteristics and solution pH. Most significantly, the β-lactam antibiotics that contain a phenylglycine primary amine group on the side chain can undergo direct oxidation by Cu via this functional group. On the other hand, the β-lactam ring of penicillins is susceptible to Cu-catalyzed hydrolysis, followed by oxidation of the hydrolysis product by Cu. In contrast, the β-lactam ring of cephalosporins is susceptible to Cu-catalyzed hydrolysis only. Solution pH influences the Cu-promoted transformation by affecting the β-lactam and Cu complexation through protonation/deprotonation of critical organic functional groups. When Cu acts as an oxidant to promote the transformation of β-lactam antibiotics to yield Cu, the overall role of Cu appears catalytic if the reaction occurs under ambient atmospheric condition, due to quick oxidation of Cu by oxygen to regenerate Cu. Compared to earlier literature that largely assumed only the hydrolytic catalyst role of Cu in promoting degradation of β-lactam antibiotics, the oxidative roles of Cu identified by this study mark important contributions to a more accurate mechanistic understanding.

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“…Its antibacterial activity is dependent on the presence of the ß-lactam functionality which is not stable in aqueous conditions. This instability of those drugs leads them to undergo chemical degradation in alkaline medium [13,14].…”

Section: Resultsmentioning

confidence: 99%

Differential Spectrophotometric Method for Determination of Cefquinome Sulphate

Shantier¹

2014

BJPR

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Differential first derivative (ΔD 1 ) method is developed for the quantitative analysis of cefquinome sulphate (CS) in bulk and dosage form. The method is based on measuring the ΔD 1 of CS in alkaline solutions against its neutral aqueous solutions as blanks. The proposed method is sensitive and highly specific, since the interference of the excipients or impurities is nullified. Beer's law was obeyed over the concentration range 4-20 µg/mL with a limit of detection and limit of quantification 1.5 µg/mL and 4.8 µg/mL respectively.

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Kinetics of degradation of cefaclor: I. Effects of temperature, phosphate buffer, pH and copper(II) ion on the rate of degradation

Cited by 19 publications

References 17 publications

Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide

Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide

Multiple Roles of Cu(II) in Catalyzing Hydrolysis and Oxidation of β-Lactam Antibiotics

Differential Spectrophotometric Method for Determination of Cefquinome Sulphate

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