Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide

Shantier, Shaza W.; Gadkariem, Elrasheed A.; Ibrahim, Kamal E.; El-Obeid, Humeida A.

doi:10.1155/2011/568620

Cited by 10 publications

(12 citation statements)

References 8 publications

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“…A variety of techniques have been used for the determination of cefadroxil: Chromatography (Ting, 1988;Manna and Valvo, 2004;Ravi et al, 2008;Karageorgou and Samanidou, 2010), flow injection (Awni et al, 1999;Thongpoon et al, 2006), and fluorometry (Yang et al, 1998;El-Walily et al, 1999). Also, various spectrophotometric methods have been used in the determination of cefadroxil in pure form and in its pharmaceuitical preparations used for various reagents such as diazotised benzocaine in the presence of triethylamine (El-Ashry et al, 2000), diazotised p-nitroaniline (Othman et al, 2006), 4-aminoantipyrine in the presence of an alkaline oxidizing agent (Aly et al,1994), 3-methyl-2-benzothiazolinone hydrazone hydrochloride in the presence of ceric ammonium sulphate, 4-aminophenazone in the presence of potassium hexacyanoferrate (III), 2,6-dichloroquinone-4-chlorimide (Sastry et al,1997), Cu(II) and V(V) in sulphuric acid (Badawy et al, 1993), Folin-Ciocalteu reagent in presence of sodium hydroxide and stannous chloride (Prasad et al, 2004), 2,3-dichloro-5,6-dicyano-1,4-benzoquinine (Al-Ghabsha et al, 2007), molybdophosphoric acid as an oxidising agent (Issopoulos,1989), Ce (IV) or Fe (III) (Salem and Saleh, 2002), bromated-bromide mixture in acidic medium (Mallapu et al, 2011) 1, 2naphthaquinone-4-sulphonic acid sodium in alkaline medium (Kumar et al, 2011), variamine (Pasha and Narayana, 2008), quercetin (Gamal et al, 2009) after nitration and subsequent complexation with a nucleophilic reagent, nitrosation and subsequent metal chelation, coupling with diazo reagent, reaction with copper and extraction of the resulting chelate into chloroform (Salem, 2004), sodium hydroxide (Shantier, 2011) and 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (Azza et al, 2010).…”

Section: Cefadroxilmentioning

confidence: 99%

Indirect Spectrophotometric Methods for the Determination of Cefadroxil in its Pure and Pharmaceutical Preparations

Omer¹,

Sehree²,

Othman³

2017

RJS

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Two spectrophotometric methods were described for the determination of cefadroxil in pure form and in its pharmaceutical preparations. They were based on the oxidation-reduction reaction between iron (III) and cefadroxil, the liberated Fe +2 is then reacted with 1,10-phenathroline (method I) or 2,2`-bipyridyl (method II) in acidic medium, the colored(red) complexes absorbed at 510 and 521 nm, respectively. Applying the optimum working conditions, cefadroxil can be determined over the concentration range of 0.5-5 and 0.5-6 µg.ml-1 with molar absorptivities of 1.141x10 5 and 6.308×10 4 l. mol-1 .cm-1 for method I and method II, respectively. The proposed methods were applied successfully to the determination of cefadroxil in various pharmaceutical preparations.

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Section: Cefadroxilmentioning

confidence: 99%

Indirect Spectrophotometric Methods for the Determination of Cefadroxil in its Pure and Pharmaceutical Preparations

Omer¹,

Sehree²,

Othman³

2017

RJS

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“…Ascorbic acid has been frequently utilized as an analytical reagent in pharmaceutical analysis. It was used for determination of cefprozil 7 , tobramycin 8 , penicillins and cephalosporins having α-aminoacyl functions 9,10 . Based on these reports, simple, sensitive and selective assay method was developed for the determination of ACA in bulk and injection forms using ascorbic acid.…”

Section: N Hmentioning

confidence: 99%

Development of Spectrophotometric Method for the Assay of Aminocaproic Acid in Dosage Forms Using Ascorbic Acid

2015

Chem Sci Trans

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A simple and selective colorimetric method was developed for the quantification of aminocaproic acid (ACA) in bulk and pharmaceutical formulations. The method was based on the coupling of ACA with ascorbic acid to give a colored product having analytically useful maxima at 390 and 530 nm. The factors; which are mainly concentration of ascorbic acid and heating time; affecting the color development were optimized and incorporated in the procedure. Regression analysis of Beer's plot showed good correlation (r=0.999) in a concentration range of 4-20 µg/mL. The molar absorptivity of the reaction product was 2492.6 L mole cm-1. The limit of detection was 0.86 µg/mL and 0.29 µg/mL at 390 nm and 530 nm respectively. The average recovery for the commercial preparation (Aminocaproic acid injections, 250 mg/ 20 mL) was 108.23±1.45% (n=3) which reflected no interference by the injection excipients. Based on the molar ratio, the reaction stoichiometry was found to be 1:1.

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“…Several analytical methods such as high performance liquid chromatography (HPLC) [7,11,12], liquid chromatography mass spectrometry (LC-MS) [13], electro chromatography [14,15], capillary zone electrophoresis [16][17][18][19], chemiluminescence [20][21][22], spectrophotometry [23][24][25] and electroanalytical techniques [26,27] were reported in the literature for the quantification and detection of the CFDL. Among them, spectrophotometry and electrochemical methods are preferable because ease of use, ecofriendly, and costeffective techniques for routine analysis of CFDL in complex matrices.…”

Section: Introductionmentioning

confidence: 99%

Analytical Comparison of Cefadroxil Determination by Square Wave Adsorptive Stripping Voltammetric and Spectrophotometric Methods

Saleem¹,

JA²,

HI³

et al. 2022

austinjanalpharmchem

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The goal of this research is to verify the proposed nano-silver amalgam paste electrode (Ag-nano-SPE) method to compare with a spectrophotometric technique based on derivatization with potassium periodate (KIO4 ), 2,4-dinitrophenyl hydrazine (DNP) and sodium hydroxide (NaOH) for the estimation of cefadroxil (CFDL) by square wave adsorptive stripping voltammetry (SWAV). The different parameters of both methods were optimized in detail separately and then compared their efficiency, selectivity, sensitivity and applications. The SWAV produced a reduction peak with a precise definition at -0.160 V while measuring CFDL in 0.04 molL-1 Britton–Robinson buffer at pH 4, accumulation potential (0.5 V), accumulation time (10 sec), and with stirring rate of 200 rpm. Whereas, the CFDL was measured at 515 nm (λmax) by UVVisible spectrophotometer after the derivatization by using 1.5 mL of 0.5 mM DNP, 1.5 mL of 6.52 mM KIO4 and 0.5 mL of 10 M NaOH solution at room temperature. The linear response for CFDL was found using the SWAV and spectrophotometric techniques along a linear dynamic range from 0.033 - 0.304 and 0.051 - 1.376 µM, respectively. However, the precision, detection limit and quantification limit of SWAV for CFDL in the samples and standards significantly lower (p <0.01) as compared to spectrophotometric method. This indicates that the SWAV is more sensitive and selective than the spectrophotometric technique for regular CFDL analysis.

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Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide

Cited by 10 publications

References 8 publications

Indirect Spectrophotometric Methods for the Determination of Cefadroxil in its Pure and Pharmaceutical Preparations

Indirect Spectrophotometric Methods for the Determination of Cefadroxil in its Pure and Pharmaceutical Preparations

Development of Spectrophotometric Method for the Assay of Aminocaproic Acid in Dosage Forms Using Ascorbic Acid

Analytical Comparison of Cefadroxil Determination by Square Wave Adsorptive Stripping Voltammetric and Spectrophotometric Methods

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