Kinetics of Acetylsalicylic Acid Disposition in Man

Plasma acetylsalicylate and salicylate and platelet cyclooxygenase activity following plain and enteric-coated aspirin.

“…9 The apparently slower elimination of ASA following the enteric-coated preparation reflects elimination that is rate-limited by absorption. 8 to the potential for erratic absorption patterns following enteric-coated ASA, 18 " 10 detectable plasma ASA levels are dependent on fortuitous blood collection times. This is exemplified in our study by the absence of ASA in all plasma samples of some subjects.…”

Aspirin’s Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses

“…The best-known salicylate is acetylsalicylic acid, commonly known as aspirin. In addition to its antiinflammatory, antipyretic and analgesic effects (5)(6)(7), prophylactic use of aspirin reduces the risk of heart attack, stroke and certain cancers (3,8,9). Aspirin's primary mechanism of action in mammals has been attributed to disruption of eicosanoid biosynthesis through irreversible inhibition via acetylation of cyclooxygenases (COX) 1 and 2, thereby altering the levels of prostaglandins, hormones that are involved in inflammation 4 Alessandro Preti, 4 Sang-Wook Park, Salicylic acid (SA) and its derivatives have been used for millennia to reduce pain, fever and inflammation.…”

Aspirin prolongs bleeding time in uremia by a mechanism distinct from platelet cyclooxygenase inhibition.

“…Thus it appears that ASA is completely absorbed in uremics, as reported for controls (22), and hydrolysis by intestinal and plasma esterases must account for its peculiar bioavailability.…”

“…Serum was assayed at a final dilution of 1:150 to 1:15,000. 5,000 dpm of [3H]TxB2, and sufficient specific rabbit antibodies to bind 40% ofthe tritiated compound were incubated [16][17][18][19][20][21][22][23][24] h at 4°C in a final volume of 1.5 ml in each assay tube. Anti-TxB2 was used at a final dilution of 1:250,000.…”