Plasma acetylsalicylate and salicylate and platelet cyclooxygenase activity following plain and enteric-coated aspirin.

Abstract

AC VS ANTI-PLATELET THERAPY IN

A Randomized, Quadruple Crossover Single-Blind Study on Immediate Action of Chewed and Unchewed Low-Dose Acetylsalicylic Acid Tablets in Healthy Volunteers

“…Ali et al have hypothesized that plasma ASA level, at least in the portal circulation, attains a bolus threshold required for maximum acetylation. 7 Our study supports this hypothesis.…”

“…These results are broadly consistent with previous reports. 7,22,31 Slow release, enteric-coated formulations may deliver ASA to the portal circulation at a slow enough rate to allow substantial deacetylation of aspirin during its first pass through the liver. Ali et al have hypothesized that plasma ASA level, at least in the portal circulation, attains a bolus threshold required for maximum acetylation.…”

“…The ASA-induced inhibition lasts for the life of the platelet, or about 7-10 days. [7][8] At the same time, inactivation of COX in vascular endothelial cells also prevents the synthesis of prostacyclin a substance that inhibits platelet aggregation.…”

“…The pharmacokinetic as well as pharmacological characteristics of enteric-coated, plain non-enteric-coated buffered ASA tablet and soluble ASA after normal ingestion have been clarified, 7,8,22,[25][26][27][28][29] but there has been no 6 direct comparison with the characteristics after ingestion of chewed low-dose ASA tablets. Therefore, the aim of the present study was to provide clinical evidence to support the recommendation of the Guidelines for the management of patients with acute myocardial infarction.…”

Spontaneous Resolution of Delayed Onset Large Subclavian Artery Pseudoaneurysm -Case Report-

“…9) Pseudoaneurysm often occurs in the arteries with a superficial course, with rather small calibers, and/or injury with a small needle. Stopping of aspirin administration, 1,13,15) change from unfractionated heparin to nafamostat mesilate, 12) and/or thrombogenicity of nonionic iodinated contrast medium 3) might promote aneurysmal thrombosis, but spontaneous resolution of unknown etiology is most likely. A period of Neurol Med Chir (Tokyo) 49, November, 2009…”