Kikuchi‐Fujimoto's Disease: An Easily Misdiagnosed Clinical Entity

Abstract

Kikuchi-Fujimoto's disease (KFD) or histiocytic necrotizing lymphadenitis is a self-limited cause of cervical lymphadenopathy. First described by Kikuchi and Fujimoto in 1972, its history dates back to the late 1960s. 1 At that time, the National Cancer Institute had organized the Lymphoma Task Force whose objective was to review pathology specimens for confirmation of diagnoses. 1 The task force identified 108 cases, some who had already started chemotherapy, that were misdiagnosed as lymphoma and actually represented "an unusual form of necrotizing lymphadenitis." 1 Reporting these findings in 1973, these patients were identified as having KFD. Subsequent cases surfaced throughout the world's literature, all describing a clinical entity that had been mistaken for lymphoma, lupus, and an assortment of infectious diseases. 1,2 We present a patient with KFD to further illustrate the varied clinical presentation of this disease. CASE REPORTA 26-year-old white women presented with a 3-day history of a painful neck mass, fevers, and myalgias. She had no medical history, and she was healthy until 3 days before presentation when she began feeling malaise and noted a right sided neck mass. On physical examination, the patient was vomiting and had a temperature of 40°C. She had a 5 × 7 cm right cervical mass that was tender to palpation, erythematous, and mobile. There was no ulceration or drainage. Her skin was warm to palpation, but there was no rash, petechia, or purpura. She had no hepatosplenomegaly and no other lymphadenopathy. Her white blood cell count was 5.2 with a normal differential.Please send your change of address notification at least six weeks before your move to ensure continued service. We regret we cannot guarantee replacement of issues missed due to late notification.

Evaluation of 44 Kikuchi-Fujimoto Disease Cases Reported from Turkey Between 2000-2010 with Pooled Analysis Method

“…tarafından yapılan çalışmada, İİAB ile yanlış tanı oranı %40 olarak belirtilmiş ve en çok non-Hodgkin lenfomalar (NHL) ile karışma riskinin bulunduğu bildirilmiş-tir. 47 Sunulan çalışmada da yedi olguya öncelikle İİAB yapılmış ancak sonuçlar tanı için yeterli olmamıştır. KFH'de eksize edilen lenf bezlerinin histopatolojik incelemesinde lenf bezleri makroskobik olarak normal veya büyümüş olabilir.…”

Bir nekrotizan lenfadenitis nedeni; Kikuchi-Fujimoto hastalığı A cause ofnecrotizing lymphadenitis Kikuchi Fujimoto Disease

“…Olguların çok büyük kısmında lenfadenopati tek bir böl-gede saptanır iken nadir de olsa yaygın lenfadenopati rapor edilmiştir (4,5). Hepatosplenomegali sıktır (16). Ancak ekstranodal tutulum literatürde nadir olarak rapor edilmiş-tir (16,14).…”

Kikuchi’s disease: an important cause of cervical lymphadenopathy

“…7 The treatment consequently is symptomatic with non-steroidal anti-inflammatory drugs. 12 In more complicated cases, such as patients with recurrent episodes or prolonged symptoms, more aggressive management with systemic steroids has been required. 13 Hydroxychloroquine has also shown some benefit in treating the disease.…”