Kikuchi’s disease: an important cause of cervical lymphadenopathy

Qadri, Farzana; Atkin, G E; Thomas, D; Das, Saroj

doi:10.7861/clinmedicine.7-1-82

Cited by 17 publications

(23 citation statements)

References 20 publications

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“…The disease usually manifests in the fi rst decade of life with massive and painless cervical lymphadenopathy, often accompanied by fever, malaise, weight loss, neutrophilic leukocytosis, elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. Kikuchi-Fujimoto disease (histocytic necrotizing lymphadenitis) is a benign cause of lymph node enlargement, usually in the posterior cervical triangle [ 9 ]. The condition primarily affects young females.…”

Section: Etiologymentioning

confidence: 99%

“…Fever, nausea, weight loss, night sweats, arthralgia, myalgia, or hepatosplenomegaly might be present. The etiology of Kikuchi-Fujimoto disease is unknown, but a viral cause has been implicated [ 9 ]. Classical pathologic fi ndings include patchy areas of necrosis in the cortical and paracortical areas of the enlarged lymph nodes and a histiocytic infi ltrate [ 9 ].…”

Section: Etiologymentioning

confidence: 99%

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Cervical lymphadenitis: Etiology, diagnosis, and management

Leung

Davies²

2009

Curr Infect Dis Rep

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Cervical lymphadenopathy is a common problem in children. The condition most commonly represents a transient response to a benign local or generalized infection. Acute bilateral cervical lymphadenitis is usually caused by a viral upper respiratory tract infection or streptococcal pharyngitis. Acute unilateral cervical lymphadenitis is caused by streptococcal or staphylococcal infection in 40% to 80% of cases. Common causes of subacute or chronic lymphadenitis include cat-scratch disease and mycobacterial infection. Generalized lymphadenopathy is often caused by a viral infection, and less frequently by malignancies, collagen vascular diseases, and medications. Laboratory tests are not necessary in most children with cervical lymphadenopathy. Most cases of cervical lymphadenitis are self-limited and require no treatment. The treatment of acute bacterial cervical lymphadenitis without a known primary source should provide adequate coverage for both Staphylococcus aureus and Streptococcus pyogenes.

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Section: Etiologymentioning

confidence: 99%

Section: Etiologymentioning

confidence: 99%

Cervical lymphadenitis: Etiology, diagnosis, and management

Leung

Davies²

2009

Curr Infect Dis Rep

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“…Additional findings may include increased lactate dehydrogenase, leukopenia, and elevated serum transaminases 28. Approximately 25–58% of patients experience leukopenia and 2–5% of patients experience leukocytosis 29. Elevations in erythrocyte sedimentation rate have also been noted 26.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

Deaver

Naghashpour

Sokol

2013

Mediterr J Hematol Infect Dis

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Kikuchi-Fujimoto Disease (KFD), also known as histiocytic lymphadenitis, is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue. There is a higher incidence of KFD in women aged 20–35 years and in Asian populations. A PubMed search revealed 590 articles that described KFD. Of these, 22 cases have been fully described in the United States. Ten of the 22 (45%) patients were male and 12 (55%) were female, with 20% Caucasian, 20% Asian American, and the remaining 60% of other ethnic backgrounds. In this study, we describe an additional 3 cases of KFD and discuss the diagnosis, pathology, and management of KFD.

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“…Several infective agents such as EBV, parvovirus B 19 and HHV-6 have been thought to be causative although no relationship or link has been established. 5 Histological similarity seen between SLE and Kikuchi Fujimoto disease (KFD) led Dorfman and Berry to suggest that KFD could be an attenuated form of SLE. 6 Another hypothesis proposed that KFD might be a self-limiting SLE-like auto immune reaction to viral infected transformed lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi Fujimoto lymphadenitis- an uncommon entity in the surgical outpatients: a case report

et al. 2017

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Kikuchi Fujimoto lymphadenitis is a benign self-limiting disease with subacute necrotizing lymphadenopathy of unknown cause. The clinical, histopathological and immunohistochemical features point to viral etiology hence delaying diagnosis commonly. Clinicians and pathologists awareness of this disorder may prevent misdiagnosis and inappropriate treatment. We describe here a case of a young woman admitted under our care with fever and cervical lymphadenopathy. Cervical lymph node biopsy revealed the rare clinical disorder of Kikuchi Fujimoto lymphadenitis which is not thought of as a primary cause of lymphadenopathy in the Indian subcontinent where tuberculosis is widely prevalent.

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Kikuchi’s disease: an important cause of cervical lymphadenopathy

Cited by 17 publications

References 20 publications

Cervical lymphadenitis: Etiology, diagnosis, and management

Cervical lymphadenitis: Etiology, diagnosis, and management

Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

Kikuchi Fujimoto lymphadenitis- an uncommon entity in the surgical outpatients: a case report

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