Kidney Diseases in the Elderly

So, Sarah; Stevenson, Jessica; Lee, Vincent

doi:10.1007/978-3-319-96998-5_16

Cited by 2 publications

(2 citation statements)

References 135 publications

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“…Phosphatopathies can generally be observed in patients with kidney diseases (29). Kidney diseases are associated with a progressive reduction in kidney function in older adults (30). Over 26 American people (13% of the entire population of the US) have kidney diseases (31).…”

Section: The Effect Of Aging On Klothomentioning

confidence: 99%

Effect of Exercise Training and Aging on Klotho Signaling in the Heart

Baghaiee

Barzegari

Zali

et al. 2019

J Clin Res Paramed Sci

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Aging, if accompanied by a sedentary lifestyle, can result in different diseases including cardiovascular diseases. Klotho, a protein found in the kidneys and other tissues of the body, is influenced by age and level of physical activity. In this paper, using 66 papers published in PubMed and SID between 1997 and 2018, we examined the mechanism of action of Klotho on cardiac hypertrophy under senescence conditions. Studies have shown that aging results in the development of oxidative stress as well as increased MAPK and TRPC6. These factors push the heart towards pathological hypertrophy, where deficiency of Klotho accelerates this trend. Nevertheless, exercise training causes enhanced Klotho levels. This protein is able to inhibit oxidative stress as an upstream factor in the activity of MAPK and TRPC6.

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Section: The Effect Of Aging On Klothomentioning

confidence: 99%

Effect of Exercise Training and Aging on Klotho Signaling in the Heart

Baghaiee

Barzegari

Zali

et al. 2019

J Clin Res Paramed Sci

View full text Add to dashboard Cite

show abstract

“…Hypertension, diabetes, long-term inflammation and urological diseases (such as prostate hypertrophy and urinary tract stones) are not only common chronic diseases in the elderly, but also common causes of deterioration of renal function, and contribute to CKD progression 2 3. In addition, the elderly are a population at high risk for acute kidney injury because of physiological age-related changes or polypharmacy and drug toxicity,2 4 and probably develop CKD in the context of incomplete repair of renal tubular epithelial cells, glomerulosclerosis, ischaemia-reperfusion injury and fibrosis 5 6…”

Section: Introductionmentioning

confidence: 99%

Association between renal function and cardiovascular mortality: a retrospective cohort study of elderly from health check-up

et al. 2021

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ObjectivesThis study aimed to investigate the relationship between cardiovascular mortality in elderly Asians and decline in renal function.DesignA retrospective cohort study.SettingCommunity-based health examination database from Taipei city.ParticipantsAt the beginning, the database included 315 045 health check-up visits of 97 803 elderly persons aged ≥65 years old from 2005 to 2012. After excluding missing values and outliers, there were 64 732 elderly persons with at least two visits retained for further analyses.Primary outcome measuresKidney function indicators include estimated glomerular filtration rate (eGFR) and urine protein, and rapid decline in eGFR was defined as slope ≤ −5 mL/min/1.73 m2 per year. The endpoint outcome was defined as the cardiovascular deaths registered in the death registry encoded by the International Classification of Diseases. We applied a Cox proportional hazards model to analyse the association between renal function and cardiovascular mortality.ResultsIn this study, we found 1264 elderly persons died from cardiovascular diseases, for whom the data included 4055 previous health check-up visits. We observed significant and independent associations of eGFR <60 mL/min/1.73 m2 (HR (95% CI) of 60>eGFR≥45 and eGFR<45 in males: 2.85 (1.33 to 6.09) and 3.98 (1.84 to 8.61); in females: 3.66 (1.32 to 10.15) and 6.77 (2.41 to 18.99)), positive proteinuria (HR (95% CI) of +/−, +,++ and +++, ++++ in males: 1.51 (1.29 to 1.78) and 2.31 (1.51 to 3.53); in females: 1.93 (1.54 to 2.42) and 4.23 (2.34 to 7.65)) and rapid decline in eGFR (HR (95% CI) in males: 3.24 (2.73 to 3.85); in females: 2.83 (2.20 to 3.64) with higher risk of cardiovascular mortality. The joint effect of increased concentration of urine protein and reduced eGFR was associated with a higher risk of cardiovascular mortality.ConclusionsRenal function and rapid decline in renal function are independent risk factors for cardiovascular mortality in the elderly.

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Kidney Diseases in the Elderly

Cited by 2 publications

References 135 publications

Effect of Exercise Training and Aging on Klotho Signaling in the Heart

Effect of Exercise Training and Aging on Klotho Signaling in the Heart

Association between renal function and cardiovascular mortality: a retrospective cohort study of elderly from health check-up

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