Ki67 expression in breast cancer

Abstract

Objectives:To evaluate Ki67 immunoexpression pattern in Saudi breast cancer (BC) patients and investigate any possible predictive or prognostic value for Ki67.Methods:This is a retrospective study designed to quantitatively assess the Ki67 proliferative index (PI) in retrieved paraffin blocks of 115 Saudi BC patients diagnosed between January 2005 and March 2015 at the Department of Pathology, King Fahd Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia. The Ki67 PI was correlated with individual and combined immunoprofile data of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu) with their clinicopathological parameters.Results:Ki67 immunoreactivity was highly expressed (>25% of the tumor cells were positive) in 85 (73.9%) patients. The Ki67 PI was significantly associated with poor prognostic clinicopathological parameters including old age (p<0.02), high tumor grade (p<0.01), lymph node metastasis (p<0.001), and Her-2/neu positivity (p<0.009). However, the association with ER positivity, PR positivity, tumor size, and lymphovascular invasion were not statistically significant. The Ki67 PI was significantly associated with BC molecular subtypes that were Her2/neu positive (luminal B and HER-2) subtypes compared with the Her2/neu negative (luminal A) subtype (p<0.04).Conclusion:The Ki67 PI is significantly higher in Saudi BC patients comparing with the reported literature. Ki67 PI was highest in the HER-2 and luminal-B molecular subtypes. Along with other prognostic indicators, Ki67 PI may be useful in predicting prognosis and management of Saudi BC patients.

Comparative study of Her-2, p53, Ki-67 expression and clinicopathological characteristics of breast cancer in a cohort of northern China female patients

“…37 Ki-67 is a nuclear protein that is commonly used for the detection and quantification of proliferating cells because an increase in its expression is associated with cell growth. 27 Consistent with the observations of others, 6,37,[50][51][52][53] our observation that Ki-67 positive led breast carcinoma progress to higher histological grade in breast patients implicated that Ki-67 high expression promoted tumor growth in breast cancer patients. 50 Our observation that both PR positive and ER positive connected with a slower histological progress in breast cancer, which was in agreement with the observations by Shapochka et al, 37 suggests that PR and ER might have an inhibitive role in breast cancers.…”

“…32,58 The connection of PR positive and a slower histological progress in breast cancer observed in this study might also be a result of a negative association between PR and Her-2 positive in breast cancers 56 caused by the loss of PR protein due to Her-2 overexpression through the PI3K/Akt signaling pathway. 59 Relationship of Her-2, PR, ER, Ki-67 and p53 in signaling transduction pathways In this study, it was found that Her-2 overexpression was negatively connected with PR and ER expression and positively connected with Ki-67 positive and p53 positive, which was consistent with previous reports 30,32,37,44,46,49,53,59,60 This suggests that there might be some relationship among Her-2 and these genes in signal transduction pathways. Through MAPK and PI3K signaling pathways, Her-2 prevents apoptosis and promotes cell proliferation.…”

Prediction model of lymphovascular invasion based on clinicopathological factors in Chinese patients with invasive breast cancer

“…We found that HER-2, Ki67, and tumor size were statistically significantly associated with LVI, whereas the age of diagnosis, histological grade, and statuses of ER, PR, EGFR, VEGF, E-cadherin, and P53 were not related to LVI. However, Elkablawy et al [ 9 ] reported that Ki67 expression was not associated with LVI. Two possible factors existed: first, the race and region of the patients were not the same; second, the criterion of Ki67 high expression was different.…”

Predictors of lymphovascular invasion identified from pathological factors in Chinese patients with breast cancer

“…Ki-67 expression is a predictor of breast cancer and has been identified as an independent prognostic factor of DFS in invasive breast cancer [ 13 ]. High Ki-67 expression is the result of rapid tumor proliferation, which results in a poor prognosis [ 14 ]. In the current study, patients with high Ki-67 expression had significantly high rates of LVI compared to those with low Ki-67 expression.…”

“…In addition, a multivariate analysis showed that high Ki-67 expression is a risk factor for LVI (OR=1.785). However, Mohamed et al reported that Ki-67 expression was not associated with LVI [ 14 ]. Two primary reasons likely explain this difference: First, the races and regions of the patients were different; second, the criterion of high Ki-67 expression was different.…”