Comparative study of Her-2, p53, Ki-67 expression and clinicopathological characteristics of breast cancer in a cohort of northern China female patients

Li, Ding; Zhang, Zijin; Xu, Yan; Zhang, Yongqiang

doi:10.1080/21655979.2016.1235101

Cited by 19 publications

(17 citation statements)

References 60 publications

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“…A statistically significant negative correlation was also found between PR and p53 expression which is in concordance with the studies done by Friedrichs et al, 22 Jacquemier et al, 37 Neharika et al 20 Shoukouh et al 8 and Ranade et al 38 However, Piplani et al 19 and Al-Joudi et al 33 did not find any significant association between the two. However, no significant correlation was seen between Her2/neu and p53 expression, which is similar to Abdollahi et al 15 and S Han Jeong et al 41 In contrast Patnayak et al, 5 Rashed et al, 34 L Ding et al 44 and Neharika et al 20 reported a significant positive association between Her2/neu expression and p53 expression. Coexistence of Her2/neu overexpression and p53 protein accumulation has been suggested to be a strong prognostic molecular marker in breast cancer.…”

Section: Discussionsupporting

confidence: 72%

Evaluation of p53 in breast cancer and its correlation with various histological prognostic factors

Arora¹,

Khandelwal²,

Pant³

2020

IJPO

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Carcinoma of the breast is the most common non-skin malignancy in women. The p53 gene is one of the most commonly mutated genes described in human neoplasia. Mutant p53 protein has greater stability and longer half time than the wild type protein that can be detected by Immunohistochemistry. This study was conducted to evaluate the expression of p53 in breast carcinoma and its correlation with various histological prognostic markers to determine its significance as a prognostic marker in breast cancer. The prospective study included 52 modified radical mastectomy specimens diagnosed as breast cancer in the Department of Pathology at SRMSIMS, Bareilly between November 2016 and April 2018. Routine H&E staining and immunohistochemical analysis for ER, PR, Her2/neu and P53 was carried out in all the cases. Majority of the cases belonged to the age group 30-39 years and the most common cancer type was infiltrating ductal carcinoma. Significant correlation of p53 was observed with ER and PR expression, however no significant correlation could be found with tumor type, grade, size, type of margin, necrosis, stromal response, lymphovascular invasion, lymph node status and Her2/neu status.P53 was found to have a significant inverse correlation with ER and PR expression only. The results do not resolve whether detectable p53 protein expression represents a random product of dedifferentiation or an important feature of the malignant phenotype, playing a key role in tumor behavior.

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Section: Discussionsupporting

confidence: 72%

Evaluation of p53 in breast cancer and its correlation with various histological prognostic factors

Arora¹,

Khandelwal²,

Pant³

2020

IJPO

View full text Add to dashboard Cite

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“…Similarly, the results of Cox regression analysis showed that PR was also not an indicator of survival and prognosis of BC, which may had a relationship between a large data missing. In addition, Ding L et al found that BC with HER2 and KI-67 overexpression had higher lymph node metastasis rate and higher AJCC tumor stage [42,43] , which was the same as our researches. In this study, HER2 positive were 55.49% and 9.46% in southern China and SEER cohort respectively (P = 0.000), which was consistent with the literature that BC cells from young patients are more likely to show HER2 positive expression [34] .…”

Section: Discussionsupporting

confidence: 89%

The Comparison of Breast Cancer in Southern China and America: A Multicentre Study in China Versus SEER Database

Niu

Zhang

Chen

et al. 2021

Preprint

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Background and Objective: There are different characteristics of BC in developing countries and developed countries. We intend to study the factors which influence the survival and prognosis of BC between southern China and the United States. Methods: To study the two groups BC patients in southern China from 2001 to 2016 and SEER database from 1975 to 2016. To register, collect and analyze the clinicopathological features and treatment information. Results: Our study found that there are significant differences in tumor size, positive lymph node status and KI-67 between southern China and SEER cohort (P<0.000). Conclusions: The age, tumor size, positive-node and KI-67 may cause the difference of morbidity and mortality of BC patients in southern China and SEER cohort.

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Section: Discussionsupporting

confidence: 89%

The Characteristics Comparison of Breast Cancer Patients in Southern China and America: A Multicentre Study in China Versus SEER Database

Niu¹,

Zhang²,

Chen³

et al. 2020

Preprint

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Background and Objective: The morbidity and mortality of breast cancer are increasing in recent years, which had become the second main cause of cancer death in women. However, there are different characteristics of breast cancer in developing countries and developed countries. What’s more, it has not reported the comparison of breast cancer between southern China and the United States. We intend to compare the age, different stages and grades of tumor and treatment methods, in order to study the factors which influence the survival and prognosis of breast cancer patients. Methods: To study the two groups which have been diagnosed with breast cancer in southern China from 2001 to 2016 and SEER database from 1975 to 2016. To register, collect and analyze the clinicopathological features and treatment information. To follow up the patients who have been diagnosed before 2016. Kaplan-Meier method was used to evaluate disease-free survival (DFS) and overall survival (OS). Results: Young breast cancer patients accounted for 19.8% and 6.14% respectively in southern China and SEER cohort. The early diagnostic rate of breast cancer is high in southern China, but still lower than SEER cohort. Our study found that there are significant differences in tumor size and positive lymph node status between southern China and SEER cohort (P=0.000), which notably affect the OS of breast cancer patients (P=0.018 and P=0.000). Furthermore, KI-67 is also an important prognostic factor of breast cancer patients in southern China, which also affect the OS of patients (P=0.034). In treatment, there are also significant differences between the two regions. In southern China, there are 4.91% of breast cancer patients performed breast conserving surgery and 95.09% patients performed mastectomy. But in SEER cohort, there are only 4.91% patients preformed breast surgery. Conclusions: The age, tumor size, positive-node and KI-67 may cause the difference of morbidity and mortality of breast cancer patients in southern China and SEER cohort. Overall, the prognosis of breast cancer patients in SEER cohort is better than southern China.

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Comparative study of Her-2, p53, Ki-67 expression and clinicopathological characteristics of breast cancer in a cohort of northern China female patients

Cited by 19 publications

References 60 publications

Evaluation of p53 in breast cancer and its correlation with various histological prognostic factors

Evaluation of p53 in breast cancer and its correlation with various histological prognostic factors

The Comparison of Breast Cancer in Southern China and America: A Multicentre Study in China Versus SEER Database

The Characteristics Comparison of Breast Cancer Patients in Southern China and America: A Multicentre Study in China Versus SEER Database

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