Ki-67 protein as a tumour proliferation marker

Menon, Sunil Sankunny; Guruvayoorappan, Chandrasekharan; Sakthivel, Kunnathur Murugesan; Rasmi, Rajan Radha

doi:10.1016/j.cca.2019.01.011

Cited by 254 publications

(191 citation statements)

References 71 publications

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“…Tumor mitotic figure is one of the independent prognostic factors [2,20,21]. Ki-67 is a proliferation marker for tumors and has been used for tumor staging, poorly differentiated malignancies [22]. Li et al [23] reported that the Ki-67 index was positively correlated with mitotic counts.…”

Section: Discussionmentioning

confidence: 99%

Risk stratification in GIST: shape quantification with CT is a predictive factor

Wei

Liang

et al. 2020

Eur Radiol

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Background Tumor shape is strongly associated with some tumor's genomic subtypes and patient outcomes. Our purpose is to find the relationship between risk stratification and the shape of GISTs. Methods A total of 101 patients with primary GISTs were confirmed by pathology and immunohistochemistry and underwent enhanced CT examination. All lesions' pathologic sizes were 1 to 10 cm. Points A and B were the extremities of the longest diameter (LD) of the tumor and points C and D the extremities of the small axis, which was the longest diameter perpendicular to AB. The four angles of the quadrangle ABCD were measured and each angle named by its summit (A, B, C, D). For regular lesions, we took angles A and B as big angle (BiA) and small angle (SmA). For irregular lesions, we compared A/B ratio and D/C ratio and selected the larger ratio for analysis. The chi-square test, t test, ROC analysis, and hierarchical or binary logistic regression analysis were used to analyze the data. Results The BiA/SmA ratio was an independent predictor for risk level of GISTs (p = 0.019). With threshold of BiA at 90.5°, BiA/SmA ratio at 1.35 and LD at 6.15 cm, the sensitivities for high-risk GISTs were 82.4%, 85.3%, and 83.8%, respectively; the specificities were 87.1%, 71%, and 77.4%, respectively; and the AUCs were 0.852, 0.818, and 0.844, respectively. LD could not effectively distinguish between intermediate-risk and high-risk GISTs, but BiA could (p < 0.05). Shape and Ki-67 were independent predictors of the mitotic value (p = 0.036 and p < 0.001, respectively), and the accuracy was 87.8%. Conclusions Quantifying tumor shape has better predictive efficacy than LD in predicting the risk level and mitotic value of GISTs, especially for high-risk grading and mitotic value > 5/50HPF. Key Points • The BiA/SmA ratio was an independent predictor affecting the risk level of GISTs. LD could not effectively distinguish between intermediate-risk and high-risk GISTs, but BiA could. • Shape and Ki-67 were independent predictors of the mitotic value.• The method for quantifying the tumor shape has better predictive efficacy than LD in predicting the risk level and mitotic value of GISTs.

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Section: Discussionmentioning

confidence: 99%

Risk stratification in GIST: shape quantification with CT is a predictive factor

Wei

Liang

et al. 2020

Eur Radiol

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“…The cell-cycle-associated Ki-67 antigen is a well-known proliferative index used in several human cancers (Menon et al 2019). Ki-67 labeling index is mostly reported as the percent of positively stained cells and a cut-off value >5% of tumor nuclei stained is commonly accepted as a high proliferative index.…”

Section: Ki-67mentioning

confidence: 99%

Atypical parathyroid adenomas: challenging lesions in the differential diagnosis of endocrine tumors

Cetani

Marcocci

Torregrossa

et al. 2019

Endocrine-Related Cancer

110

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Atypical parathyroid adenomas represent a group of intermediate form of parathyroid neoplasms of uncertain malignant potential which show some atypical histological features that represent a challenge for the differential diagnosis with parathyroid carcinomas. They may occur as sporadic or as a part of hereditary syndromes. The molecular signature of these neoplasms is still unknown and the germline CDC73 mutations appears to be the most common anomaly in this setting suggesting that these cases might represent variants of the hyperparathyroidism-jaw tumor syndrome. The identification of markers predicting the outcome is of great importance to guide an adequate postoperative monitoring and, the same time, relieve of the anxiety of relatively strict monitoring patients not at risk. This review will summarize the current knowledge of the clinical, biochemical, molecular and histological profile of atypical parathyroid adenomas.

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“…The percentage of tumor cells that show positive Ki-67 expression (determined by IHC analysis) is associated with patient outcomes, and a high Ki-67 index is usually associated with poor prognosis in patients with lung, bladder, breast, and cervical cancer; and lymphoma. 15 The Ki-67 expression rate was 8% in our patient. There is a lack of consensus regarding the utility of the Ki-67 index as a prognostic marker for SPT; however, Yang et al 16 reported that a Ki-67 index >4% may indicate poor prognosis in patients with SPT.…”

Section: Discussionmentioning

confidence: 47%

An Unusual Presentation of a Solid Pseudopapillary Tumor of the Pancreas Mimicking Adenocarcinoma

2020

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Solid pseudopapillary tumors of the pancreas are rare and typically occur in young women. Compared with pancreatic adenocarcinoma, solid pseudopapillary tumors are characterized by notable indolent biological behavior associated with a favorable prognosis. Despite their large size, these tumors rarely metastasize. Even in cases of hepatic metastasis, most lesions are usually solitary in distribution and are amenable to resection. We report a case of a 55-year-old man with a small solid pseudopapillary tumor (≤3-cm diameter) mimicking a pancreatic adenocarcinoma, with multiple hepatic metastases. The diagnosis was confirmed by endoscopic ultrasoundguided fine-needle biopsy using a 22-G core needle. Unfortunately, rapid tumor progression led to patient mortality 5 months after diagnosis. To our knowledge, this is the first case report that describes a small solid pseudopapillary tumor of the pancreas with multiple hepatic metastasis and poor prognosis in a patient who was diagnosed with this condition at the time of initial diagnosis. Clin Endosc Nov 22. [Epub ahead of print]

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Ki-67 protein as a tumour proliferation marker

Cited by 254 publications

References 71 publications

Risk stratification in GIST: shape quantification with CT is a predictive factor

Risk stratification in GIST: shape quantification with CT is a predictive factor

Atypical parathyroid adenomas: challenging lesions in the differential diagnosis of endocrine tumors

An Unusual Presentation of a Solid Pseudopapillary Tumor of the Pancreas Mimicking Adenocarcinoma

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