Background: The involvement of significant others is an objective in suicide prevention and there is a need for development of interventions for this group. The aim of this open naturalistic study was to evaluate the feasibility and the preliminary efficacy of Family Connections (FC) for significant others of suicidal patients, a nine-week manualized skills training program based on dialectical behavior therapy (DBT) in a clinical context.Methods: The intervention program aims to enhance the knowledge of symptoms and behaviors connected with attempted suicide. Furthermore it introduces stress-coping strategies and emotion regulation skills. Out of 132 participants in total, 104 (79%) completed the program. Included in the analysis were the 86 (65%) participants who completed the program and also had both pre- and post-intervention assessments. The Burden Assessment scale (BAS), the Questions About Family Members scale (QAFM), and the Five Facet Mindfulness Questionnaire (FFMQ), were used to assess perceived burden, relationship climate and five facets of mindfulness respectively. Results: The results showed a significant reduction in perceived burden, measured with BAS and a significant change in the mindfulness scale FFMQ subscale Acting with Awareness, which indicates an enhanced ability to be present in the moment. None of the four subscales in QAFM showed significant changes between the pre- and post-intervention assessments.Conclusions: The results support the feasibility and potential value of the implementation of an intervention for significant others of suicidal patients in psychiatric care. Randomized controlled studies are needed to generate further evidence.