Ketogluconic Acids from Glucose BACTERIAL PRODUCTION

Stubbs, J. J.; Lockwood, Lewis B.; Roe, Edward T.; Tabenkin, B.; Ward, George E.

doi:10.1021/ie50372a024

Cited by 74 publications

(19 citation statements)

References 11 publications

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“…The ability of P. aeruginosa to oxidize potassium gluconate to 2-ketogluconate was implied by the work of Norris & Campbell (1949) and Stubbs et al (1940). It has been confirmed in the present investigation and shown to be of taxonomic value when used as a diagnostic characteristic along with ability to grow at 42' and to produce slime from potassium gluconate.…”

Section: Oxidation Of Potassium Gluconatesupporting

confidence: 74%

“…The strain with which they worked is included among the strains studied in this investigation. Stubbs, Lockwood, Roe, Tabenkin & Ward (1940) demonstrated the ability of an organism later identified as a pseudomonad to produce 2-ketogluconic acid from calcium gluconate. Inasmuch as gluconic acid does not reduce Benedict's reagent and yet may be oxidized to 2-ketogluconic acid which does reduce it, the advantage of gluconic acid as the carbon source in studying the oxidative metabolism of these organisms is obvious.…”

Section: Oxidation Of Potassium Gluconatementioning

confidence: 99%

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Pseudomonas aeruginosa---its Characterization and Identification

Haynes

1951

Journal of General Microbiology

167

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Section: Oxidation Of Potassium Gluconatesupporting

confidence: 74%

Section: Oxidation Of Potassium Gluconatementioning

confidence: 99%

Pseudomonas aeruginosa---its Characterization and Identification

Haynes

1951

Journal of General Microbiology

167

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“…Stubbs et al [42] calculated a productivity of 3.2 gL À1 h À1 . Starting with 120 gL À1 glucose, concentration-dependent inhibition was observed in batch fermentations.…”

Section: -Oxo-d-gluconic Acidmentioning

confidence: 99%

White biotechnology for green chemistry: fermentative 2-oxocarboxylic acids as novel building blocks for subsequent chemical syntheses

Stottmeister

Aurich

Wilde

et al. 2005

J IND MICROBIOL BIOTECHNOL

106

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Functionalized compounds, which are difficult to produce by classical chemical synthesis, are of special interest as biotechnologically available targets. They represent useful building blocks for subsequent organic syntheses, wherein they can undergo stereoselective or regioselective reactions. "White Biotechnology" (as defined by the European Chemical Industry [ http://www.europabio.org/white_biotech.htm ], as part of a sustainable "Green Chemistry,") supports new applications of chemicals produced via biotechnology. Environmental aspects of this interdisciplinary combination include: Use of renewable feedstock Optimization of biotechnological processes by means of: New "high performance" microorganisms On-line measurement of substrates and products in bioreactors Alternative product isolation, resulting in higher yields, and lower energy demand In this overview we describe biotechnologically produced pyruvic, 2-oxopentaric and 2-oxohexaric acids as promising new building blocks for synthetic chemistry. In the first part, the microbial formation of 2-oxocarboxylic acids (2-OCAs) in general, and optimization of the fermentation steps required to form pyruvic acid, 2-oxoglutaric acid, and 2-oxo-D-gluconic acid are described, highlighting the fundamental advantages in comparison to chemical syntheses. In the second part, a set of chemical formula schemes demonstrate that 2-OCAs are applicable as building blocks in the chemical synthesis of, e.g., hydrophilic triazines, spiro-connected heterocycles, benzotriazines, and pyranoic amino acids. Finally, some perspectives are discussed.

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“…In the same way, submerged fermentation of glucose to gluconic acid by ''A. niger 3'' in rotating aluminium drums was also carried out using corn steep liquor [53] as was the bacterial fermentation of glucose to 5-ketogluconic acid (Acetobacter suboxydans) and 2-ketogluconic acid with an unnamed bacterium [48].…”

Section: Submerged Fermentation and Use Of Corn Steep Liquormentioning

confidence: 99%

Different roads to discovery; Prontosil (hence sulfa drugs) and penicillin (hence β-lactams)

Bentley

2009

J Ind Microbiol Biotechnol

109

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The important chemotherapeutic agents, Prontosil and pentenylpenicillin (penicillin F), were investigated initially by two men, Domagk and Fleming, who had been influenced by the horrendous wound infections of World War I. The very different pathways leading to their development and to that of the successor antibacterials (sulfa drugs, further penicillins, semi-synthetic penicillins), including the role played by patents, are discussed.

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Ketogluconic Acids from Glucose BACTERIAL PRODUCTION

Cited by 74 publications

References 11 publications

Pseudomonas aeruginosa---its Characterization and Identification

Pseudomonas aeruginosa---its Characterization and Identification

White biotechnology for green chemistry: fermentative 2-oxocarboxylic acids as novel building blocks for subsequent chemical syntheses

Different roads to discovery; Prontosil (hence sulfa drugs) and penicillin (hence β-lactams)

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