“…Ketamine combinations with sedatives, tranquilizers and analgesics are also used as balanced anesthetics and restraining agents in wild animals (Carter & Story, 2013;Coetzee, 2013;Short, 1992). Further, ketamine have anticonvulsant activity in mice (Tricklebank, Singh, Oles, Preston, & Iversen, 1989) and chicks (Reder, Trapp, & Troutman, 1980) Silymarin (milk thistle), a medical herb belonging to the Asteraceae family (Ottai& Abdel-Moniem, 2006), is home Southern Europe, Southern Russia, Asia Minor and Northern Africa (Abenavoli, Capasso, Milic, & Capasso, 2010).Silymarin is mixture of silibinin A and B (silybin A and B), silydianin and silychristin. Other flavonolignans include isosilybin A and B, isosilychristin and taxifolin (Ottai & Abdel-Moniem, 2006;Stolf, Cardoso, & Acco, 2017).…”