Ketamine Suppression of Chemically Induced Convulsions in the Two-Day-Old White Leghorn Cockerel

Reder, B.; Trapp, Larry D.; Troutman, Kenneth C.

doi:10.1213/00000539-198006000-00003

Cited by 18 publications

(2 citation statements)

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“…MK-801 is not the only NMDA antagonist which has anticonvulsant actions (Meldrum, 1985), and indeed it has been reported that ketamine is an anticonvulsant (Reder et al, 1980). Whether or not an interaction of these drugs with thalamic synaptic NMDA receptors is of major importance in determing anticonvulsant action remains to be elucidated, but it does seem possible that such an interaction could be a contributory factor.…”

Section: Discussionmentioning

confidence: 99%

Antagonism of N‐methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK‐801

Salt¹,

Wilson²,

Prasad³

1988

British J Pharmacology

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Extracellular single neurone recordings were made in the ventrobasal thalamus of urethaneanaesthetized rats. Iontophoretically and intravenously administered ketamine and MK‐801 were found to be selective antagonists of responses of neurones to iontophoretically applied N‐methylaspartate. Both antagonists, administered in N‐methylaspartate‐selective quantities, reduced the synaptic responses of ventrobasal thalamus neurones to a two‐second air jet directed at the peripheral receptive field.

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Section: Discussionmentioning

confidence: 99%

Antagonism of N‐methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK‐801

Salt¹,

Wilson²,

Prasad³

1988

British J Pharmacology

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“…Ketamine combinations with sedatives, tranquilizers and analgesics are also used as balanced anesthetics and restraining agents in wild animals (Carter & Story, 2013;Coetzee, 2013;Short, 1992). Further, ketamine have anticonvulsant activity in mice (Tricklebank, Singh, Oles, Preston, & Iversen, 1989) and chicks (Reder, Trapp, & Troutman, 1980) Silymarin (milk thistle), a medical herb belonging to the Asteraceae family (Ottai& Abdel-Moniem, 2006), is home Southern Europe, Southern Russia, Asia Minor and Northern Africa (Abenavoli, Capasso, Milic, & Capasso, 2010).Silymarin is mixture of silibinin A and B (silybin A and B), silydianin and silychristin. Other flavonolignans include isosilybin A and B, isosilychristin and taxifolin (Ottai & Abdel-Moniem, 2006;Stolf, Cardoso, & Acco, 2017).…”

Section: Introductionmentioning

confidence: 99%

Isobolographic analysis of analgesic interactions of silymarin with ketamine in mice

Naser¹,

Albadrany²,

Shaaban³

2020

J Hellenic Vet Med Soc

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The present study was undertaken to explore the analgesic effect of silymarin and ketamine alone or in combination in mice. Analgesia was measured by using a hot plate and the writhing test. The up-and-down method was used to determine the median effective analgesic dosages (ED50s) of silymarin and ketamine administered intraperitoneally (ip) either alone or together. The ED50s of both drugs were analyzed isobolographically to determine the type of pharmacological interaction between them. The analgesic ED50s for silymarin and ketamine in mice were 57.22 and 1.96 mg/kg, ip, respectively. Concomitant administration of the silymarin and ketamine at fixed ration (0.5:0.5) of their individual ED50s was 38.4 mg/kg and 1.28 mg/kg, ip, respectively. Silymarin and ketamine at fixed ration (1:1) of their individual ED50s were 47.54 mg/kg and 1.58 mg/kg, ip, respectively . Depending on the isobolographic analysis and calculating Y value, the type of pharmacological interaction between silymarin and ketamine at a ratio of 0.5:0.5 and 1:1 of their analgesic ED50 values of each drug , was antagonistic .In the writhing test the concomitant administration of silymarin and ketamine at 120mg/kg and 4mg/kg , ip, respectively reduce significantly the numbers of writhing in compare with silymarin120 mg/kg,ip and ketamine 4mg/kg, ip separately. The results suggest that the co-administration of silymarin and ketamine was ineffective to reduce the central pain while the concomitant administration of silymarin and ketamine was effective to reduce the visceral pain.

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Induction Drugs

Carter

2024

Pharmacology in Veterinary Anesthesia and Analgesia

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Ketamine Suppression of Chemically Induced Convulsions in the Two-Day-Old White Leghorn Cockerel

Cited by 18 publications

References 0 publications

Antagonism of N‐methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK‐801

Antagonism of N‐methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK‐801

Isobolographic analysis of analgesic interactions of silymarin with ketamine in mice

Induction Drugs

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