2022
DOI: 10.12681/jhvms.25780
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Ketamine or propofol anesthesia in dogs: how do they affect cytokines, antioxidants and neutrophil functions?

Abstract: The objective of the study is to investigate the effects of ketamine and propofol on cytokines, antioxidant defense system, and neutrophil functions in dogs. A total of 24 dogs were used. Dogs were divided into two groups as ketamine and propofol. The ketamine group received ketamine (5 mg/kg) intravenously while the propofol group received propofol (4 mg/kg) intravenously. Blood samples were collected before sedation and 30 minutes after induction. Serum antioxidant and cytokine levels were analyzed and neutr… Show more

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Cited by 2 publications
(3 citation statements)
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“…However, according to other studies, ketamine inhibits the oxidative burst of canine peripheral blood phagocytes in vitro ( 57 ), and exhibits neuroprotective effects by its anti-inflammatory, antioxidant, and anti-apoptotic effects in animal models of cognitive disfunction ( 58 ). These properties were partially confirmed in a study on the effects of ketamine and propofol on cytokines, oxidative status and neutrophil functions in dogs ( 46 ). In a study on Wistar rats ketamine showed a higher antioxidant potential compared to etomidate ( 59 ).…”
Section: Intravenous Anestheticsmentioning
confidence: 74%
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“…However, according to other studies, ketamine inhibits the oxidative burst of canine peripheral blood phagocytes in vitro ( 57 ), and exhibits neuroprotective effects by its anti-inflammatory, antioxidant, and anti-apoptotic effects in animal models of cognitive disfunction ( 58 ). These properties were partially confirmed in a study on the effects of ketamine and propofol on cytokines, oxidative status and neutrophil functions in dogs ( 46 ). In a study on Wistar rats ketamine showed a higher antioxidant potential compared to etomidate ( 59 ).…”
Section: Intravenous Anestheticsmentioning
confidence: 74%
“…In contrast, ketamine increases myocardial work and cardiac output, maintaining arterial pressure and heart rate ( 59 ). It has a mild effect on the respiratory system but can cause respiratory depression when used with other central nervous depressants ( 46 ). Anesthetic procedures in clinical trials include various agents for sedation, gentle induction of anesthesia, and analgesia.…”
Section: Discussionmentioning
confidence: 99%
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