Keratinization of the Duct of the Sebaceous Gland and Growth Cycle of the Hair Follicle in the Histogenesis of Acne in Human Skin1

Scott, Edward M.; MacCardle, Ross C.

doi:10.1038/jid.1956.115

Cited by 59 publications

(17 citation statements)

References 6 publications

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“…It is assumed that large lesions do not occur because of the anti-inflammatory effect of the steroid itself. Also, unlike acne vulgaris, follicular hyperkeratosis is not an early event, as was once believed [19].…”

Section: Drug-induced Acnementioning

confidence: 95%

Acneiform Dermatoses

Plewig

Jansen

1998

Dermatology

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Acneiform dermatoses are follicular eruptions. The initial lesion is inflammatory, usually a papule or pustule. Comedones are later secondary lesions, a sequel to encapsulation and healing of the primary abscess. The earliest histological event is spongiosis, followed by a break in the follicular epithelium. The spilled follicular contents provokes a nonspecific lymphocytic and neutrophilic infiltrate. Acneiform eruptions are almost always drug induced. Important clues are sudden onset within days, widespread involvement, unusual locations (forearm, buttocks), occurrence beyond acne age, monomorphous lesions, sometimes signs of systemic drug toxicity with fever and malaise, clearing of inflammatory lesions after the drug is stopped, sometimes leaving secondary comedones. Other cutaneous eruptions that may superficially resemble acne vulgaris but that are not thought to be related to it etiologically are due to infection (e.g. gramnegative folliculitis) or unknown causes (e.g. acne necrotica or acne aestivalis). oooooooooooooooooooo

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Section: Drug-induced Acnementioning

confidence: 95%

Acneiform Dermatoses

Plewig

Jansen

1998

Dermatology

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“…The earliest pathologic change is thickening or hyperkeratosis of the wall of the sebaceous duct, which then encroaches on the lumen and obstructs the outflow of sebum. 1 This change occurs at about the time of puberty, when production of sebum increases threefold. Apparently the …”

Section: Management Of Acne Vulgaris In General Practicementioning

confidence: 99%

Management of Acne Vulgaris in General Practice

Hj¹

1964

Postgraduate Medicine

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“…The role of the endocrines in sebaceous gland function is complex and still unclear. It has been convincingly dem onstrated th at testosterone induces sebaceous gland hyperplasia [3,5,6,11] and acneiform eruptions developing during corticotropin and corticosteroid therapy are gener ally thought to result from androgenic activity possessed either by these substances themselves or by some metabolic derivative [1,13], Van Scott and MacCardle [12] consider th at the induction of a resting (telogen) phase in the hair roots plays a major role, whilst the work of Lasher, Lorincz and Rothman [8,9] suggests th at an anterior pituitary (" sebotropic") factor is involved. It has been stated th at cortisone actually causes mild sebaceous gland atrophy [7] and Sullivan and Zeligman [15] m aintain th at the acnegenic effect of corticotropin is mediated solely by hyperkeratosis and blocking of the follicular orifice.…”

Section: Discussionmentioning

confidence: 99%