“…We conclude that this familiar disorder is a new autonomous clinical syndrome with the following main characteristics: its appearance during puberty or just afterwards, the monstrous nature of the sebaceous hyperplasia, the selective localization on the face, the neck and upper thorax, the lack of involvement of peri-orificial regions, the absence of acneiform lesions, the slow progressive nature of the disorder ultimately leading to an extremely unpleasant appearance, the ineffectiveness of conventional acne treatments, and histopathologically, a voluminous sebaceous hyperplasia with lack of inflammation. This rather unique disorder merits discussion regarding its relationship to certain other sebaceous gland disorders: (i) a common seborrhoea oleosa: our patients clearly presented with a considerable seborrhoea, but the most important sign was the sebaceous hyperplasia, entirely abnormal, even for an extreme seborrhoeai (2) an acne or an acneiform eruption: our patients exhibited no clinical or histological signs of the slightest inflammatory acneiform process; (3) a cutis punctata linearis colli (Even-Paz & Sagher, 1963): this disorder appears later in life, spares the face and corresponds to a cutaneous atrophy and not to a sebaceous hyperplasia; it is often observed in cases of solar atrophy or senile atrophy; (4) familial comedones: this particular and relatively rare disorder recently reported by Dantu et al (1978) represents an important differential diagnosis in relation to the cases we report here. The syndrome of familial comedomes appears at about 10 years of age and is characterized by comedones widely spread over the whole body with crateriform depressions containing a comedo which rapidly reforms if removed.…”