Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8).

Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-κB activation

“…Although HHV8 genome encodes for homologs of several chemokines and cytokines, none of them are expressed in cells latently infected with this virus (Schulz, 1998). In contrast, HHV8-encoded vFLIP is expressed in latently infected KS spindle cells and, therefore, may play a pivotal role in the upregulation of IL-8 production seen in association with HHV-8 infection (Schulz, 1998). .…”

“…Human herpesvirus 8 (HHV-8) or KS-associated herpesvirus (KSHV) is a g-2 herpesvirus that has been shown to be associated with all forms of KS (classical, iatrogenic, endemic and AIDS related) as well as a number of other neoplastic disorders, such as primary effusion lymphoma, multicentric Castleman's disease and angio-immunoblastic lymphadenopathy with dysproteinemia (Schulz, 1998;Dourmishev et al, 2003;Verma and Robertson, 2003). HHV-8 infection of endothelial cells induces IL-8 production, which plays a crucial role in the angiogenic phenotype developed by HHV-8-infected endothelial cells in culture and upon implantation into SCID mice (Lane et al, 2002).…”

Modulation of the NF-κB pathway by virally encoded Death Effector Domains-containing proteins

“…It has been suggested that KSHV/HHV8 causes KS by contributing to this cytokine dysregulation (Gallo, 1998;Karp et al, 1996). In fact, KSHV has been shown to encode for a homolog of IL-6 (vIL6) as well as a constitutively active G-protein coupled receptor with homology to IL-8 receptor (reviewed in Moore et al, 1996;Schulz, 1998). However, none of these genes are expressed in latently infected KS spindle cells, making it unlikely that they play a direct role in the abnormal cellular proliferation seen in KS (Moore et al, 1996;Schulz, 1998).…”

“…In fact, KSHV has been shown to encode for a homolog of IL-6 (vIL6) as well as a constitutively active G-protein coupled receptor with homology to IL-8 receptor (reviewed in Moore et al, 1996;Schulz, 1998). However, none of these genes are expressed in latently infected KS spindle cells, making it unlikely that they play a direct role in the abnormal cellular proliferation seen in KS (Moore et al, 1996;Schulz, 1998). On the contrary, ORF-K13 is expressed in the latently infected KS spindle cells and, as such, is an ideal candidate for the growth promoting role of KSHV 8/HHV8 (Schulz, 1998).…”

“…However, none of these genes are expressed in latently infected KS spindle cells, making it unlikely that they play a direct role in the abnormal cellular proliferation seen in KS (Moore et al, 1996;Schulz, 1998). On the contrary, ORF-K13 is expressed in the latently infected KS spindle cells and, as such, is an ideal candidate for the growth promoting role of KSHV 8/HHV8 (Schulz, 1998).…”