Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-κB activation

Sun, Qing; Matta, Hittu; Lu, Guifang; Chaudhary, Preet M.

doi:10.1038/sj.onc.1209298

Cited by 75 publications

(71 citation statements)

References 51 publications

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“…Some of these cytokines, such as interleukin (IL)-6 and IL-8, are known downstream targets of K13-induced NF-kB pathway Sun et al, 2006). As shown in Figure 3a, treatment of K13-ER TAM HUVEC cells with 4-OHT was accompanied by strong induction of IL-6 and IL-8 production in the cellular supernatant, thereby demonstrating that K13-induced spindle cell transformation of HUVEC cells is accompanied by production of proinflammatory cytokines.…”

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confidence: 93%

Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13

et al. 2006

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confidence: 93%

Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13

et al. 2006

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“…vFLIP has been shown to upregulate IL-8 in human umbilical vein endothelial cells (HUVECs) (Sun et al, 2006), and vFLIP is responsible for the spindling phenotype observed in KSHV-infected primary ECs, as well as the production of IL-6 (Grossmann et al, 2006). Here, we examine the effect of vFLIP expression on MVEC survival.…”

Section: Introductionmentioning

confidence: 99%

vFLIP from KSHV inhibits anoikis of primary endothelial cells

Efklidou

Bailey

Field

et al. 2008

Journal of Cell Science

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“…Additionally, CXCL8-CXCR2 signaling facilitates migration and proliferation of endothelial cells [92] , and the AKT pathway is important for GPCR-dependent angiogenesis [93] following CXCR1 and CXCR2 activation [49,81] . Also, the human herpesvirus-8, an etiological agent of the highly vascular Kaposi's sarcoma, induces expression of CXCL8 [94] , providing further evidence for chemokine involvement in tumorigenesis [95] .…”

Section: Chemokines and Angiogenesismentioning

confidence: 99%

Chemokines, chemokine receptors and the gastrointestinal system

Miyazaki¹,

Takabe²,

Yeudall³

2013

WJG

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Core tip: The chemokine network makes an attractive target for therapeutic intervention in many tumor types, including those of the gastrointestinal tract. However, we need to define more selective and specific targets, to minimize systemic side effects during treatment. INTRODUCTION Cancer development and progression in the gastrointestinal tractCancer is a disease in which normal cells acquire genetic and epigenetic abnormalities [1,2] , leading to disorientation of conventional processes for the maintenance of normal cell physiology. These aberrant genetic and epigenetic modifications to the normal cell induce abnormal cell motility, proliferation, and survival, eventually enabling these cells to invade into adjacent tissues and even to migrate to regional or distant organs where they may grow continuously as metastatic lesions [3] . For many cancer patients, metastasis is generally the major cause of disease-related death [4,5] . Therefore, it is indispensable to elucidate the basic molecular mechanisms of tumor development to identify effective therapeutic targets, which can possibly reduce the side-effects of treatment, and define useful molecular markers for early detection and prediction of disease course. Especially, the newly emerged concept of personalized medicine may require in-depth assessment of potential therapeutic molecular target(s) in each individual case through analysis of sig- REVIEW Chemokines, chemokine receptors and the gastrointestinal system AbstractThe biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors, which include epidermal growth factor receptor agonists and members of the transforming growth factor β family. Furthermore, the recent explosion of research in the field of chemokine function as mediators of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches. In this review, we will summarize recently reported findings in chemokine biology with a focus on the gastrointestinal tract.

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Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-κB activation

Cited by 75 publications

References 51 publications

Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13

Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13

vFLIP from KSHV inhibits anoikis of primary endothelial cells

Chemokines, chemokine receptors and the gastrointestinal system

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